Oromucosal Dosage Forms: Novel Formulation Strategies, Delivery and Release
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2716
Special Issue Editors
Interests: controlled drug release; bio-adhesive buccal delivery systems; sublingual delivery; lipid-micro and nanoparticles; drug absorption from the oral cavity
Special Issues, Collections and Topics in MDPI journals
Interests: ex-vivo permeation; nanosystems; drug delivery systems; biopolymers; buccal tablets; microparticles; dissolution kinetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the last few decades, the oral cavity has attracted the interest of the scientific community as a promising alternative route for drug administration. Indeed, the oral mucosa could be particularly interesting for the treatment of local affections as well as for systemic therapies via precisely designed formulations and careful selection of the application site. Both the buccal and sublingual mucosae are highly vascularized, presenting several advantages such as the opportunity to bypass the gastrointestinal tract and first-pass metabolism in the liver. When the sublingual mucosa is chosen as an administration site, the rapid onset of action results in the delivery route being more comfortable and convenient than the intravenous route. Moreover, mouth pathologies ranging from periodontitis to mucositis up to cancerous lesions can greatly benefit from targeted locoregional drug delivery in a manner whereby systemic side effects are avoided, which enhances the patient’s quality of life.
To obtain significant therapeutic results, the design and characterization of innovative pharmaceutical dosage forms suitable for oral cavity application are of crucial importance. This includes the choice of innovative compositions, production techniques and drug release mechanisms.
Therefore, this Special Issue welcomes original research articles and reviews that cover all the aspects of the design, manufacturing, characterization and final formulation of oromucosal drug delivery systems specifically designed to be applied on the oral cavity both for systemic and locoregional therapies.
Research areas of interest include (but are not limited to) the following technologies: film, patch, matrix tablet, nanocomposite, IPEC and microparticles.
Dr. Viviana De Caro
Dr. Giulia Di Prima
Guest Editors
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Keywords
- buccal route
- sublingual route
- oromucosal delivery
- mucoadhesion
- mucosal permeability
- drug delivery systems
- kinetics of drug release
- mechanism of drug discharge
- systemic therapy
- locoregional buccal treatment
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