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Pharmaceutics
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Nanocomposites as Implantable Devices or Drug Delivery Platforms: A New...
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Nanocomposites as Implantable Devices or Drug Delivery Platforms: A New Insight into Treat Dental and Oral Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1656

Special Issue Editors

Dr. Giuseppe Angellotti

E-Mail Website
Guest Editor
Institute of Nanostructured Materials, National Research Council (CNR-ISMN), Piazzale Aldo Moro, 7, 00185 Roma, Italy
Interests: nanomaterials; drug delivery system; natural compound
Dr. Giulia Di Prima

E-Mail Website
Guest Editor
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90123 Palermo, Italy
Interests: ex-vivo permeation; nanosystems; drug delivery systems; biopolymers; buccal tablets; microparticles; dissolution kinetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanocomposites are multiphase materials where at least one component is in the nano-scale range. Due to their unique properties, they are currently spotlighted as versatile and innovative dosage forms. Specifically, their mechanical, physical, and chemical properties, biocompatibility, and adaptable composition could represent a new frontier in the local/loco-regional treatment of dental and oral diseases. Their multifunctional components could determine targeted drug delivery and co-administration of incompatible actives, offering innovative treatment options for periodontitis, oral lichen planus (OLP), medication-related osteonecrosis of the jaw (MRONJ), and oral cancers (e.g., OSCC). Nanocomposites can mitigate any systemic side effect by ensuring localized and controlled release of synthetic drugs and natural compounds with pronounced anti-inflammatory, antioxidant, anticancer, wound healing, antibiotic, and osteoinductive activities while improving treatment effectiveness and success. These results could be achieved by carefully designing the whole nanocomposite which could be used as such or as covering material for implantable devices (e.g., titanium-based) or bone substitutes (e.g., hydroxyapatite). Each component's accurate choice will lead to the desired characteristics, e.g., longevity, osteointegration, in situ solidification, mucoadhesion, controlled drug release, etc.

This Special Issue will cover all the advances, challenges, and future perspectives in using actives-loaded nanocomposites to manage dental and oral diseases. Literature reviews and research papers concerning developing nanocomposite-based innovative drug delivery systems (e.g., bone substitutes, covering materials, gingival patches of films, periodontal injectable in situ gelling matrices, etc.) are welcome.

We look forward to receiving your contributions.

Dr. Giuseppe Angellotti
Dr. Giulia Di Prima
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental implant
  • covering materials
  • bone substitutes
  • scaffold
  • antioxidant
  • anti-inflammatory
  • nanocomposite
  • controlled release
  • dental and oral diseases
  • patches and films
  • injectable in situ gelling formulations
  • biocompatibility
  • tissue regeneration
  • anticancer

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Published Papers (2 papers)

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Research

24 pages, 2695 KiB  
Article
Hybrid Nanocomposite Mini-Tablet to Be Applied into the Post-Extraction Socket: Matching the Potentialities of Resveratrol-Loaded Lipid Nanoparticles and Hydroxyapatite to Promote Alveolar Wound Healing
by Viviana De Caro, Giada Tranchida, Cecilia La Mantia, Bartolomeo Megna, Giuseppe Angellotti and Giulia Di Prima
Pharmaceutics 2025, 17(1), 112; https://doi.org/10.3390/pharmaceutics17010112 - 15 Jan 2025
Viewed by 647
Abstract
Background/Objectives: Following tooth extraction, resveratrol (RSV) can support healing by reducing inflammation and microbial risks, though its poor solubility limits its effectiveness. This study aims to develop a solid nanocomposite by embedding RSV in lipid nanoparticles (mLNP) within a hydrophilic matrix, to [...] Read more.
Background/Objectives: Following tooth extraction, resveratrol (RSV) can support healing by reducing inflammation and microbial risks, though its poor solubility limits its effectiveness. This study aims to develop a solid nanocomposite by embedding RSV in lipid nanoparticles (mLNP) within a hydrophilic matrix, to the scope of improving local delivery and enhancing healing. Hydroxyapatite (HXA), often used as a bone substitute, was added to prevent post-extraction alveolus volume reduction. Methods: The mLNP-RSV dispersion was mixed with seven different polymers in various mLNP/polymer ratios. Following freeze-drying, the powders were redispersed, and the resulting dispersions were tested by DLS experiments. Then, the best two nanocomposites underwent extensive characterization by SEM, XRD, FTIR, Raman spectroscopy, and thermal analysis as well as in vitro partitioning studies aimed at verifying their ability to yield the mLNP-RSV from the hydrophilic matrix to a lipophilic tissue. The characterizations led to identify the best nanocomposite, which was further combined with HXA to obtain hybrid nanocomposites, further evaluated as pharmaceutical powders or in form of mini-tablets. Results: PEG-based nanocomposites emerged as optimal and, following HXA insertion, the resulting powders revealed adequate bulk properties, making them useful as a pharmaceutical intermediate to produce ≈59 mm3 mini-tablets, compliant with the post-extraction socket. Moreover, they were proven ex vivo to be able to promote RSV and GA accumulation into the buccal tissue over time. Conclusions: The here-proposed mini-tablet offers an innovative therapeutic approach for alveolar wound healing promotion as they led to a standardized dose administration, while being handy and stable in terms of physical solid identity as long as it takes to suture the wound. Full article
(This article belongs to the Special Issue Nanocomposites as Implantable Devices or Drug Delivery Platforms: A New Insight into Treat Dental and Oral Diseases)
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16 pages, 8617 KiB  
Article
Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy
by Marcelo Matos Rocha, Valesca Sander Koth, Marcela Wiltgen Jeffman, Fernanda Gonçalves Salum, Josiane de Almeida, Karina Cesca and Karen Cherubini
Pharmaceutics 2025, 17(1), 24; https://doi.org/10.3390/pharmaceutics17010024 - 26 Dec 2024
Viewed by 664
Abstract
Objectives: This work investigated the effect of bacterial nanocellulose (BNC) alone or with chemisorbed chlorhexidine or povidone-iodine on post-tooth extraction repair in rats undergoing bisphosphonate therapy. Methods: Forty Wistar rats were treated with zoledronic acid, subjected to tooth extractions and allocated [...] Read more.
Objectives: This work investigated the effect of bacterial nanocellulose (BNC) alone or with chemisorbed chlorhexidine or povidone-iodine on post-tooth extraction repair in rats undergoing bisphosphonate therapy. Methods: Forty Wistar rats were treated with zoledronic acid, subjected to tooth extractions and allocated into groups according to the material inserted in the post-extraction socket: (1) BNC (n = 10); (2) BNC/Iodine (n = 10); (3) BNC/Chlorhex (n = 10); (4) Control (n = 10). Maxillae were dissected and macro- and microscopically analyzed. Results: Oral lesion frequency on macroscopic examination did not differ between the groups, whereas it was larger in the BNC/Iodine group compared to the BNC/Chlorhex and Control. BNC/Chlorhex had significantly more connective tissue than did BNC but did not differ from the BNC/Iodine and Control. Epithelium, vital bone, non-vital bone, tooth fragment and inflammatory infiltrate did not significantly differ between the groups. BNC/Iodine showed greater CD31 immunostaining compared to BNC and the Control. Myeloperoxidase staining did not differ between the groups, and scanning electron microscopy analysis showed similar characteristics in all groups. Conclusions: BNC with chemisorbed povidone-iodine is associated with increased vascularization in post-extraction wounds of rats undergoing bisphosphonate therapy, whereas BNC with chemisorbed chlorhexidine improves connective tissue formation. BNC works as an effective carrier for the antiseptics tested. Full article
(This article belongs to the Special Issue Nanocomposites as Implantable Devices or Drug Delivery Platforms: A New Insight into Treat Dental and Oral Diseases)
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