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Toxics
Special Issues
Ototoxic Chemical Exposures and Public Health
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Ototoxic Chemical Exposures and Public Health

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Human Toxicology and Epidemiology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 4115

Special Issue Editors

Dr. Thais C. Morata

E-Mail Website
Guest Editor
National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA
Interests: combined exposures; effects of noise; prevention; systematic reviews
Special Issues, Collections and Topics in MDPI journals
Dr. Gregory Zarus

E-Mail Website
Guest Editor
Agency for Toxic Substances and Disease Registry (ATSDR), Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Interests: exposure science; chemical monitoring; modeling; omics; genotoxicity and ototoxicity
Dr. Krystin Carlson

E-Mail Website
Guest Editor
Synergy America, Inc., Duluth, GA 30097, USA
Interests: translational toxicology; public health guidelines; hearing conservation

Special Issue Information

Dear Colleagues,

The 2021 World Report on Hearing by the World Health Organization identified exposure to ototoxic chemicals as one of the preventable causative factors to hearing disorders across one’s life course.  The report also included exposure to these agents among the risk factors that need to be addressed to limit the burden of the condition across the world.  Detection, diagnosis and management of ototoxicity continue to be a challenge worldwide. We encourage submissions to this Special Issue concerning the mechanism of action of ototoxic chemicals, ways in which auditory and vestibular damage manifests in an individual, approaches to the early detection of auditory and vestibular disorders, diagnosis, treatment, and prevention of auditory disorders caused by environmental or occupational exposure to ototoxic chemicals.

Dr. Thais C. Morata
Dr. Gregory Zarus
Dr. Krystin Carlson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • early detection
  • diagnosis
  • treatment
  • prevention
  • occupational exposures
  • hearing
  • vestibular/balance
  • tinnitus/ringing

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Published Papers (2 papers)

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Research

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10 pages, 267 KiB  
Article
Hearing Loss and Urinary trans,trans-Muconic Acid (t,t-MA) in 6- to 19-Year-Old Participants of NHANES 2017–March 2020
by Rae T. Benedict, Franco Scinicariello, Henry G. Abadin, Gregory M. Zarus and Roberta Attanasio
Toxics 2024, 12(3), 191; https://doi.org/10.3390/toxics12030191 - 29 Feb 2024
Cited by 1 | Viewed by 1617
Abstract
Hearing loss (HL) is associated with poorer language development and school performance. Ototoxic substances such as metals and solvents, including benzene, are a risk factor associated with HL. This study examines potential associations between the benzene metabolite trans,trans-muconic acid ( [...] Read more.
Hearing loss (HL) is associated with poorer language development and school performance. Ototoxic substances such as metals and solvents, including benzene, are a risk factor associated with HL. This study examines potential associations between the benzene metabolite trans,trans-muconic acid (t,t-MA) and HL in youth of the National Health and Nutrition Examination Survey (NHANES). Logistic regression calculated adjusted odds ratio (aOR) associations between HL and urinary t,t-MA quartiles, natural-log transformed, and doubled urinary t,t-MA. Hearing threshold pure-tone average (PTA) at speech frequencies (SF) 0.5, 1, 2, and 4 kHz and high frequencies (HF) 3, 4, and 6 kHz were analyzed for slight HL (PTA > 15 dB) and mild HL (PTA > 20 dB). Urinary t,t-MA was statistically significantly associated with both slight SF and HF HL. For each doubling of t,t-MA there were increased odds of having slight SFHL (aOR = 1.42; 95% CI: 1.05, 1.92), slight HFHL (aOR = 1.31; 95% CI: 1.03, 1.66), mild SFHL (aOR = 1.60; 95% CI: 1.10, 2.32), and mild HFHL (aOR = 1.45; 95% CI: 1.03, 2.04). To our knowledge, this is the first population-based report of an association between SFHL, HFHL, and the benzene metabolite t,t-MA in youth 6 to 19 years old. Full article
(This article belongs to the Special Issue Ototoxic Chemical Exposures and Public Health)

Review

Jump to: Research

26 pages, 686 KiB  
Review
Which Environmental Pollutants Are Toxic to Our Ears?—Evidence of the Ototoxicity of Common Substances
by Gregory M. Zarus, Patricia Ruiz, Rae Benedict, Stephan Brenner, Krystin Carlson, Layna Jeong and Thais C. Morata
Toxics 2024, 12(9), 650; https://doi.org/10.3390/toxics12090650 - 4 Sep 2024
Viewed by 1695
Abstract
Ototoxicity refers to the adverse effects of substances on auditory or vestibular functions. This study examines the evidence of ototoxicity’s association with exposure to common environmental pollutants, as documented in toxicological profiles by the Agency for Toxic Substances and Disease Registry. Our aim [...] Read more.
Ototoxicity refers to the adverse effects of substances on auditory or vestibular functions. This study examines the evidence of ototoxicity’s association with exposure to common environmental pollutants, as documented in toxicological profiles by the Agency for Toxic Substances and Disease Registry. Our aim was to evaluate whether the evidence supports modifying the charting of ototoxic effects in the summary tables of these toxicological profiles and providing a guide for scientists to access these data. Health outcomes of interest included hearing loss, vestibular effects, cochlear lesions, tonal alterations, cellular damage, and ototoxicity-related outcomes (neurological, nephrotoxic, hepatic, and developmental effects). We obtained ototoxicity information for 62 substances. Hearing-related effects were reported, along with neurological effects. Overall, 26 profiles reported strong evidence of ototoxicity, including 13 substances previously designated as ototoxic by other health and safety agencies. Commonly studied outcomes included hearing loss, damage to ear anatomy, and auditory dysfunction. Vestibular dysfunction and tinnitus are rarely studied. Our findings highlight the lack of conclusive evidence of ototoxic properties for many substances, especially for pesticides and herbicides. This review supports charting the evidence of ototoxicity separately in toxicological profiles’ summary tables. Improving the communication of ototoxicity-related health effects might impact their recognition and prompt further research. A stronger evidence base could support improved prevention efforts in terms of serious health outcomes. Full article
(This article belongs to the Special Issue Ototoxic Chemical Exposures and Public Health)
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