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Enhancing Human Health through Plant-Based Dietary Bioactive Compounds

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 25 December 2024 | Viewed by 1309

Special Issue Editor


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Guest Editor
Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Palle-Juul-Jensens 165, DK-8250 Aarhus, Denmark
Interests: phytochemicals; health; welfare diseases; clinical research; in vivo studies; in vitro studies; plant-based bioactive compounds; nutraceutical
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Special Issue Information

Dear Colleagues,

In recent years, there has been an increasing focus on the importance of functional dietary bioactives in fostering health and warding off chronic diseases. These bioactive compounds, naturally occurring in a diverse array of plant-based foods and beverages, have garnered considerable attention for their capacity to improve overall well-being and promote healthier lifestyles. This Special Issue endeavors to delve deeply into the realm of functional dietary bioactives, illuminating their health advantages and scrutinizing the evolving consumption patterns associated with these compounds. All types of studies in the research field are welcome, from in vitro to in vivo experiments, as well as human intervention studies.

Dr. Per Bendix Jeppesen
Guest Editor

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Keywords

  • bioactive compounds
  • functional foods
  • new food trends
  • healthy foods
  • nutraceuticals

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Published Papers (1 paper)

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Research

20 pages, 3036 KiB  
Article
Beneficial Effects of a Freeze-Dried Kale Bar on Type 2 Diabetes Patients: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
by Per Bendix Jeppesen, Amanda Dorner, Yuan Yue, Nikolaj Poulsen, Sofie Korsgaard Andersen, Fie Breenfeldt Aalykke and Max Norman Tandrup Lambert
Nutrients 2024, 16(21), 3641; https://doi.org/10.3390/nu16213641 - 26 Oct 2024
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Abstract
Background/Objectives: Type 2 diabetes (T2D) is one of the most common global diseases, with an ever-growing need for prevention and treatment solutions. Kale (Brassica oleracea L. var. acephala) offers a good source of fiber, minerals, bioavailable calcium, unsaturated fatty acids, prebiotic [...] Read more.
Background/Objectives: Type 2 diabetes (T2D) is one of the most common global diseases, with an ever-growing need for prevention and treatment solutions. Kale (Brassica oleracea L. var. acephala) offers a good source of fiber, minerals, bioavailable calcium, unsaturated fatty acids, prebiotic carbohydrates, vitamins, health-promoting secondary plant metabolites, as well as higher amounts of proteins and essential amino acids compared to other vegetables. The objective of this study was to investigate whether daily intake of freeze-dried kale powder can provide health benefits for T2D patients vs. placebo. Methods: This study was designed as a 12-week, blinded, randomized, controlled trial. Thirty T2D patients were randomly assigned to either a placebo bar (control) or a kale bar (intervention). Participants in the intervention group were instructed to consume three bars/day, each containing 26.25 g of freeze-dried kale (corresponding to approx. 341 g fresh kale/day). At baseline and 12 weeks, all participants underwent an oral glucose tolerance test (OGTT), 24 h blood pressure measurements, DEXA scans, and fasted blood samples were taken. Results: A significant reduction in HbA1c, insulin resistance, body weight, and calorie intake was observed in the intervention group compared to control. Positive trends were detected in fasted blood glucose and LDL-cholesterol for those in the kale intervention group. No significant differences were found in total body fat mass and area under the curve glucose 240 min OGTT. Conclusions: Given the positive effects of high daily kale intake observed in this study, further research with a larger sample size is needed to better understand the health benefits of kale bars. This could potentially lead to new dietary recommendations for patients with T2D. Full article
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