Advanced Electrochemical Sensors in Drug Sensing

A special issue of Pharmaceuticals (ISSN 1424-8247).

Deadline for manuscript submissions: closed (31 July 2019)

Special Issue Editor


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Guest Editor
Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinskeho 9, 812 37 Bratislava, Slovakia
Interests: electroanalytical chemistry; electroanalysis; electrochemical (bio)sensors; progressive sensing materials

Special Issue Information

Dear Colleagues,

One of the main goals of modern analytical chemistry consists in an application of rapid high throughput methods and procedures at the small and miniaturized scale, accompanied by simultaneous reduction in the number of experiments/measurements, time of analysis, energy and reagent consumption. Accordingly, modern electrochemical methods have proven to be comfortable and beneficial analytical tool for trace determination of various substances owing to the simplicity, fast response, low cost, technology based on green chemistry, miniaturization and possibility to on-line field monitoring. Despite the useful utilization of conventional electrode materials (mercury, glassy carbon, graphite, carbon paste), the electrochemists, material engineers and nanotechnologists are constantly forced to investigate and develop material platforms as electrode substrates for perspective and fool-proof electrochemical sensors in various applications. The recent popularity and availability of electrochemical methods could make them one of the most frequently used methods in the field of pharmaceutical analysis. Nowadays, the effectiveness, safety and tolerability of various drugs are in accordance with the benefit and risk evaluation in clinical practise. Taking into consideration the pharmaceutical relevance and medicinal objectives of miscellaneous drugs, novel analytical approaches based on application of progressive electrochemical sensors of high efficiency for rigid control of drugs in pharmaceutical and clinical practise are still desired. This Special Issue has the main aim to reflect the latest findings in drug sensing using novel and advanced electrochemical sensors as well as to outline future aspects in this field.

Dr. Ľubomír Švorc
Guest Editor

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Keywords

  • modern electrochemical methods
  • novel electrode material
  • drug sensing
  • analytical sensitivity
  • analytical selectivity

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Published Papers (1 paper)

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Research

11 pages, 1631 KiB  
Article
Voltammetric Evaluation of Diclofenac Tablets Samples through Carbon Black-Based Electrodes
by Carlos Eduardo Peixoto da Cunha, Edson Silvio Batista Rodrigues, Morgana Fernandes Alecrim, Douglas Vieira Thomaz, Isaac Yves Lopes Macêdo, Luane Ferreira Garcia, Jerônimo Raimundo de Oliveira Neto, Emily Kussmaul Gonçalves Moreno, Nara Ballaminut and Eric de Souza Gil
Pharmaceuticals 2019, 12(2), 83; https://doi.org/10.3390/ph12020083 - 4 Jun 2019
Cited by 17 | Viewed by 4375
Abstract
Diclofenac (DIC) is a non-steroidal anti-inflammatory drug of wide use around the world. Electroanalytical methods display a high analytical potential for application in pharmaceutical samples but the drawbacks concerning electrode fouling and reproducibility are of major concern. Henceforth, the aim of this work [...] Read more.
Diclofenac (DIC) is a non-steroidal anti-inflammatory drug of wide use around the world. Electroanalytical methods display a high analytical potential for application in pharmaceutical samples but the drawbacks concerning electrode fouling and reproducibility are of major concern. Henceforth, the aim of this work was to propose the use of alternative low-cost carbon black (CB) and ionic liquid (IL) matrix to modify the surface of pencil graphite electrodes (PGE) in order to quantify DIC in raw materials, intermediates, and final products, as well as in stability assays of tablets. The proposed method using CB+IL/PGE displayed good recovery (99.4%) as well as limits of detection (LOD) of 0.08 µmol L-1 and limits of quantification (LOQ) of 0.28 µmol L−1. CB+IL/PGE response was five times greater than the unmodified PGE. CB+IL-PGE stands as an interesting alternative for DIC assessment in different pharmaceutical samples. Full article
(This article belongs to the Special Issue Advanced Electrochemical Sensors in Drug Sensing)
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