Biotechnological Applications of Phage and Phage-Derived Proteins 2025
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Bacterial Viruses".
Deadline for manuscript submissions: 17 March 2025 | Viewed by 2114
Special Issue Editor
Interests: bacteriophages; genetic and protein engineering; protein functional analysis; biotechnology; pharmaceutical
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bacteriophages, the viruses of bacteria, are recognized for their potential as antimicrobial agents since their discovery, roughly a century ago, but the early inadequately controlled trials, the poor knowledge on their biology and the discovery of antibiotics has slowed phage research. In recent years, the increasing problem of multidrug-resistant bacteria has renewed and heightened interest in the use of phages as antimicrobial agents.
The recent progress in sequencing technologies, DNA manipulation and synthetic biology has equipped scientists with the necessary tools to disclose and use the powerful armamentarium of proteins that phages possess to parasite bacteria. These proteins can be used ex-phage (isolated from the phage particle) or modified/added to design phages with improved and superior characteristics and functionalities which enabled the development of new powerful applications of phages and their proteins not only in therapeutics (as new source of antimicrobials, drug delivery systems and vaccines) but also in diagnostics and materials science (for the assembly of new materials). As new phage proteins are being discovered, new valuable biotechnological applications are envisaged.
With the wide array of possibilities offered by genetic engineering and its attracting intense interest coupled with the high potential of phages, this Special Issue will focus on new biotechnological applications of phage and their derived proteins, as well on the new strategies to obtain them. Bacteriophage therapy through the use of wild type phages (without any genetic modification) is out of focus of this special issue.
Dr. Silvio Santos
Guest Editor
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Keywords
- bacteriophage
- biotechnological applications
- genetic engineering
- antimicrobials
- diagnostic
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