Recent Advances and Challenges in Tuberculosis Research
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Emerging Pathogens".
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 11825
Special Issue Editors
Interests: infection and immunity; host-pathogen interaction; bacterial pathogenesis; toxins; Mycobacterium tuberculosis
Special Issues, Collections and Topics in MDPI journals
Interests: membrane biophysics; protein structure and function; host–pathogen interactions; Mycobacterium tuberculosis; Staphylococcus aureus; enzymes; plant transcriptomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) that mainly affects the lungs but can affect other organs as well. The disease became a new challenge in 1985 after the emergence of HIV. According to WHO in 2019, 1.4 million patients died due to TB and close to 2 million people died due to COVID-19 in the year 2020. TB persists in two disease forms, asymptomatic latent TB and symptomatic active TB. With the evolution of drug-resistant strains and extremely drug-resistant strains, the global control of TB has become increasingly challenging.
Mtb is an intracellular pathogen that mainly infects macrophages. While the cellular and molecular mechanisms of Mtb pathogenesis are not fully understood, the bacillus persists in the macrophages through the following steps: (a) inhibiting the maturation of phagosome, (b) escaping from the phagolysosome into the cytosol, and (c) regulating host cell death and cell-to-cell spreading. Presently, with the rise of COVID-19, there are speculations that it can activate latent TB and pose a new threat in the time of pandemic.
On behalf of the Pathogens journal, you are cordially invited to contribute with an article to the Special Issue “Recent Advances and Challenges in Tuberculosis Research”. All research articles, reviews, minireviews, case reports, clinical cases, meta-analyses, and perspectives will be considered for publication after rigorous peer review.
Potential topics include but are not limited to the following:
- Co-infection with COVID-19 and TB;
- Mechanisms of intracellular survival of pathogenic mycobacteria;
- Immune responses to pathogenic mycobacteria;
- Mycobacterial regulation of cell death;
- Advances in vaccine development and therapeutics against tuberculosis.
Dr. Jianjun Sun
Dr. Supriyo Ray
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Mycobacterium tuberculosis
- Host-pathogen interaction
- Co-infection
- Toxins
- intracellular survival
- Immune responses
- Cell death
- Vaccine development
- Therapeutics
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