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The Implications of Polyphenols on Aging

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (18 January 2024) | Viewed by 7746

Special Issue Editor


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Guest Editor
Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, Via S. Camillo de Lellis, 01100 Viterbo, Italy
Interests: organic chemistry; natural products chemistry; pharmaceutical chemistry; green chemistry; natural and synthetic biologically active compounds; dietary bioactive compounds; antioxidants

Special Issue Information

Dear Colleagues,

The aging process is characterized by a progressive decline in function and structure throughout the organism, leading to death. Oxidative stress, a condition that occurs when the production of reactive oxygen species overcomes cellular antioxidant defenses, is a common hallmark of aging. Polyphenols are potentially health-promoting compounds in plant foods whose strong antioxidant properties allow them to remove excess reactive oxygen species in the body, prevent cell aging, and delay aging and chronic diseases. Interest in the relationship between diet and aging has grown in recent decades, and some antioxidants have now been identified to be capable of extending the lifespan in various models of aging. This Special Issue aims to bring together the latest research on these topics. Research on the antiaging capabilities of polyphenols and bioactive ingredients and their molecular aspects will be considered. Therefore, it is my great pleasure to invite scientists to submit manuscripts describing original research or  review on the topic to this Special Issue.

Dr. Roberta Bernini
Guest Editor

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Keywords

  • anti-aging
  • aging
  • polyphenols
  • functional food
  • bioactive ingredients
  • age-related disorders
  • dietary antioxidants

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Published Papers (1 paper)

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Review

55 pages, 3200 KiB  
Review
Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota
by Laura Micheli, Laura Bertini, Agnese Bonato, Noemi Villanova, Carla Caruso, Maurizia Caruso, Roberta Bernini and Felice Tirone
Nutrients 2023, 15(7), 1767; https://doi.org/10.3390/nu15071767 - 4 Apr 2023
Cited by 25 | Viewed by 7148
Abstract
Aging is a multi-faceted process caused by the accumulation of cellular damage over time, associated with a gradual reduction of physiological activities in cells and organs. This degeneration results in a reduced ability to adapt to homeostasis perturbations and an increased incidence of [...] Read more.
Aging is a multi-faceted process caused by the accumulation of cellular damage over time, associated with a gradual reduction of physiological activities in cells and organs. This degeneration results in a reduced ability to adapt to homeostasis perturbations and an increased incidence of illnesses such as cognitive decline, neurodegenerative and cardiovascular diseases, cancer, diabetes, and skeletal muscle pathologies. Key features of aging include a chronic low-grade inflammation state and a decrease of the autophagic process. The Mediterranean diet has been associated with longevity and ability to counteract the onset of age-related disorders. Extra virgin olive oil, a fundamental component of this diet, contains bioactive polyphenolic compounds as hydroxytyrosol (HTyr) and oleuropein (OLE), known for their antioxidant, anti-inflammatory, and neuroprotective properties. This review is focused on brain, skeletal muscle, and gut microbiota, as these systems are known to interact at several levels. After the description of the chemistry and pharmacokinetics of HTyr and OLE, we summarize studies reporting their effects in in vivo and in vitro models of neurodegenerative diseases of the central/peripheral nervous system, adult neurogenesis and depression, senescence and lifespan, and age-related skeletal muscle disorders, as well as their impact on the composition of the gut microbiota. Full article
(This article belongs to the Special Issue The Implications of Polyphenols on Aging)
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