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Sensors and Actuators in Microfluidic Devices for Analysis
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Sensors and Actuators in Microfluidic Devices for Analysis

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 9014

Special Issue Editors

Dr. Fernando Benito López

E-Mail Website
Guest Editor
Microfluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip (AMMa-LOAC) Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain
Interests: microfluidics; point-of-care devices; lab-on-a-chip; sensors; smart materials; wearable devices
Special Issues, Collections and Topics in MDPI journals
Dr. Janire Saez-Castaño

E-Mail Website
Guest Editor
1. Microfluidics Cluster UPV/EHU, BIOMICs microfluidics Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Leioa, Spain
2. Basque Foundation of Science, IKERBASQUE, Bilbao, Spain
Interests: smart materials into microfluidic devices, fluidic control, sensing, “organ-on-a-chip”, bioelectronics, cancer research
Special Issues, Collections and Topics in MDPI journals
Dr. Larisa Florea

E-Mail Website
Guest Editor
School of Chemistry, Trinity College Dublin, College Green, Dublin 2, Ireland
Interests: development of new stimuli-responsive polymers; 3D fabrication technologies; microfabrication of polymeric actuators and sensors; development of smart microvehicles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidics continues growing exponentially in science, allowing analytical measurements to be performed faster and at lower costs than conventional analysis. All this is possible thanks to the miniaturisation and parallelisation of the whole analytical process. The final outcome of this is a highly efficient, high throughput, accurate and controllable analysis, most of the times, at the point of need and without the need for specialised personnel. 

The critical need for a large variety of high performance sensing components such as integrated micro-sensors, smart materials, optical fibers, as well as fluid control and transport components such as mixers, actuators, separators, valves and pumps is leading researchers to investigate the development of these miniaturised building blocks and promoting their integrability in a microfluidic device format.

Moreover, the industrial interest of microfluidics and its high commercialisation perspective need to be considered, which are adding value to this field and opening up new research avenues with a marked applicability.

We are soliciting original submissions that contribute to novel aspects in the microfluidics and lab-on-a-chip fields, taking a holistic approach of the microfluidic device, from the sensor (material, integration, performance, detection, etc.) and the microfluidic components (valves, pumps, microfluidic design, etc.) to commercialisation of the device and its societal perspective. The list of possible topics includes:

- Microfluidic device fabrication;

- Microfluidic component characterisation;

- Microfluidic components integration;

- Microfluidic sensors: physical and chemical sensors;

- New materials for sensing and actuation at the microscale;

- Actuators in microfluidics as components to improve sensing devices;

- Industrial applications of microfluidic sensors;

- Commercialisation of microfluidics.

Dr. Fernando Benito-Lopez
Dr. Janire Saez-Castaño
Dr. Larisa Florea
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Microfluidics
  • lab-on-a-chip
  • sensors, actuators, materials
  • commercialisation of microfluidics

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Published Papers (3 papers)

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Research

16 pages, 4425 KiB  
Article
Vision-Based Performance Analysis of an Active Microfluidic Droplet Generation System Using Droplet Images
by Amith Mudugamuwa, Samith Hettiarachchi, Gehan Melroy, Shanuka Dodampegama, Menaka Konara, Uditha Roshan, Ranjith Amarasinghe, Dumith Jayathilaka and Peihong Wang
Sensors 2022, 22(18), 6900; https://doi.org/10.3390/s22186900 - 13 Sep 2022
Cited by 5 | Viewed by 2618
Abstract
This paper discusses an active droplet generation system, and the presented droplet generator successfully performs droplet generation using two fluid phases: continuous phase fluid and dispersed phase fluid. The performance of an active droplet generation system is analysed based on the droplet morphology [...] Read more.
This paper discusses an active droplet generation system, and the presented droplet generator successfully performs droplet generation using two fluid phases: continuous phase fluid and dispersed phase fluid. The performance of an active droplet generation system is analysed based on the droplet morphology using vision sensing and digital image processing. The proposed system in the study includes a droplet generator, camera module with image pre-processing and identification algorithm, and controller and control algorithm with a workstation computer. The overall system is able to control, sense, and analyse the generation of droplets. The main controller consists of a microcontroller, motor controller, voltage regulator, and power supply. Among the morphological features of droplets, the diameter is extracted from the images to observe the system performance. The MATLAB-based image processing algorithm consists of image acquisition, image enhancement, droplet identification, feature extraction, and analysis. RGB band filtering, thresholding, and opening are used in image pre-processing. After the image enhancement, droplet identification is performed by tracing the boundary of the droplets. The average droplet diameter varied from ~3.05 mm to ~4.04 mm in the experiments, and the average droplet diameter decrement presented a relationship of a second-order polynomial with the droplet generation time. Full article
(This article belongs to the Special Issue Sensors and Actuators in Microfluidic Devices for Analysis)
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10 pages, 1262 KiB  
Communication
A Three-Reagent “Green” Paper-Based Analytical Device for Solid-Phase Spectrometric and Colorimetric Determination of Dihydroquercetin
by Vladimir V. Apyari, Aleksei A. Furletov, Vyacheslav I. Kalinin, Stanislava G. Dmitrienko and Yury A. Zolotov
Sensors 2022, 22(8), 2893; https://doi.org/10.3390/s22082893 - 9 Apr 2022
Cited by 5 | Viewed by 2275
Abstract
Microfluidic paper-based analytical devices (µPADs) represent one of the promising green analytical strategies for low-cost and simple determination of various analytes. The actual task is the development of such devices for quantitation of antioxidants, e.g., flavonoids. In this paper, possibilities of a novel [...] Read more.
Microfluidic paper-based analytical devices (µPADs) represent one of the promising green analytical strategies for low-cost and simple determination of various analytes. The actual task is the development of such devices for quantitation of antioxidants, e.g., flavonoids. In this paper, possibilities of a novel three-reagent µPAD including silver nitrate, 4-nitrophenyldiazonium tetrafluoroborate, and iron(III) chloride as reagents are assessed with respect to the determination of dihydroquercetin. It is shown that all the three reagents produce different colorimetric responses that can be detected by a mini-spectrophotometer–monitor calibrator or by a smartphone. The method is applicable to direct measuring high contents of dihydroquercetin (the linearity range is 0.026–1 mg mL−1, and the limit of detection is 7.7 µg mL−1), which is favorable for many dietary supplements. The analysis of a food supplement was possible with the relative standard deviations of 9–26%, which is satisfactory for quantitative and semiquantitative determinations. It was found that plotting a calibration graph in 3D space of the three reagents’ responses allows us to distinguish dihydroquercetin from its close structural analogue, quercetin. Full article
(This article belongs to the Special Issue Sensors and Actuators in Microfluidic Devices for Analysis)
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15 pages, 7113 KiB  
Article
Manufacturing of Microfluidic Devices with Interchangeable Commercial Fiber Optic Sensors
by Krystian L. Wlodarczyk, William N. MacPherson, Duncan P. Hand and M. Mercedes Maroto-Valer
Sensors 2021, 21(22), 7493; https://doi.org/10.3390/s21227493 - 11 Nov 2021
Cited by 2 | Viewed by 3241
Abstract
In situ measurements are highly desirable in many microfluidic applications because they enable real-time, local monitoring of physical and chemical parameters, providing valuable insight into microscopic events and processes that occur in microfluidic devices. Unfortunately, the manufacturing of microfluidic devices with integrated sensors [...] Read more.
In situ measurements are highly desirable in many microfluidic applications because they enable real-time, local monitoring of physical and chemical parameters, providing valuable insight into microscopic events and processes that occur in microfluidic devices. Unfortunately, the manufacturing of microfluidic devices with integrated sensors can be time-consuming, expensive, and “know-how” demanding. In this article, we describe an easy-to-implement method developed to integrate various “off-the-shelf” fiber optic sensors within microfluidic devices. To demonstrate this, we used commercial pH and pressure sensors (“pH SensorPlugs” and “FOP-MIV”, respectively), which were “reversibly” attached to a glass microfluidic device using custom 3D-printed connectors. The microfluidic device, which serves here as a demonstrator, incorporates a uniform porous structure and was manufactured using a picosecond pulsed laser. The sensors were attached to the inlet and outlet channels of the microfluidic pattern to perform simple experiments, the aim of which was to evaluate the performance of both the connectors and the sensors in a practical microfluidic environment. The bespoke connectors ensured robust and watertight connection, allowing the sensors to be safely disconnected if necessary, without damaging the microfluidic device. The pH SensorPlugs were tested with a pH 7.01 buffer solution. They measured the correct pH values with an accuracy of ±0.05 pH once sufficient contact between the injected fluid and the measuring element (optode) was established. In turn, the FOP-MIV sensors were used to measure local pressure in the inlet and outlet channels during injection and the steady flow of deionized water at different rates. These sensors were calibrated up to 140 mbar and provided pressure measurements with an uncertainty that was less than ±1.5 mbar. Readouts at a rate of 4 Hz allowed us to observe dynamic pressure changes in the device during the displacement of air by water. In the case of steady flow of water, the pressure difference between the two measuring points increased linearly with increasing flow rate, complying with Darcy’s law for incompressible fluids. These data can be used to determine the permeability of the porous structure within the device. Full article
(This article belongs to the Special Issue Sensors and Actuators in Microfluidic Devices for Analysis)
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