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The Role of Bioactive Compounds in Neuroprotection and Neurodegenerative Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1566

Special Issue Editors


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Guest Editor
Department of Morphological and Sociosanitary Sciences, University of Cordoba, Cordoba, Spain
Interests: preclinical studies; innervation; regeneration; histology; muscle damage

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Guest Editor
Neurovascular Lab, Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, 41013 Seville, Spain
Interests: neuroprotectancts; preclinical studies; drug discovery; stroke; neurovascular; nutraceuticals
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Special Issue Information

Dear Colleagues,

Bioactive compounds have been described as counteracting many of the pathological processes associated with neurodegeneration, given their antioxidant, anti-inflammatory, and neurotransmitter-modulating effects, among others. Therefore, it is not surprising that bioactive compounds have been suggested to play a role in neuroprotection and the management of neurodegenerative diseases.

These substances are often obtained from natural sources such as plants, fruits, or vegetables, and incorporating bioactive compounds into diets or as supplements offers a promising avenue for supporting brain health and function. However, more research is needed to fully understand their mechanisms of action and develop effective preventive and therapeutic strategies for neurodegeneration.

This Special Issue aims to gather recent knowledge on the effects of bioactive compounds in neuroprotection and their role in modulating neurodegenerative diseases. It is an exciting opportunity to highlight recent advances in this critical area of research. Original research articles (preclinical and human studies) and comprehensive reviews are welcome.

Dr. Irene Cantarero-Carmona
Dr. Carmen Del Río Mercado
Guest Editors

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Keywords

  • neurodegenerative diseases
  • bioactive compounds
  • neuroprotection
  • food supplement

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Published Papers (1 paper)

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Research

25 pages, 5956 KiB  
Article
Anti-Neuroinflammatory Potential of Areca Nut Extract and Its Bioactive Compounds in Anthracene-Induced BV-2 Microglial Cell Activation
by Sakawrat Janpaijit, Monruedee Sukprasansap, Tewin Tencomnao and Anchalee Prasansuklab
Nutrients 2024, 16(17), 2882; https://doi.org/10.3390/nu16172882 - 28 Aug 2024
Viewed by 1261
Abstract
Particulate matter (PM2.5) containing polycyclic aromatic hydrocarbons (PAHs) is of considerable environmental importance worldwide due to its adverse effects on human health, which are associated with neurodegenerative diseases (NDDs). Areca catechu L. (AC) fruit is known to possess various pharmacological properties; [...] Read more.
Particulate matter (PM2.5) containing polycyclic aromatic hydrocarbons (PAHs) is of considerable environmental importance worldwide due to its adverse effects on human health, which are associated with neurodegenerative diseases (NDDs). Areca catechu L. (AC) fruit is known to possess various pharmacological properties; however, the anti-neuroinflammatory roles of AC on the suppression of PAH-induced neuroinflammation are still limited. Thus, we focused on the effects and related signaling cascades of AC and its active compounds against anthracene-induced toxicity and inflammation in mouse microglial BV-2 cells. Phytochemicals in the ethanolic extract of AC (ACEE) were identified using LC-MS, and molecular docking was conducted to screen the interaction between compounds and target proteins. Significant bioactive compounds in ACEE such as arecoline, (−)-epicatechin, and syringic acid were evinced through the LC-MS spectrum. The docking study revealed that (−)-epicatechin showed the highest binding affinities against NF-κB. For cell-based approaches, anthracene induced intracellular ROS, mRNA levels of TNF-α, IL-1β, and IL-6, and the release of TNF-α through enhancing JNK, p38, and NF-κB signaling pathways. However, the co-treatment of cells with ACEE or (−)-epicatechin could reverse those anthracene-induced changes. The overall study suggested that ACEE-derived bioactive compounds such as (−)-epicatechin may be developed as a potential anti-neuroinflammatory agent by preventing inflammation-mediated NDDs. Full article
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