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Nutritional Interventions for the Management of Inflammatory Bowel Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: closed (25 July 2024) | Viewed by 2082

Special Issue Editors


E-Mail Website1 Website2
Guest Editor
1. Department of Paediatrics, Christchurch Hospital, University of Otago Christchurch, Christchurch 4710, New Zealand
2. School of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia
Interests: inflammatory bowel disease; coeliac disease; improving Crohn’s outcomes; intestinal inflammatory biomarkers; nutritional aspects of gut diseases; host–pathogen interactions in the gut (and how these relate to chronic gut diseases)
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Perth Children’s Hospital, Perth, WA, Australia
Interests: inflammatory bowel disease; cystic fibrosis; malnutrition; gut microbiome; Crohns disease; paediatric gastroenterology; children diet

Special Issue Information

Dear Colleagues,

The group of conditions known as inflammatory bowel disease (IBD) encompass Crohn’s disease (CD), ulcerative colitis (UC) and IBD unclassified (IBDU). Dietary factors appear to contribute to the pathogenesis of these conditions and they are associated with various adverse nutritional consequences. Furthermore, nutritional interventions are increasingly recognised as having roles in the management of these conditions. For example, exclusive enteral nutrition (EEN) has been considered a therapy to induce remission for many years; it is now recommended in several guidelines as the preferred first-line therapy for children after CD diagnosis and is used in many centres for children and adults. Other nutritional interventions have been developed and evaluated in recent years. These include the CD Exclusion Diet (CDED), Specific Carbohydrate Diet (SCD), Mediterranean Diet (MED) and numerous other nutritional approaches.

Whilst there is increasing interest from individuals with IBD, the use of these interventions appears to vary substantially between centres and countries. In addition, the consideration of which intervention and the relative merits of one over another are unclear.

The impact of these nutritional interventions on the underlying inflammation and the intestinal microbiome have not been fully elucidated, along with the mechanisms of action. While these interventions clearly have important roles in the management of IBD, many gaps remain in the current understanding.

This research topic welcomes submissions of original research articles and review articles that relate to the role and impact of nutritional interventions in individuals with IBD. 

The topics for this call for papers include, but are not restricted to:

•    The short- and long-term outcomes of nutritional interventions in individuals with active IBD;
•    The role of nutritional interventions in the maintenance of remission in individuals with IBD;
•    Factors that might predict or be valuable in enhancing the outcome of these interventions;
•    The mechanisms by which these nutritional interventions have their described outcomes;
•    Comparisons between different interventions and across different settings (such as geographical, cultural or other);
•    Interactions between these interventions and other medical or surgical interventions in individuals with IBD;
•    The attitudes and approaches to these interventions by healthcare professionals and individuals with IBD.

Prof. Dr. Andrew S. Day
Dr. Zubin Grover
Guest Editors

Manuscript Submission Information

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Keywords

  • inflammatory bowel disease (IBD)
  • nutritional interventions
  • CROHN’S disease (CD)
  • ulcerative colitis (UC)
  • IBD unclassified (IBDU)
  • dietary factors
  • exclusive enteral nutrition (EEN)
  • intestinal microbiome

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Published Papers (1 paper)

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Research

12 pages, 803 KiB  
Article
Preoperative Crohn’s Disease Exclusion Diet and Exclusive Enteral Nutrition in Adults with Crohn’s Disease: A Feasibility Randomised Controlled Trial
by Catherine L. Wall, Rachael Bensley, Tamara Glyn, Melissa Haines, David Rowbotham, Ian Bissett, Timothy Eglinton and Richard B. Gearry
Nutrients 2024, 16(13), 2105; https://doi.org/10.3390/nu16132105 - 2 Jul 2024
Cited by 1 | Viewed by 1738
Abstract
Preoperative exclusive enteral nutrition (EEN) improves nutritional status, reduces intestinal inflammation, and likely improves surgical outcomes. Crohn’s disease exclusion diet with partial enteral nutrition (CDED) also reduces intestinal inflammation but its safety preoperatively is unknown. This single-blinded, multicentre, randomised controlled trial of three [...] Read more.
Preoperative exclusive enteral nutrition (EEN) improves nutritional status, reduces intestinal inflammation, and likely improves surgical outcomes. Crohn’s disease exclusion diet with partial enteral nutrition (CDED) also reduces intestinal inflammation but its safety preoperatively is unknown. This single-blinded, multicentre, randomised controlled trial of three preoperative nutritional therapies aimed to assess the feasibility of recruiting and retaining patients and collecting primary and secondary effectiveness outcomes. Adults undergoing elective Crohn’s disease surgery with a body mass index (BMI) > 18.5 kg/m2 and without significant weight loss were eligible to participate. Patients were randomly assigned to six weeks of preoperative EEN, CDED, or standard care. Feasibility, nutritional, radiological, and surgical outcomes were recorded. Over 18 months, 48 patients were screened, 17 (35%) were randomised, and 13/17 (76%) patients were retained in the intervention phase. It was feasible to collect primary and secondary effectiveness data; at day 30, three patients had Clavien Dindo Grade 2 complications, and 10 had no complications. Nutritional therapy adherence of patients retained in the study was high. Recruitment and retention of patients who need elective Crohn’s disease surgery for preoperative nutritional therapy is possible, although a shorter duration may improve EEN completion. The impact on surgical outcomes should be assessed in a larger study. Full article
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