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Nutrients
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Food Allergy and Clinical Immunology
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Food Allergy and Clinical Immunology

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: closed (25 March 2022) | Viewed by 9230

Special Issue Editors

Prof. Dr. Maria Leite-de-Moraes

E-Mail Website
Guest Editor
Laboratory of Immunoregulation and Immunopathology, INEM (Institut Necker-Enfants Malades), CNRS UMR8253 and Inserm UMR1151, Paris, France
Interests: inflammation; immunoregulation; allergy; mucosal-associated invariant T cells (MAITs); invariant natural killer T cells (iNKTs)
Special Issues, Collections and Topics in MDPI journals
Dr. Karine Adel-Patient

E-Mail Website
Guest Editor
Service de Pharmacologie et d’Immunoanalyse, Département Médicaments et Technologies pour la Santé (DMTS), CEA, INRAE, Université Paris-Saclay, SPI, 91191, Gif-sur-Yvette, France
Interests: allergens; immune tolerance; allergic sensitization; immune regulation; flow cytometry; immunomodulation

Special Issue Information

Dear Colleagues,

Food allergy is a common immune disorder that has increased in prevalence over the last two to three decades. In Western countries, up to 10% of children and 4% of adults are affected. The majority of patients are allergic to milk, egg, peanuts, tree nuts, fish, or shellfish. Food allergic reactions are responsible for a variety of symptoms and disorders involving the skin and gastrointestinal and respiratory tracts. IgE-mediated and non-IgE-mediated (cellular) mechanisms, as well as eosinophils, mast cells, ILCs (innate lymphoid cells) and Th2 cells, have emerged as key factors associated with food allergic disorders such as eosinophilic esophagitis, food-protein-induced enterocolitis syndrome (FPIES), or food-protein-induced proctocolitis. The field of therapeutics is advancing rapidly. Despite these major advances, a full understanding of the immune mechanisms involved in distinct phenotypes and endotypes of food allergy is still required to propose a “personalized medicine” approach for the treatment of this pathology.

This Special Issue invites comprehensive reviews, immune mechanism analyses, and studies employing cell and animal models that further elucidate the relationship between food allergy, inflammation, microbiota, and immune reactions in children and adults.

Prof. Dr. Maria Leite-de-Moraes
Dr. Karine Adel-Patient
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food allergy
  • food hypersensitivity
  • oral tolerance
  • immunoregulation
  • gastrointestinal food hypersensitivity
  • dysbiosis
  • microbiome
  • food allergens
  • immunotherapy
  • animal models of food allergy

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Published Papers (2 papers)

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13 pages, 2795 KiB  
Article
Route of Sensitization to Peanut Influences Immune Cell Recruitment at Various Mucosal Sites in Mouse: An Integrative Analysis
by Mélanie Briard, Marine Guinot, Marta Grauso, Blanche Guillon, Stéphane Hazebrouck, Hervé Bernard, Grégory Bouchaud, Marie-Laure Michel and Karine Adel-Patient
Nutrients 2022, 14(4), 790; https://doi.org/10.3390/nu14040790 - 14 Feb 2022
Cited by 5 | Viewed by 2624
Abstract
Symptom occurrence at the first ingestion suggests that food allergy may result from earlier sensitization via non-oral routes. We aimed to characterize the cellular populations recruited at various mucosal and immune sites after experimental sensitization though different routes. BALB/cJ mice were exposed to [...] Read more.
Symptom occurrence at the first ingestion suggests that food allergy may result from earlier sensitization via non-oral routes. We aimed to characterize the cellular populations recruited at various mucosal and immune sites after experimental sensitization though different routes. BALB/cJ mice were exposed to a major allergenic food (peanut) mixed with cholera toxin via the intra-gastric (i.g.), respiratory, cutaneous, or intra-peritoneal (i.p.) route. We assessed sensitization and elicitation of the allergic reaction and frequencies of T cells, innate lymphoid cells (ILC), and inflammatory and dendritic cells (DC) in broncho-alveolar lavages (BAL), lungs, skin, intestine, and various lymph nodes. All cellular data were analyzed through non-supervised and supervised uni/multivariate analysis. All exposure routes, except cutaneous, induced sensitization, but intestinal allergy was induced only in i.g.- and i.p.-exposed mice. Multivariate analysis of all cellular constituents did not discriminate i.g. from control mice. Conversely, respiratory-sensitized mice constituted a distinct cluster, characterized by high local inflammation and immune cells recruitment. Those mice also evidenced changes in ILC frequencies at distant site (intestine). Despite absence of sensitization, cutaneous-exposed mice evidenced comparable changes, albeit less intense. Our study highlights that the initial route of sensitization to a food allergen influences the nature of the immune responses at various mucosal sites. Interconnections of mucosal immune systems may participate in the complexity of clinical manifestations as well as in the atopic march. Full article
(This article belongs to the Special Issue Food Allergy and Clinical Immunology)
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Review

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12 pages, 992 KiB  
Review
Intestinal Barrier Permeability in Allergic Diseases
by Monika Niewiem and Urszula Grzybowska-Chlebowczyk
Nutrients 2022, 14(9), 1893; https://doi.org/10.3390/nu14091893 - 30 Apr 2022
Cited by 45 | Viewed by 6053
Abstract
The role of intestinal permeability (IP) markers among children and adults with food allergies is not fully understood, and the identification of biological indicators/markers that predict growth retardation in children with allergic diseases and atopy has not been well explained. Studies have shown [...] Read more.
The role of intestinal permeability (IP) markers among children and adults with food allergies is not fully understood, and the identification of biological indicators/markers that predict growth retardation in children with allergic diseases and atopy has not been well explained. Studies have shown that patients with atopic diseases respond abnormally to food allergens. Accordingly, differences in the types of immune complexes formed in response to antigen challenges are significant, which seems to underlie the systemic signs of the food allergy. Increased intestinal permeability over the course of a food allergy allows allergens to penetrate through the intestinal barrier and stimulate the submucosal immune system. Additionally, the release of cytokines and inflammatory mediators enhances the degradation of the epithelial barrier and leads to an improper cycle, resulting in increased intestinal permeability. Several studies have also demonstrated increased permeability of the epithelial cells in those afflicted with atopic eczema and bronchial asthma. Ongoing research is aimed at finding various indicators to assess IP in patients with atopic diseases. Full article
(This article belongs to the Special Issue Food Allergy and Clinical Immunology)
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