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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Characterization and Quality Control of Biopharmaceuticals Using the Multi-Attribute Method (MAM): Advantages and Challenges

edited by Jingzhong Guo

submission deadline 31 May 2025 | Viewed by 33 | Submission Open

Keywords: analytical characterization; critical quality attribute (CQA); the multi-attribute method (MAM); new peak detection (NPD); post-translational modifications (PTM); product quality attribute (PQA); peptide mapping (PM); quality by design (QbD); quality control (QC); structure– activity relationship (SAR)

(This special issue belongs to the Section Biopharmaceuticals)

Pharmacotherapy of Endometriosis

edited by

Jang-Kyung Park

, Dong Il Kim and

Soo-Hyun Sung

submission deadline 31 May 2025 | Viewed by 28 | Submission Open

Keywords: endometriosis; pharmacotherapy; integrative medicine; herbal medicine herbal formulations; plant-based compounds; herbal extracts; pharmacopuncture; pelvic pain; infertility

(This special issue belongs to the Section Pharmacology)

Topoisomerases as Targets for Novel Drug Discovery

edited by

Andrej Perdih

submission deadline 20 Jun 2025 | 8 articles | Viewed by 23501 | Submission Open

Keywords: topoisomerase; type I topoisomerase; type II topoisomerase; DNA Gyrase; DNA topology; catalytic inhibitors; topo II poisons; DNA gyrase inhibitors; Novel bacterial topoisomerase inhibitors (NBTI); anticancer agents; antibacterial agents

(This special issue belongs to the Section Medicinal Chemistry)

Novel Strategies in Gangliosidoses Therapy

edited by Jeanine Jarnes

submission deadline 22 Jun 2025 | Viewed by 232 | Submission Open

Keywords: gangliosidoses; small molecules; gene therapies; enzyme replacement; palliative care

(This special issue belongs to the Section Pharmacology)

New Advances in Antiarrhythmic Drugs

edited by

Norbert Szentandrássy

submission deadline 25 Jun 2025 | 7 articles | Viewed by 11551 | Submission Open

Keywords: antiarrhythmic drugs; ion channel blockers; cardiac action potential; sudden cardiac death; cardiac arrhythmia; proarrhythmic action

(This special issue belongs to the Section Pharmacology)

Medicinal Chemistry of Metal Complexes: Design, Synthesis and Evaluation

edited by Bojana B. Zmejkovski,

Goran Kaluđerović

and

Nebojša Pantelić

submission deadline 25 Jun 2025 | Viewed by 107 | Submission Open

Keywords: metal complexes; medicinal chemistry; bioinorganic chemistry; coordination chemistry; organometallics; metal-based drugs; biological activity; toxicology; biomedical application; drug delivery

(This special issue belongs to the Section Medicinal Chemistry)

Pharmaceuticals for Inflammatory Bowel Disease (IBD)

edited by

Phurpa Wangchuk

submission deadline 25 Jun 2025 | Viewed by 103 | Submission Open

Keywords: inflammatory bowel disease; IBD symptoms; IBD pathogenesis; IBD treatments

(This special issue belongs to the Section Pharmacology)

Pediatric Drug Therapy: Safety, Efficacy, and Personalized Medicine

edited by

Catherine M. T. Sherwin

submission deadline 25 Jun 2025 | Viewed by 31 | Submission Open

Keywords: pediatric pharmacotherapy; drug safety in children; pediatric drug efficacy; personalized medicine in pediatrics; pediatric pharmacokinetics; pediatric pharmacodynamics; pharmacogenomics in children; pediatric clinical trials; pediatric dosing strategies; pediatric drug formulations

(This special issue belongs to the Section Pharmacology)

Boron-Containing Compounds: Identification, Synthesis, Biological Actions and Pharmacology

edited by

Marvin Antonio Soriano-Ursúa

and

Andrei Biță

submission deadline 30 Jun 2025 | Viewed by 160 | Submission Open

Keywords: boron; drug development; drug discovery; bioactive boron compounds; bioinorganic chemistry; inorganic biological chemistry; synthesis; natural boron compounds; chemical characterization

(This special issue belongs to the Section Medicinal Chemistry)

Integrating Medicinal Chemistry and Mass Spectrometry: New Opportunities and Challenges

edited by

Francesco Fiorentino

submission deadline 30 Jun 2025 | Viewed by 122 | Submission Open

Keywords: drug discovery; medicinal chemistry; mass spectrometry; chemical biology; structural biology

(This special issue belongs to the Section Medicinal Chemistry)

A Commemorative Special Issue in Honor of Professor Carlos Alberto Manssour Fraga: Medicinal Chemistry’s Efforts to Discover Novel Bioactive Molecules for Complex Diseases

edited by Luzineide Tinoco and

Pedro De Sena Murteira Pinheiro

submission deadline 30 Jun 2025 | Viewed by 15 | Submission Open

Keywords: medicinal chemistry; bioactive molecules; complex diseases; cardiovascular diseases; diabetes; cancer; neurodegenerative disorders; drug discovery; synthetic chemistry; target identification; structure– activity relationship; preclinical evaluation

(This special issue belongs to the Section Medicinal Chemistry)

Organ Regeneration by Application of Biomaterials and Stem Cells Technology Tools

edited by

Saima Imran

submission deadline 12 Jul 2025 | 1 articles | Viewed by 1729 | Submission Open

Keywords: stem cells; biomaterial; biocompatibility; regenerative medicine; tissue engineering; acellular matrix; decellularization; disease modeling

(This special issue belongs to the Section Biopharmaceuticals)

Neuroblastoma Pathogenesis and Therapy

edited by

Saurabh Agarwal

submission deadline 20 Jul 2025 | 3 articles | Viewed by 12175 | Submission Open

Keywords: Neuroblastoma; Pediatric cancers; Neural crest; Pathogenesis; Metastasis; Epigenetics; Therapeutic approach; Tumorigenesis; Signaling mechanisms; Epithelial-to-mesenchymal transition

(This special issue belongs to the Section Pharmacology)

Novel Imidazole Derivatives in Medicinal Chemistry

edited by Dorota Olender,

Justyna Żwawiak

and

Lucjusz Zaprutko

submission deadline 25 Jul 2025 | 1 articles | Viewed by 2303 | Submission Open

Keywords: imidazole; nitroimidazole derivatives; biological activities; synthesis; heterocyclic drug discovery

(This special issue belongs to the Section Medicinal Chemistry)

2D and 3D Culture Systems: Current Trends and Biomedical Applications

edited by

Juliana Mara Serpeloni

, Colus Ilce Mara and

Diego Luís Ribeiro

submission deadline 25 Jul 2025 | 1 articles | Viewed by 2168 | Submission Open

Keywords: spheroids; organoids; 3D cultures; tissue engineering; disease modelling; regenerative medicine; cell-extracellular matrix interaction; drug screening

(This special issue belongs to the Section Biopharmaceuticals)

Natural Products as an Alternative for Treatment of Human Diseases

edited by Eduardo Lira,

Jackson Guedes

and Raimundo Gonçalves De Oliveira Junior

submission deadline 25 Jul 2025 | Viewed by 49 | Submission Open

Keywords: medicinal plants; herbal remedies; natural products; traditional medicine

(This special issue belongs to the Section Natural Products)

Photodynamic Therapy: 3rd Edition

edited by

Céline Frochot

submission deadline 25 Jul 2025 | Viewed by 32 | Submission Open

Keywords: photodynamic therapy; photosensitizers; nanoparticles; photo-diagnosis; targeting; antimicrobial; X-rays excitation; two photon and upconversion; immunomodulation; dosimetry; hypoxia

(This special issue belongs to the Section Pharmaceutical Technology)

Recent Advances in Cancer Diagnosis and Therapy

edited by

Adriana Grigoraș

and

Hsin-Sheng Yang

submission deadline 30 Jul 2025 | Viewed by 207 | Submission Open

Keywords: early diagnosis; advanced therapy; biomarkers; immunohistochemistry; molecular diagnosis; metastasis; prognosis; targeted therapies; combination therapies; cancer pharmacology

(This special issue belongs to the Section Pharmacology)

Pharmacological Advances for Treatment in Hypertension 2.0

edited by

Arquimedes Gasparotto Junior

submission deadline 31 Jul 2025 | 2 articles | Viewed by 2857 | Submission Open

Keywords: antihypertensive; cardioprotective; herbal medicine; hypertension; medicinal plants

(This special issue belongs to the Section Pharmacology)

The Application of Pharmacogenetics in Toxicity Prevention and Drug Effect Improvement

edited by Pura Ballester

submission deadline 31 Jul 2025 | Viewed by 291 | Submission Open

Keywords: pharmacogenetics; drug toxicity prevention; efficacy enhancement; pharmaceutical research; precision medicine; therapeutic optimization

(This special issue belongs to the Section Pharmacology)

Challenges in the Development of PET and SPECT Radiotracers: Innovative Ideas with Negative Outcomes

edited by Magali Toussaint and Barbara Wenzel

submission deadline 25 Sep 2025 | Viewed by 228 | Submission Open

Keywords: radiotracer development; positron emission tomography (PET); single-photon emission computed tomography (SPECT); negative results; diagnostic radiotracers; therapeutic radiopharmaceuticals; radiolabeling; automated synthesis and GMP; pre-clinical studies; medicinal chemistry

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Heterocyclic Compounds in Medicinal Chemistry, 2nd Edition

edited by

Valentina Noemi Madia

and

Davide Ialongo

submission deadline 25 Sep 2025 | Viewed by 109 | Submission Open

Keywords: heterocycles; drug design; drug discovery; bioactive compounds; structure-based drug design; structure– activity relationship; in silico studies; ADMET properties; multicomponent reactions; phytochemicals

(This special issue belongs to the Section Medicinal Chemistry)

Innovative Analytical Techniques and Nanotechnology in Natural Products Analysis and Drug Development

edited by Jinchao Wei and

Di Chen

submission deadline 30 Sep 2025 | Viewed by 109 | Submission Open

Keywords: natural product; Chinese medicine; drug development; analytical technique; nanotechnology; spectrometry; chromatography; sensors; formulation

(This special issue belongs to the Section Natural Products)

Advances in Pharmacotherapy for Nasal Disorders in Rhinology

edited by

Elena Cantone

submission deadline 30 Sep 2025 | Viewed by 61 | Submission Open

Keywords: rhinology; CRS; asthma; nasal polyps; biologics; airflow; children; QoL; artificial intelligence; olfaction; chemical senses

(This special issue belongs to the Section Pharmacology)

Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology

edited by David Hecht

submission deadline 22 Oct 2025 | Viewed by 45 | Submission Open

Keywords: protein kinases inhibitor resistance; structural biology of of protein kinases; computational modeling; drug design; preclinical and clinical studies; precision oncology; ALK resistance for personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

PET/CT for Diagnosis, Treatment Planning and Prognosis Prediction in Oncology and Inflammatory Diseases

edited by

Alessio Rizzo

and