Nucleic Acids in Medicinal Chemistry
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (26 July 2023) | Viewed by 2540
Special Issue Editors
Interests: noncanonical nucleic acids; structural biology
Special Issues, Collections and Topics in MDPI journals
Interests: chemometrics; cell metabolomics
Interests: noncanonical nucleic acids; cellular and molecular biology; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Interests: cellular and molecular biology; noncanonical nucleic acids; autophagy; membrane trafficking
Interests: chemistry of nucleic acids; nucleic acids therapeutics; nucleic acid-targeting drugs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
For several decades, nucleic acids (NAs) have been of interest to the research communities of chemists and biochemists for their crucial role in storing genetic information, as well as in regulating a myriad of biological functions. Notably, NAs have become an attractive focus for medicinal chemists to develop novel therapeutical approaches using DNA and RNA as drug targets for their investigations. Interestingly, in the recent years, NAs turned out to be extremely versatile biomolecules revealing unique and unexpected biological functions and applications. Ranging from their use as therapeutic agents, as in the case of aptamers, to the covalent conjugation of functional ligands and the explosion as building blocks for constructing nanostructures, NAs have evolved from being just “genetic” material to represent “generic” material for several applications.The main purpose of this Special Issue is to encourage the submission and publication of rigorous research using state-of-the-art techniques as well as novel findings and recent advances in the field of nucleic acids. The related topics include DNA and RNA; gene therapy; artificial nucleic acids (morpholino, LNA, PNA, GNA, SNA, TNA, and HNA); antisense oligonucleotides; RNA interference; DNA-based nanomaterials for drug delivery; aptamers; theranostics; nucleic acid-based biosensors; fluorescent nucleic acids; oligonucleotide conjugates; noncanonical DNA structures (G-quadruplex, i-motif, Holliday junction, and triplex); nucleic acid-targeting drugs; nucleoside and nucleotide analogs and modifications. The collection of manuscripts will be published as a Special Issue of Pharmaceuticals. The range of topics in this Special Issue accurately reflects the vigor of current investigations in the “hot” area of nucleic acids and underlines the expanding opportunities for medicinal chemistry in this central discipline. Prof. Antonio RandazzoProf. Jussara AmatoDr. Stefano De TitoDr. Nunzia IaccarinoDr. Anna Di Porzio
Prof. Dr. Antonio Randazzo
Dr. Nunzia Iaccarino
Dr. Anna Di Porzio
Dr. Stefano De Tito
Prof. Dr. Jussara Amato
Guest Editors
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Keywords
- DNA
- RNA
- Artificial nucleic acids (morpholino, LNA, PNA, GNA, SNA, TNA, HNA)
- Antisense
- RNA interference
- DNA-based nanomaterials for drug delivery
- Aptamers
- Theranostics
- Nucleic acid-based biosensors
- Fluorescent nucleic acids
- Oligonucleotide conjugates
- Noncanonical DNA structures (G-quadruplex, i-motif, Holliday junction, triplex)
- Nucleic acid-targeting drugs
- Nucleoside and nucleotide analogs and modifications
- Gene therapy
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