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Pharmaceutics
Special Issues
Editorial Board Members’ Collection Series: Image-Guided and Targeted Theranostic Platforms
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Editorial Board Members’ Collection Series: Image-Guided and Targeted Theranostic Platforms

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 5776

Special Issue Editors

Dr. Murali Mohan Yallapu

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Guest Editor
Department of Immunology and Microbiology, College of Medicine, University of Texas Rio Grade Valley, McAllen, TX 78503, USA
Interests: cancer therapy; drug delivery; drug targeting; infectious disease; micelle; nanoparticles; nanotechnology; polymers; targeted therapies; HIV; antibody engineering; antibody–drug conjugates
Special Issues, Collections and Topics in MDPI journals
Dr. Nicolas Anton

E-Mail Website1 Website2
Guest Editor
INSERM, UMR 1260, Regenerative Nanomedicine (RNM), University of Strasbourg, F-67000 Strasbourg, France
Interests: nano-emulsion; emulsion; nanoparticle; molecular imaging; drug delivery systems; theranostics; targeting; physicalchemistry of colloids and interfaces

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue on “Image-Guided and Targeted Theranostic Platforms” in the medical field. This Special Issue intends to provide a unique collection of the latest research accomplishments in the field of imaging, diagnosis, therapy, and nanotheranostics.

Nanotechnology has offered new avenues in the development of new imaging, diagnostic, and targeted therapeutic formulations that target a number of diseases, including cancer. Nanoparticle-mediated delivery of therapeutics and biological agents has been documented in the literature and a recent example is the COVID-19 vaccines (liposomal formulations). Over 100 nanotechnology-based formulations are in clinical use for various indications. However, there are still challenges associated with unique imaging, tracing, and theranostic techniques for the areas of the body that are more difficult to reach. In this regard, we seek novel formulations that are well-suited to drug/contrast/biomacromolecular delivery and their potential modifications and functionalization for targeted accumulation and therapeutic benefits. Image-guided therapeutic delivery is a new concept that combines the effect of therapy and visibility aspects into one single system to overcome the conventional limitations that exist in nanotechnology. These targeted nanoformulations with a variety of medical imaging tracking capability approaches can develop “see and treat” technologies for site-specific treatment in a minimally invasive way, for effective management of various diseases.

In this Special Issue, original research articles and reviews are welcome. Research areas may include, but are not limited to, recent advances in novel nanoparticle constructs, drug-delivery, imaging, and theranostic applications. This Special Issue also covers smart biocompatible/biodegradable theranostics, metal-based nanoformulations, medical imaging tracking modalities, and imaging applied in the drug-delivery field. Moreover, we also encourage research on the aspects of applied characterization, toxicity, and site/disease-specific or multi-modal contrast agents.

Dr. Murali Mohan Yallapu
Dr. Nicolas Anton
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • theranostics/nanotheranostics
  • multimodal imaging
  • combined therapies
  • tumor targeting
  • metallic nanoparticles
  • multi-component nanoparticles
  • medical imaging
  • drug delivery
  • nano imaging agents

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Published Papers (2 papers)

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Research

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18 pages, 4662 KiB  
Article
Modulating the Effect of β-Sitosterol Conjugated with Magnetic Nanocarriers to Inhibit EGFR and Met Receptor Cross Talk
by Shanmuga Sundari Ilangovan, Biswanath Mahanty, Venkatesan Perumal and Shampa Sen
Pharmaceutics 2023, 15(8), 2158; https://doi.org/10.3390/pharmaceutics15082158 - 19 Aug 2023
Cited by 1 | Viewed by 1595
Abstract
The cross-talk between the EGFR (Epidermal Growth Factor Receptor) and MET (Hepatocyte Growth Factor Receptor) poses a significant challenge in the field of molecular signaling. Their intricate interplay leads to dysregulation and contributes to cancer progression and therapeutic resistance. β-Sitosterol (BS), a plant [...] Read more.
The cross-talk between the EGFR (Epidermal Growth Factor Receptor) and MET (Hepatocyte Growth Factor Receptor) poses a significant challenge in the field of molecular signaling. Their intricate interplay leads to dysregulation and contributes to cancer progression and therapeutic resistance. β-Sitosterol (BS), a plant sterol with promising anticancer properties, shows increased research on its potential as a chemopreventive agent. However, significant modifications are required to deliver BS in cancer cells due to its lower efficacy. The present work aims to design a carrier-mediated delivery system specifically targeting cancer cells with EGFR and MET receptor cross-talk. Surface modification of BS was performed with superparamagnetic iron oxide nanoparticles (SPIONs), polyethylene glycol (PEG), and poly(N-isopropylacrylamide) (PNIPAM) to enhance the delivery of BS at the target site. BS was conjugated with SPIONs (BS-S), PNIPAM (BS-SP), PEG, and PNIPAM (BS-SPP) polymers, respectively, and the conjugated complexes were characterized. Results showed an increase in size, stability, and monodispersity in the following order, BS-S, BS-SP, and BS-SPP. The drug encapsulation efficiency was observed to be highest in BS-SPP (82.5%), compared to BS-S (61%) and BS-SP (74.9%). Sustained drug release was achieved in both BS-SP (82.6%) and BS-SPP (83%). The IC 50 value of BS, BS-S, BS-SP, and BS-SPP towards MCF 7 was 242 µg/mL,197 µg/mL, 168 µg/mL, and 149 µg/mL, HEPG2 was 274 µg/mL, 261 µg/mL, 233 µg/mL and 207 µg/mL and NCIH 460 was 191 µg/mL, 185 µg/mL, 175 and 164 µg/mL, indicating highest inhibition towards NCIH 460 cells. Our results conclude that β-sitosterol conjugated with SPION, PEG, and PNIPAM could be a potential targeted therapy in inhibiting EGFR and MET receptor-expressing cancer cells. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Image-Guided and Targeted Theranostic Platforms)
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Review

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47 pages, 8603 KiB  
Review
“Bioinspired” Membrane-Coated Nanosystems in Cancer Theranostics: A Comprehensive Review
by Nimeet Desai, Dhwani Rana, Shreya Pande, Sagar Salave, Jyotsnendu Giri, Derajram Benival and Nagavendra Kommineni
Pharmaceutics 2023, 15(6), 1677; https://doi.org/10.3390/pharmaceutics15061677 - 8 Jun 2023
Cited by 17 | Viewed by 3207
Abstract
Achieving precise cancer theranostics necessitates the rational design of smart nanosystems that ensure high biological safety and minimize non-specific interactions with normal tissues. In this regard, “bioinspired” membrane-coated nanosystems have emerged as a promising approach, providing a versatile platform for the development of [...] Read more.
Achieving precise cancer theranostics necessitates the rational design of smart nanosystems that ensure high biological safety and minimize non-specific interactions with normal tissues. In this regard, “bioinspired” membrane-coated nanosystems have emerged as a promising approach, providing a versatile platform for the development of next-generation smart nanosystems. This review article presents an in-depth investigation into the potential of these nanosystems for targeted cancer theranostics, encompassing key aspects such as cell membrane sources, isolation techniques, nanoparticle core selection, approaches for coating nanoparticle cores with the cell membrane, and characterization methods. Moreover, this review underscores strategies employed to enhance the multi-functionality of these nanosystems, including lipid insertion, membrane hybridization, metabolic engineering, and genetic modification. Additionally, the applications of these bioinspired nanosystems in cancer diagnosis and therapeutics are discussed, along with the recent advances in this field. Through a comprehensive exploration of membrane-coated nanosystems, this review provides valuable insights into their potential for precise cancer theranostics. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Image-Guided and Targeted Theranostic Platforms)
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