Transdermal/Dermal Drug Delivery System
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 7998
Special Issue Editor
Interests: transdermal/dermal drug delivery; topical delivery; skin barrier; follicular delivery; nanocarriers; microneedles; skin diseases
Special Issue Information
Dear Colleagues,
Transdermal/dermal drug delivery is developed for systemic/topical disease treatment, which delivers drugs through the skin or directly to the skin lesions to avoid gastrointestinal tract enzymatic digestion and liver first-pass metabolism, reduce gastrointestinal tract irritation, and improve patient compliance. It is one of the most favorable methods among novel drug delivery systems because it has been widely used to treat systemic diseases and topical diseases. Moreover, skin diseases in topical diseases are the fourth leading cause of nonfatal and chronic disease, such as bacterial and fungal infections, psoriasis, dermatitis, eczema, vitiligo, oxidative damage, aging, alopecia, and skin cancer.
However, the stratum corenum (SC) in the upmost layer of the skin is a barrier against pathogens, but also drugs or drug-carrier diffusion. Therefore, to safely overcome the SC barrier and to efficiently deliver drugs across the SC still remain as challenges. Many strategies are designed to solve the issue including physical, chemical, and pharmaceutical methods. Among them, nanocarrier- or microneedle- mediated transdermal delivery systems are attractive advanced technologies. Nanocarrier-based transdermal delivery systems include lipid-based (nanoemulsions, microemulsions, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs)), and vesicular carriers (non-deformable, such as liposomes, niosomes, emulsomes and cerosomes, and deformable, such as transfersomes, ethosomes, transethosomes, and penetration enhancer vesicles). They can encapsulate drugs, promote skin penetration with controlled or on-demand drug release properties, and improve treatment outcomes. Microneedles can pierce the skin and deliver drugs to the dermis in a painless and minimum-invasive manner, and they combine the benefits of both topical-transdermal and injectable drug administration approaches. Furthermore, the combination of nanocarriers with microneedles can formulate a more advanced transdermal/dermal delivery system with integrated advantages.
The present Special Issue serves as an overview of current research on transdermal/dermal drug delivery systems, as strategies and formulative approaches to treat systemic and topical diseases, the overcoming SC barrier and the enhanced transdermal/dermal delivery or permeation of drugs.
Prof. Dr. Yuehong Xu
Guest Editor
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Keywords
- transdermal/dermal drug delivery
- topical delivery
- skin barrier
- follicular delivery
- nanocarriers
- microneedles
- skin diseases
- permeation enhancing
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