Chitosan-Based Nanoparticles as Carriers for Drug Delivery and Biomedical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 523

Special Issue Editors


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Guest Editor
Department of Drugs and Pharmaceutics, School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil
Interests: nanoparticles; chitosan; drug delivery

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Guest Editor
Faculty of Pharmaceutical Sciences, São Paulo State University, 14800-903 Araraquara, SP, Brazil
Interests: nanotechnology-based systems; bioadhesive systems; quality control
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, I-41125 Modena, Italy
Interests: drug delivery; nanoparticle; liposome; chitosan

Special Issue Information

Dear colleagues,

Chitosan is a promising biomaterial used in the development of different types of health technologies. Due to its mucoadhesive and cell membrane modulating properties, nanoparticles produced from chitosan are extensively researched as an alternative carrier system for different routes of administration. Fundamental and technological research on chitosan nanoparticles has evolved, forming an extensive repertoire of knowledge about the mechanisms of formation and action of this system, as well as problems relating to toxicology, regulatory and scaling difficulties. Therefore, this Special Issue is dedicated to the publication of original articles and reviews focused on the science and technology of chitosan-based nanoparticles for drug delivery and other biomedical applications. Research works that provide updates on the scientific foundations that guide the formation of chitosan nanoparticles and the main mechanisms of biological interaction are welcome. Furthermore, equally relevant are studies that aim to further advance the technological development of chitosan nanoparticles as a platform for treating different types of diseases. The relevant topics include pre-formulation studies; questions about production and scale-up; problems relating to quality control, stability studies and regulatory systems; new applications; and anti-cancer, anti-inflammatory and nanotoxicological effects.

Dr. Aline Martins dos Santos
Dr. Leonardo Miziara Barboza Ferreira
Dr. Eleonora Maretti
Guest Editors

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Keywords

  • chitosan
  • nanoparticles
  • pre-formulation
  • drug delivery
  • anti-cancer
  • anti-inflammatory
  • biomedical applications

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Published Papers (1 paper)

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Research

16 pages, 5113 KiB  
Article
Tailoring Mesalazine Nanosuspension Using Chitosan Polyelectrolyte Complexes with Alginate and Alginate/Hydroxypropyl-Methylcellulose Phthalate
by Amélia Aparecida Rocca Pereira, José Vitor Melchiades Aparecida, Maria Eduarda Ramalho, Leonardo Miziara Barboza Ferreira and Maria Palmira Daflon Gremião
Pharmaceutics 2024, 16(12), 1489; https://doi.org/10.3390/pharmaceutics16121489 - 21 Nov 2024
Viewed by 244
Abstract
Background/Objectives: This study evaluated how the relative proportion of chitosan (CS) to the polyanions alginate (ALG) and hydroxypropyl-methylcellulose phthalate (HP) affects the colloidal properties of mesalazine (MSZ) nanosuspensions as a strategy to produce particles with specific characteristics. Methods: Nanosuspensions were prepared [...] Read more.
Background/Objectives: This study evaluated how the relative proportion of chitosan (CS) to the polyanions alginate (ALG) and hydroxypropyl-methylcellulose phthalate (HP) affects the colloidal properties of mesalazine (MSZ) nanosuspensions as a strategy to produce particles with specific characteristics. Methods: Nanosuspensions were prepared using a bottom–up approach based on acid–base reactions and were modified with CS in a binary mixture with ALG or a ternary mixture with ALG and HP. The particle size, polydispersity index (PDI), zeta potential, morphology, and drug association efficiency were analyzed. Results: Higher proportions of CS relative to the polyanions resulted in smaller, less polydisperse particles. The zeta potential inversion was influenced by the relative proportion of CS in the system. These results were consistent over 30 days and pH exerted an influence on the magnitude of the observed effect. The optimized NS modified with binary CS/ALG blends had the following properties at pH 6.0: an average particle size of 324.9 nm, PDI of 0.5, and zeta potential of +40.8 mV; at pH 4.0, it had an average particle size of 310.4 nm, PDI of 0.4, and zeta potential of +43.6 mV. The optimized NS modified with ternary CS/ALG/HP had the following properties at pH 6.0: an average particle size of 316.7 nm, PDI of 0.5, and zeta potential of +33.9 mV; at pH 4.0, it had an average particle size of 363.5 nm, PDI of 0.6, and zeta potential of +33.9 mV. Conclusions: CS-based polyelectrolyte complexes with ALG and ALG/HP offer an approach to modulating the properties of MSZ nanosuspensions, enabling the production of particles with tailored characteristics. Full article
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