Cadmium Pollution and Occupational Exposure

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Human Toxicology and Epidemiology".

Deadline for manuscript submissions: 21 February 2025 | Viewed by 1833

Special Issue Editor


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Guest Editor
Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
Interests: environmental medicine; occupational health; cadmium; epidemiplogy; exposure
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Special Issue Information

Dear Colleagues,

The renal and bone effects of cadmium exposure are well known, and there are also concerns about carcinogeneniety and life prognosis. The main sources of exposure to cadmium are in occupations, e.g., battery manufacturing, alloys, and plating industries, and in the general environment, e.g., food and smoking. The health effects of cadmium exposure are a global concern and remain an issue for many researchers.

This Special Issue is open to any subject area related to environmental and occupational exposure and the health effects of cadmium.

Prof. Dr. Yasushi Suwazono
Guest Editor

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Keywords

  • cadmium
  • environmental exposure
  • general population
  • occupational medicine
  • renal effect
  • mortality

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Published Papers (1 paper)

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Research

9 pages, 440 KiB  
Article
Benchmark Dose of Urinary Cadmium for Assessing Renal Tubular and Glomerular Function in a Cadmium-Polluted Area of Japan
by Takuya Hayashi, Kazuhiro Nogawa, Yuuka Watanabe, Teruhiko Kido, Masaru Sakurai, Hideaki Nakagawa and Yasushi Suwazono
Toxics 2024, 12(12), 836; https://doi.org/10.3390/toxics12120836 - 21 Nov 2024
Viewed by 1522
Abstract
The aim of the present study was to apply an updated benchmark dose (BMD) approach to estimate reference urinary cadmium (U-Cd) for renal tubular and glomerular effects. This cross-sectional survey was conducted 30 years ago in 30 men and 44 women living in [...] Read more.
The aim of the present study was to apply an updated benchmark dose (BMD) approach to estimate reference urinary cadmium (U-Cd) for renal tubular and glomerular effects. This cross-sectional survey was conducted 30 years ago in 30 men and 44 women living in a Cd-polluted area and in 18 men and 18 women living in a non-polluted area. We applied an updated hybrid approach to estimate the BMDs and 95% lower confidence limits (BMDLs) of U-Cd for creatinine (Cr) clearance (CrCl), estimated glomerular filtration rate (eGFR), β2-microglobulin (β2-MG), and β2-MG tubular reabsorption (%TRβ2-MG). Using a benchmark response (BMR) of 5%, we estimated the BMDLs of U-Cd for adverse renal effect markers to be 2.9 (eGFR), 1.8 (β2-MG), 1.8 (%TRβ2-MG < 95%), and 3.6 μg/g Cr (%TRβ2-MG < 90%) in men, and 3.5 (CrCl), 2.5 (β2-MG), 2.6 (%TRβ2-MG < 95%), and 3.9 μg/g Cr (%TRβ2-MG < 90%) in women. The obtained BMDLs for tubular effects were 1.8–3.6 µg/g Cr and for glomerular effects were 2.9–3.5 µg/g Cr; these are not very high compared to the exposure levels in the general population. The BMDLs calculated in this study provide important information for measures regarding protecting general inhabitants or workers from the adverse health effects of Cd exposure. Full article
(This article belongs to the Special Issue Cadmium Pollution and Occupational Exposure)
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