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Processes
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Advances in Cell Death Pathways
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Advances in Cell Death Pathways

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Processes and Systems".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 6272

Special Issue Editor

Dr. Magdalena Skonieczna

E-Mail Website
Guest Editor
1 Department of Systems Biology and Engineering, Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, 44-100 Gliwice, Poland; 2 Biotechnology Centre, Silesian University of Technology, 44-100 Gliwice, Poland.
Interests: cell biology; cancer cells; cell signaling; oxidative stress; cytotoxicity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Human health is influenced by many external factors, ranging from cellular dysfunction such as oxidative stress. The intracellular redox potential influences cellular function, and its deregulation is associated with cell death, resulting in the development of various diseases. Reactive oxygen species (ROS) are free-radical or non-radical oxygen species that are characterized by high reactivity. In healthy cells, ROS occur at the physiological level because they are involved in many cellular processes, such as hormone secretion, drug removal, and detoxification or stimulation of the immune system. The overproduction of ROS can lead to oxidative stress, which can result in permanent changes in the cells, leading to the loss of protein function, which in turn can cause disease. Irreversible changes in the cell can severely disrupt entire metabolic pathways, leading to various types of cell death, such as apoptosis, ferroptosis, and necrosis.

Dr. Magdalena Skonieczna
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cellular death
  • oxidative stress
  • apoptosis
  • necrosis, ferroptosis

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Published Papers (2 papers)

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Research

16 pages, 8715 KiB  
Article
Effect of Static and Dynamic Stretching on Corneal Fibroblast Cell
by Zhi-Xuan Dai, Po-Jen Shih, Jia-Yush Yen and I-Jong Wang
Processes 2022, 10(3), 605; https://doi.org/10.3390/pr10030605 - 20 Mar 2022
Cited by 4 | Viewed by 2946
Abstract
A strain gradient was created by punching a hole in the center of a stretched elastic polydimethylsiloxane membrane to determine the effect of different strains on cultured human keratocytes (HK). In this study, two stretching methods were used: continuous stretching and cyclic stretching. [...] Read more.
A strain gradient was created by punching a hole in the center of a stretched elastic polydimethylsiloxane membrane to determine the effect of different strains on cultured human keratocytes (HK). In this study, two stretching methods were used: continuous stretching and cyclic stretching. Continuous stretching is relatively static, while acyclic stretching is relatively dynamic. These methods, respectively, represented the effects of high intraocular pressure and rubbing of the eyes on corneal cells. Image processing codes were developed to observe the effects of stress concentration, shear stress, continuous stretching, and cyclic stretching on HKs. The results demonstrate that stretching and shear stress are not conducive to the proliferation of corneal cells and instead cause cell death. A 10% strain had greater inhibitory effects than a 3% strain on cell proliferation. Cell survival rates for continuous stretching (static) were higher than those for cyclic stretching (dynamic). The stretching experiment revealed that cyclic stretching has a greater inhibitory effect on the growth and proliferation of corneal cells than continuous stretching. Accordingly, it shows that cyclic loading is more harmful than high intraocular pressure (static loading) to corneal cells. Full article
(This article belongs to the Special Issue Advances in Cell Death Pathways)
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17 pages, 2935 KiB  
Article
Flavonoids Induce Migration Arrest and Apoptosis in Detroit 562 Oropharynx Squamous Cell Carcinoma Cells
by Arkadiusz Dziedzic, Robert Kubina, Robert D. Wojtyczka, Marta Tanasiewicz, Elena Maria Varoni and Marcello Iriti
Processes 2021, 9(3), 426; https://doi.org/10.3390/pr9030426 - 27 Feb 2021
Cited by 5 | Viewed by 2410
Abstract
Despite advances in the treatment of head and neck squamous cell carcinoma (HNSCC), the morbidity remains at a high level due to the resistance of SCC cells to chemotherapeutics. This study aimed to determine and compare the magnitude of the flavonoids’ effectiveness in [...] Read more.
Despite advances in the treatment of head and neck squamous cell carcinoma (HNSCC), the morbidity remains at a high level due to the resistance of SCC cells to chemotherapeutics. This study aimed to determine and compare the magnitude of the flavonoids’ effectiveness in activating apoptosis and migration arrest in HNSCC cells in vitro. Methods: Head and neck SCC cells of the Detroit 562 line were exposed to a range of concentrations (5–100 μM) of quercetin (Que), hesperidin (Hes) and rutin (Rut) for 24 and 48 h. The SCC cell viability and migration rate were investigated using cytotoxicity and migration inhibition assays. Muse Cell Analyzer flow cytometry was utilized to quantitatively assess the apoptosis rate of Detroit 562 cells exposed to Que, Hes and Rut. The morphology of the SCC cells was evaluated via hematoxylin-eosin staining. Results: The viability diminishment of the Detroit 562-line cells treated with Que, Hes and Rut for 48 h revealed a significant dose-dependent trend, relatively equal for three substances, whereas the most noticeable cytotoxic effect observed for Hes. Exposure to Hes and Rut exhibited a dose-dependent increased proportion of apoptotic SCC cells, at either necrosis or late apoptosis stage. Detroit 562 SCC migration rate and cells motility were halted for the 100 µM dose of Hes and Que. The comparative results elucidated that Hesperidin and Quercetin achieved a more potent reduction of Detroit 562 migration at 24 h. Conclusions: Hesperidin, rutin and quercetin are capable of inducing apoptosis and migration arrest in the Detroit 562 cell line to various extents, resulting in proapoptotic attenuating effects at different magnitudes. Full article
(This article belongs to the Special Issue Advances in Cell Death Pathways)
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