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The Association between Dietary Acrylamide Exposure and Cancer Risk
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The Association between Dietary Acrylamide Exposure and Cancer Risk

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: closed (1 July 2021) | Viewed by 20473

Special Issue Editors

Prof. Dr. Junko Ishihara

E-Mail Website
Guest Editor
Department of Food and Life Science, School of Life and Environmental Science, Azabu University, Kanagawa 252-5201, Japan
Interests: nutrition epidemiology; dietary assessment; prevention of non-communicable disease; acrylamide exposure
Prof. Dr. Tomotaka Sobue

E-Mail Website
Guest Editor
Department Social and Environmental Medicine, Division Environmental Medicine and Population Sciences, Graduate School of Medicine, Osaka University, 2-5 Yamada Oka, Suita, Osaka 5650871, Japan
Interests: cancer control; dietary factors; risk assessment research; environmental effects

Special Issue Information

Dear Colleagues, 

Acrylamide was classified as a probable human carcinogen (group 2A) by The International Agency for Research on Cancer in 1994. Besides occupational exposures and smoking, diet is the main source of exposure in humans.

The association between dietary exposure assessed by food frequency questionnaires and various cancer risks has been investigated in several cohort studies. Although a few studies have investigated the association using biomarkers in blood or urine for acrylamide exposure, the cancer risk caused by acrylamide exposure remains inconclusive.

This Special Issue will bring together recent research on the topic of dietary acrylamide in cancer risk using nutrition assessments. Submissions of original research, narrative and systematic reviews, and meta-analyses will be included. Studies in which aspects of both dietary measurements (i.e., diet records or recalls, duplicated methods, or food frequency questionnaires) and biomarkers as exposure assessment methods will be considered. Methodological studies of dietary and biomarker measurements in terms of their application in epidemiological studies are especially welcome.

Prof. Junko Ishihara
Prof. Tomotaka Sobue
Guest Editors

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Keywords

  • Acrylamide
  • Glycidamide
  • Cancer risk
  • Dietary Exposure Assessment
  • Acrylamide-hemoglobin Adduct
  • Biomarker

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Published Papers (6 papers)

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Research

10 pages, 643 KiB  
Article
Dietary Acrylamide Intake and the Risks of Renal Cell, Prostate, and Bladder Cancers: A Japan Public Health Center-Based Prospective Study
by Sayaka Ikeda, Tomotaka Sobue, Tetsuhisa Kitamura, Junko Ishihara, Ayaka Kotemori, Ling Zha, Rong Liu, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane and on behalf of the JPHC Study Group
Nutrients 2021, 13(3), 780; https://doi.org/10.3390/nu13030780 - 27 Feb 2021
Cited by 10 | Viewed by 2795
Abstract
Acrylamide can be carcinogenic to humans. However, the association between the acrylamide and the risks of renal cell, prostate, and bladder cancers in Asians has not been assessed. We aimed to investigate this association in the Japan Public Health Center-based Prospective Study data [...] Read more.
Acrylamide can be carcinogenic to humans. However, the association between the acrylamide and the risks of renal cell, prostate, and bladder cancers in Asians has not been assessed. We aimed to investigate this association in the Japan Public Health Center-based Prospective Study data in 88,818 Japanese people (41,534 men and 47,284 women) who completed a food frequency questionnaire in the five-year follow-up survey in 1995 and 1998. A validated food frequency questionnaire was used to assess the dietary acrylamide intake. Cox proportional hazard regression models were used to estimate hazard ratios and 95% confidence intervals (CIs). During a mean follow-up of 15.5 years (15.2 years of prostate cancer), 208 renal cell cancers, 1195 prostate cancers, and 392 bladder cancers were diagnosed. Compared to the lowest quintile of acrylamide intake, the multivariate hazard ratios for the highest quintile were 0.71 (95% CI: 0.38–1.34, p for trend = 0.294), 0.96 (95% CI: 0.75–1.22, p for trend = 0.726), and 0.87 (95% CI: 0.59–1.29, p for trend = 0.491) for renal cell, prostate, and bladder cancers, respectively, in the multivariate-adjusted model. No significant associations were observed in the stratified analyses based on smoking. Dietary acrylamide intake was not associated with the risk of renal cell, prostate, and bladder cancers. Full article
(This article belongs to the Special Issue The Association between Dietary Acrylamide Exposure and Cancer Risk)
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13 pages, 442 KiB  
Article
Dietary Acrylamide Intake and the Risk of Hematological Malignancies: The Japan Public Health Center-Based Prospective Study
by Ling Zha, Rong Liu, Tomotaka Sobue, Tetsuhisa Kitamura, Junko Ishihara, Ayaka Kotemori, Sayaka Ikeda, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane and for the JPHC Study Group
Nutrients 2021, 13(2), 590; https://doi.org/10.3390/nu13020590 - 11 Feb 2021
Cited by 13 | Viewed by 2762
Abstract
Acrylamide, which is present in many daily foods, is a probable human carcinogen. In 2002, it was identified in several common foods. Subsequently, western epidemiologists began to explore the relationship between dietary acrylamide exposure and cancer risk; however, limited suggestive associations were found. [...] Read more.
Acrylamide, which is present in many daily foods, is a probable human carcinogen. In 2002, it was identified in several common foods. Subsequently, western epidemiologists began to explore the relationship between dietary acrylamide exposure and cancer risk; however, limited suggestive associations were found. This prospective study aimed to examine the association between dietary acrylamide intake and the risk of hematological malignancies, including malignant lymphoma (ML), multiple myeloma (MM), and leukemia. We enrolled 85,303 participants in the Japan Public Health Center-based Prospective study on diet and cancer as from 1995. A food frequency questionnaire that included data on acrylamide in all Japanese foods was used to assess dietary acrylamide intake. We applied multivariable adjusted Cox proportional hazards models to reckon hazard ratios (HRs) for acrylamide intake for both categorical variables (tertiles) and continuous variables. After 16.0 median years of follow-up, 326 confirmed cases of ML, 126 cases of MM, and 224 cases of leukemia were available for final multivariable-adjusted analysis. HRs were 0.87 (95% confidence interval [CI]: 0.64–1.18) for ML, 0.64 (95% CI: 0.38–1.05) for MM, and 1.01 (95% CI: 0.71–1.45) for leukemia. Our results implied that acrylamide may not be related to the risk of hematological malignancies. Full article
(This article belongs to the Special Issue The Association between Dietary Acrylamide Exposure and Cancer Risk)
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12 pages, 251 KiB  
Article
Acrylamide–Hemoglobin Adduct Levels in a Japanese Population and Comparison with Acrylamide Exposure Assessed by the Duplicated Method or a Food Frequency Questionnaire
by Junpei Yamamoto, Junko Ishihara, Yasuto Matsui, Tomonari Matsuda, Ayaka Kotemori, Yazhi Zheng, Daisuke Nakajima, Miho Terui, Akiko Shinohara, Shuichi Adachi, Junko Kawahara and Tomotaka Sobue
Nutrients 2020, 12(12), 3863; https://doi.org/10.3390/nu12123863 - 17 Dec 2020
Cited by 5 | Viewed by 2905
Abstract
The levels of hemoglobin adducts of acrylamide (AA–Hb), a biomarker of acrylamide exposure, have not been reported for Japanese subjects. Herein, we determined the AA–Hb levels in a Japanese population and compared them with the estimated dietary intake from the duplicate diet method [...] Read more.
The levels of hemoglobin adducts of acrylamide (AA–Hb), a biomarker of acrylamide exposure, have not been reported for Japanese subjects. Herein, we determined the AA–Hb levels in a Japanese population and compared them with the estimated dietary intake from the duplicate diet method (DM) and a food frequency questionnaire (FFQ). One-day DM samples, FFQ, and blood samples were collected from 89 participants and analyzed for acrylamide. AA–Hb was analyzed using liquid chromatography tandem mass spectrometry and the N-alkyl Edman method. Participants were divided into tertiles of estimated acrylamide intake and geometric means (GMs) of AA–Hb adjusted for sex and smoking status. A stratified analysis according to smoking status was also performed. The average AA–Hb levels for all participants, never, past, and current smokers were 46, 38, 65, and 86 pmol/g Hb, respectively. GMs of AA–Hb levels in all participants were significantly associated with tertiles of estimated acrylamide intake from DM (p for trend = 0.02) and FFQ (p for trend = 0.04), although no association with smokers was observed. AA–Hb levels reflected smoking status, which were similar to values reported in Western populations, and they were associated with estimated dietary intake of acrylamide when adjusted for sex and smoking status. Full article
(This article belongs to the Special Issue The Association between Dietary Acrylamide Exposure and Cancer Risk)
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14 pages, 1114 KiB  
Article
Dietary Acrylamide Intake and the Risk of Pancreatic Cancer: The Japan Public Health Center-Based Prospective Study
by Kumiko Kito, Junko Ishihara, Ayaka Kotemori, Ling Zha, Rong Liu, Norie Sawada, Motoki Iwasaki, Tomotaka Sobue and Shoichiro Tsugane
Nutrients 2020, 12(11), 3584; https://doi.org/10.3390/nu12113584 - 22 Nov 2020
Cited by 18 | Viewed by 3979
Abstract
Acrylamide is a probable carcinogen in humans. Few studies have assessed dietary acrylamide intake and the risk of pancreatic cancer; however, these studies are based on Western populations. Our purpose was to investigate the association of dietary acrylamide intake with the risk of [...] Read more.
Acrylamide is a probable carcinogen in humans. Few studies have assessed dietary acrylamide intake and the risk of pancreatic cancer; however, these studies are based on Western populations. Our purpose was to investigate the association of dietary acrylamide intake with the risk of pancreatic cancer utilizing data from the Japan Public Health Center-based Prospective Study. We evaluated the data of 89,729 participants aged 45–74 years, who replied to a questionnaire on past medical history and lifestyle habits from 1995–1998. Dietary acrylamide intake was estimated utilizing a validated food frequency questionnaire. We calculated the hazard ratios and 95% confidence intervals by using Cox proportional-hazards regression models. The average follow-up was 15.2 years, and 576 cases of pancreatic cancer were diagnosed. In the multivariate-adjusted model, an association between dietary acrylamide intake and pancreatic cancer risk was not demonstrated (hazard ratio for the highest vs. lowest quartile = 0.83, 95% confidence interval: 0.65–1.05, p for trend = 0.07). Furthermore, in the analyses stratified by sex, smoking status, coffee consumption, green tea consumption, alcohol consumption, and body mass index, no significant association was detected. Dietary acrylamide intake was not associated with the pancreatic cancer risk in Japanese individuals. Full article
(This article belongs to the Special Issue The Association between Dietary Acrylamide Exposure and Cancer Risk)
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12 pages, 384 KiB  
Article
Dietary Acrylamide Intake and the Risk of Liver Cancer: The Japan Public Health Center-Based Prospective Study
by Ling Zha, Tomotaka Sobue, Tetsuhisa Kitamura, Yuri Kitamura, Junko Ishihara, Ayaka Kotemori, Rong Liu, Sayaka Ikeda, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane and for the JPHC Study Group
Nutrients 2020, 12(9), 2503; https://doi.org/10.3390/nu12092503 - 19 Aug 2020
Cited by 15 | Viewed by 3627
Abstract
Acrylamide has been studied for its carcinogenicity in experimental animals, causing tumors at several organ sites, and has been considered probably carcinogenic to humans as well. Given the small number of epidemiological studies that have been conducted, it is still uncertain whether the [...] Read more.
Acrylamide has been studied for its carcinogenicity in experimental animals, causing tumors at several organ sites, and has been considered probably carcinogenic to humans as well. Given the small number of epidemiological studies that have been conducted, it is still uncertain whether the consumption of acrylamide is associated with liver cancer. Therefore, we investigated a study to determine the possible relationship between acrylamide intake and the risk of developing liver cancer in the Japanese population. A total of 85,305 participants, from the Japan Public Health Center-based Prospective Study, who provided a validated food-frequency questionnaire were enrolled between 1995 and 1998. During a median of 16.0 years follow-up, 744 new liver cancer cases were identified. Compared to the lowest tertile of acrylamide consumption (<4.8 µg/day), the multivariate hazard ratio (HR) for the highest tertile (≥7.6 µg/day) was 0.79 (95% confidence interval [CI] = 0.65–0.95) for liver cancer using multivariable model 1, adjusted for smoking status, body mass index (BMI), physical activity, medical history, and alcohol consumption; whereas the inverse relationship disappeared after additionally adjusting for coffee consumption in multivariable model 2 with HR of 1.08 (95% CI = 0.87–1.34) for the highest tertile. The effect of dietary acrylamide intake on the risk of liver cancer was not observed in the Japanese population. Full article
(This article belongs to the Special Issue The Association between Dietary Acrylamide Exposure and Cancer Risk)
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13 pages, 579 KiB  
Article
Dietary Acrylamide Intake and Risk of Lung Cancer: The Japan Public Health Center Based Prospective Study
by Rong Liu, Ling Zha, Tomotaka Sobue, Tetsuhisa Kitamura, Junko Ishihara, Ayaka Kotemori, Sayaka Ikeda, Norie Sawada, Motoki Iwasaki and Shoichiro Tsugane
Nutrients 2020, 12(8), 2417; https://doi.org/10.3390/nu12082417 - 12 Aug 2020
Cited by 12 | Viewed by 3282
Abstract
Acrylamide, which forms in heat-treated foods with high carbohydrate content, is a probable human carcinogen. This study aimed to evaluate the association between dietary acrylamide intake and lung cancer using data from the Japan Public Health Center based Prospective Study. Our study included [...] Read more.
Acrylamide, which forms in heat-treated foods with high carbohydrate content, is a probable human carcinogen. This study aimed to evaluate the association between dietary acrylamide intake and lung cancer using data from the Japan Public Health Center based Prospective Study. Our study included 85,303 participants who completed a food frequency questionnaire. Cox proportional hazards regression models were used to assess hazard ratios and 95% confidence intervals (CIs) after adjusting for confounders. After 14.3 years and 15.4 years of mean follow-up period, 1187 and 485 lung cancer cases were identified in men and women, respectively. The multivariable-adjusted hazard ratios of 10-µg/day increment in acrylamide intake were 1.01 (95% CI, 0.99–1.02) in men and 0.98 (95% CI, 0.95–1.02) in women. Compared with the lowest quartile of acrylamide intake, the hazard ratios for the highest quartile were 1.13 (95% CI, 0.95–1.33; p for trend = 0.12) in men and 1.03 (95% CI, 0.78–1.36; p for trend = 0.86) in women in the multivariable-adjusted model. Moreover, there was also no significant association observed in the stratified analysis for histological subtypes of lung cancer. This study demonstrated that dietary acrylamide intake was not associated with increased lung cancer risk in the Japanese population. Full article
(This article belongs to the Special Issue The Association between Dietary Acrylamide Exposure and Cancer Risk)
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