Extracellular Vesicles as a Platform for Vaccines
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: closed (26 August 2024) | Viewed by 4571
Special Issue Editors
Interests: extracellular vesicles; vaccine; cancer; mRNA; microRNAs; immune responses; T cells; dendritic cells; major histocompatibility complex (MHC); deep learning; virus
Special Issues, Collections and Topics in MDPI journals
Interests: small RNA; nuclear protein transport; cell death mechanism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Extracellular vesicles (EVs), including exosomes, are approximately 50 to 150 nm in diameter, where their surface contains lipids and proteins derived from cell membranes, and the interior includes nucleic acids, such as microRNAs, mRNAs, and DNA, derived from intracellular substances. To date, numerous approaches are being investigated, including novel therapeutics using EVs. In addition, EV–virus interactions have potential applications in antiviral drug and vaccine developments. EVs are produced by virus-infected cells and play an important role in mediating the communication between uninfected and infected cells. Thus, viruses regulate the production and composition of EVs and can facilitate the infection, spread, and cell-to-cell spread utilizing the EVs’ secretion, formation, and release pathways. Furthermore, the technological development of dendritic cell vaccines that contribute to personalized medicine targeting neoantigens generated by gene mutations in cancer cells is attracting a considerable amount of attention. Dendritic cells (DCs) with different cytokines present different phenotypes related to their antigen-presenting ability. Furthermore, similar differences have been observed in the released EVs, suggesting that there may be differences in the antigen-presenting ability of the EVs themselves. The selection of functionally superior EVs is necessary for the production of DC vaccines by a novel nucleic acid transfer method using cancer antigen-derived mRNA.
This Special Issue aims to highlight the latest research on the role, biogenesis, and structure of EVs in vaccines. The topics that we intend to cover include (but are not limited to) the following areas:
- EVs-based DCs vaccine;
- Antigen presentation through EVs;
- Regulation of immune responses through EVs.
We invite submissions of both research and review articles and look forward to receiving your contributions.
Dr. Yasunari Matsuzaka
Dr. Ryu Yashiro
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antigen presentation
- exosomes derived from dendritic cells
- extracellular vesicles
- immunotherapeutic strategies
- MHC
- T-cell responses
- vaccine
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
