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Nutrients
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Diet and Microbiota-Gut-Brain Axis in Neurodegenerative Diseases
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Diet and Microbiota-Gut-Brain Axis in Neurodegenerative Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 23575

Special Issue Editors

Dr. Katarzyna Socała

E-Mail Website
Guest Editor
Department of Animal Physiology and Pharmacology, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, Poland
Interests: epilepsy; behavioral neuroscience; neuropharmacology; gut microbiota and CNS disorders; probiotics
Prof. Dr. Piotr Wlaź

E-Mail Website
Guest Editor
Department of Animal Physiology and Pharmacology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, Poland
Interests: neurobiology; epilepsy; depression; anxiety; behavioral neuroscience; gut microbiota and CNS disorders
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Special Issue Information

Dear Colleagues,

Neurodegenerative diseases are becoming an increasing social and economic burden for both patients and communities. Finding the causes and novel treatment options for these diseases is of great importance. Recently, considerable attention has been paid to the role of the gut–microbiota axis in the pathophysiology and treatment of neurodegenerative disease. The gut–microbiota communicate with the brain through neuroanatomical pathways, neuroimmunological, neuroendocrine, or metabolic pathways, and evidence shows that dysregulation of the gut–microbiota axis may contribute to the development of neurodegenerative diseases. Consequently, modification of the gut microbiota through diet and nutrition may open up new avenues for the management of neurodegenerative diseases.

This Special Issue will collect original research articles and review papers (systematic reviews and meta-analyses) on the relationship between the gut–microbiota–brain axis and neurodegenerative diseases with a special emphasis on investigations describing the effects of diet and nutrients on symptoms, risk, and pathophysiological aspects of neurodegenerative diseases.

Dr. Katarzyna Socała
Prof. Dr. Piotr Wlaź
Guest Editors

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Keywords

  • gut–microbiota–brain axis
  • dysbiosis
  • neurodegeneration
  • neurodegenerative diseases
  • diet/nutrition
  • prebiotics/probiotics/symbiotics

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Published Papers (3 papers)

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Review

17 pages, 1269 KiB  
Review
The Role of Diet and Gut Microbiota in Alzheimer’s Disease
by D. M. Sithara Dissanayaka, Vijay Jayasena, Stephanie R. Rainey-Smith, Ralph N. Martins and W. M. A. D. Binosha Fernando
Nutrients 2024, 16(3), 412; https://doi.org/10.3390/nu16030412 - 31 Jan 2024
Cited by 17 | Viewed by 9692
Abstract
Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (Aβ) plaques and hyperphosphorylated tau tangles. Currently, Alzheimer’s disease (AD) impacts 50 million individuals, with projections anticipating an increase to 152 million by the year 2050. Despite [...] Read more.
Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (Aβ) plaques and hyperphosphorylated tau tangles. Currently, Alzheimer’s disease (AD) impacts 50 million individuals, with projections anticipating an increase to 152 million by the year 2050. Despite the increasing global prevalence of AD, its underlying pathology remains poorly understood, posing challenges for early diagnosis and treatment. Recent research suggests a link between gut dysbiosis and the aggregation of Aβ, the development of tau proteins, and the occurrence of neuroinflammation and oxidative stress are associated with AD. However, investigations into the gut–brain axis (GBA) in the context of AD progression and pathology have yielded inconsistent findings. This review aims to enhance our understanding of microbial diversity at the species level and the role of these species in AD pathology. Additionally, this review addresses the influence of confounding elements, including diet, probiotics, and prebiotics, on AD throughout different stages (preclinical, mild cognitive impairment (MCI), and AD) of its progression. Full article
(This article belongs to the Special Issue Diet and Microbiota-Gut-Brain Axis in Neurodegenerative Diseases)
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14 pages, 918 KiB  
Review
The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases
by Witold Czarnik, Piotr Fularski, Agata Gajewska, Paulina Jakubowska, Zofia Uszok, Ewelina Młynarska, Jacek Rysz and Beata Franczyk
Nutrients 2024, 16(2), 308; https://doi.org/10.3390/nu16020308 - 19 Jan 2024
Cited by 7 | Viewed by 3685
Abstract
Many researchers propose manipulating microbiota to prevent and treat related diseases. The brain–gut axis is an object that remains the target of modern research, and it is not without reason that many researchers enrich it with microbiota and diet in its name. Numerous [...] Read more.
Many researchers propose manipulating microbiota to prevent and treat related diseases. The brain–gut axis is an object that remains the target of modern research, and it is not without reason that many researchers enrich it with microbiota and diet in its name. Numerous connections and mutual correlations have become the basis for seeking answers to many questions related to pathology as well as human physiology. Disorders of this homeostasis as well as dysbiosis itself accompany neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Heavily dependent on external factors, modulation of the gut microbiome represents an opportunity to advance the treatment of neurodegenerative diseases. Probiotic interventions, synbiotic interventions, or fecal transplantation can undoubtedly support the biotherapeutic process. A special role is played by diet, which provides metabolites that directly affect the body and the microbiota. A holistic view of the human organism is therefore essential. Full article
(This article belongs to the Special Issue Diet and Microbiota-Gut-Brain Axis in Neurodegenerative Diseases)
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22 pages, 6103 KiB  
Review
Understanding the Gut–Brain Axis and Its Therapeutic Implications for Neurodegenerative Disorders
by Yadong Zheng, Laura Bonfili, Tao Wei and Anna Maria Eleuteri
Nutrients 2023, 15(21), 4631; https://doi.org/10.3390/nu15214631 - 31 Oct 2023
Cited by 23 | Viewed by 9492
Abstract
The gut–brain axis (GBA) is a complex bidirectional communication network connecting the gut and brain. It involves neural, immune, and endocrine communication pathways between the gastrointestinal (GI) tract and the central nervous system (CNS). Perturbations of the GBA have been reported in many [...] Read more.
The gut–brain axis (GBA) is a complex bidirectional communication network connecting the gut and brain. It involves neural, immune, and endocrine communication pathways between the gastrointestinal (GI) tract and the central nervous system (CNS). Perturbations of the GBA have been reported in many neurodegenerative disorders (NDDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), among others, suggesting a possible role in disease pathogenesis. The gut microbiota is a pivotal component of the GBA, and alterations in its composition, known as gut dysbiosis, have been associated with GBA dysfunction and neurodegeneration. The gut microbiota might influence the homeostasis of the CNS by modulating the immune system and, more directly, regulating the production of molecules and metabolites that influence the nervous and endocrine systems, making it a potential therapeutic target. Preclinical trials manipulating microbial composition through dietary intervention, probiotic and prebiotic supplementation, and fecal microbial transplantation (FMT) have provided promising outcomes. However, its clear mechanism is not well understood, and the results are not always consistent. Here, we provide an overview of the major components and communication pathways of the GBA, as well as therapeutic approaches targeting the GBA to ameliorate NDDs. Full article
(This article belongs to the Special Issue Diet and Microbiota-Gut-Brain Axis in Neurodegenerative Diseases)
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