Pharmaceuticals Based on or Loaded with Natural Products

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 3830

Special Issue Editor


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Guest Editor
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90123 Palermo, Italy
Interests: ex-vivo permeation; nanosystems; drug delivery systems; biopolymers; buccal tablets; microparticles; dissolution kinetics
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Special Issue Information

Dear Colleagues,

According to the UN Agenda 2030, several actions (corresponding to 17 Sustainable Development Goals—SDGs) could be taken to act synergistically towards various areas of critical importance for both humanity and the planet. Nowadays, a growing trend is to recover waste, in accordance with a circular economy model, by means of extraction of the loaded or residual natural bioactive compounds (e.g., polyphenols, carotenoids, plant sterols and stanols, anthraquinones, astaxanthin), polymers (e.g., chitosan, hyaluronic acid, pectin), proteins (e.g., collagen, gelatine, fish protein hydrolysate), DNA fractions, lipids, vitamins, etc.  These molecules can be successfully used to produce pharmaceuticals as they can exert a wide range of potent biological activities (e.g., antioxidant, antimicrobic, anti-inflammatory, wound healing, antiaging, anti-hyperpigmentation, photoprotective, chemopreventive, anticancer and immunomodulatory) while also being quite safe.

This Special Issue will collect both scientific research papers and review articles focused on the use of the aforementioned natural products obtained by waste recovery to develop pharmaceutical products useful for several purposes. Dermatologic, transdermic, mucosal and oral formulations as well as micro- and nanotechnology-based delivery systems are welcome. The central natural products could be intended as actives (e.g., polyphenols, DNA fractions, fish protein hydrolysate, etc.) or as natural materials to develop the formulation or the nano- and micro-particulate delivery systems (e.g., gelatin, chitosan, hyaluronic acid, pectin, etc.). Contributions to the expansion of knowledge in this context are of great appeal in the pharmaceutical field while also being in agreement with the current “green” trend.

Dr. Giulia Di Prima
Guest Editor

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Keywords

  • phytochemicals
  • biopolymers
  • antioxidants
  • pharmaceuticals
  • secondary raw materials
  • dermatologic formulations
  • transdermic formulations
  • mucosal formulations
  • oral formulations
  • micro- and nano-delivery systems

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Published Papers (1 paper)

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36 pages, 4769 KiB  
Review
Recent Advancements in Gallic Acid-Based Drug Delivery: Applications, Clinical Trials, and Future Directions
by Ranjit K. Harwansh, Rohitas Deshmukh, Vijay Pratap Shukla, Dignesh Khunt, Bhupendra Gopalbhai Prajapati, Summya Rashid, Nemat Ali, Gehan M. Elossaily, Vijendra Kumar Suryawanshi and Arun Kumar
Pharmaceutics 2024, 16(9), 1202; https://doi.org/10.3390/pharmaceutics16091202 - 13 Sep 2024
Cited by 1 | Viewed by 3391
Abstract
Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, and strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, [...] Read more.
Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, and strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, etc. Apart from its incredible therapeutic benefits, it has been associated with low permeability and bioavailability issues, limiting their efficacy. GA belongs to BCS (Biopharmaceutics classification system) class III (high solubility and low probability). In this context, novel drug delivery approaches played a vital role in resolving these GA issues. Nanocarrier systems help improve drug moiety’s physical and chemical stability by encapsulating them into a lipidic or polymeric matrix or core system. In this regard, researchers have developed a wide range of nanocarrier systems for GA, including liposomes, transfersomes, niosomes, dendrimers, phytosomes, micelles, nanoemulsions, metallic nanoparticles, solid lipid nanoparticles (SLNs), nanoparticles, nanostructured lipid carriers, polymer conjugates, etc. In the present review, different search engines like Scopus, PubMed, ScienceDirect, and Google Scholar have been referred to for acquiring recent information on the theme of the work. Therefore, this review paper aims to emphasize several novel drug delivery systems, patents, and clinical updates of GA. Full article
(This article belongs to the Special Issue Pharmaceuticals Based on or Loaded with Natural Products)
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