Human Hepatitis Viruses and Their Animal Homologues

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1519

Special Issue Editors

Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA
Interests: emerging/re-emerging viruses; zoonotic viral infections; viral hepatitis and gastroenteritis; molecular epidemiology; diagnostics; mutagenesis; public health
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650023, China
Interests: bat and rodent virus discovery; virus isolation; virus–host interaction; viral pathogenesis; viral ecology; emerging infectious diseases; attenuated and inactivated vaccines
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Human hepatitis A to E viruses continue to present significant threats to public health. Recent advancements in high-throughput sequencing techniques in metagenomics, coupled with a burgeoning interest in the viromes of small mammals, have led to the discovery of homologues of human hepatitis viruses in various animal species beyond primates. However, the molecular biology and pathogenicity of these novel viruses remain largely unexplored, and the zoonotic potential of these homologues, particularly hepatitis E virus-related viruses, requires further investigation. Nevertheless, the identification of genetically divergent hepatitis viruses in diverse animal species provides valuable insights into the origins and evolution of human hepatitis viruses. Moreover, the discovery of these homologues offers a promising opportunity to establish animal models for studying the mechanistic pathogenesis of human hepatitis viruses. This Special Issue aims at encompassing a broad spectrum of topics related to the human hepatitis viruses and their animal counterparts.

Dr. Bo Wang
Prof. Dr. Xinglou Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hepatitis viruses
  • animal virome
  • genetic diversity
  • genomic organization
  • ecology and evolution
  • molecular biology
  • molecular epidemiology
  • zoonotic potential

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 3668 KiB  
Article
Identification and Genomic Characterization of Two Novel Hepatoviruses in Shrews from Yunnan Province, China
by Yi Tang, Kai Zhao, Hong-Min Yin, Li-Ping Yang, Yue-Chun Wu, Feng-Yi Li, Ze Yang, Hui-Xuan Lu, Bo Wang, Yin Yang, Yun-Zhi Zhang and Xing-Lou Yang
Viruses 2024, 16(6), 969; https://doi.org/10.3390/v16060969 - 17 Jun 2024
Viewed by 1147
Abstract
Hepatitis A virus (HAV), a member of the genus Hepatovirus (Picornaviridae HepV), remains a significant viral pathogen, frequently causing enterically transmitted hepatitis worldwide. In this study, we conducted an epidemiological survey of HepVs carried by small terrestrial mammals in the wild in [...] Read more.
Hepatitis A virus (HAV), a member of the genus Hepatovirus (Picornaviridae HepV), remains a significant viral pathogen, frequently causing enterically transmitted hepatitis worldwide. In this study, we conducted an epidemiological survey of HepVs carried by small terrestrial mammals in the wild in Yunnan Province, China. Utilizing HepV-specific broad-spectrum RT-PCR, next-generation sequencing (NGS), and QNome nanopore sequencing (QNS) techniques, we identified and characterized two novel HepVs provisionally named EpMa-HAV and EpLe-HAV, discovered in the long-tailed mountain shrew (Episoriculus macrurus) and long-tailed brown-toothed shrew (Episoriculus leucops), respectively. Our sequence and phylogenetic analyses of EpMa-HAV and EpLe-HAV indicated that they belong to the species Hepatovirus I (HepV-I) clade II, also known as the Chinese shrew HepV clade. Notably, the codon usage bias pattern of novel shrew HepVs is consistent with that of previously identified Chinese shrew HepV. Furthermore, our structural analysis demonstrated that shrew HepVs differ from other mammalian HepVs in RNA secondary structure and exhibit variances in key protein sites. Overall, the discovery of two novel HepVs in shrews expands the host range of HepV and underscores the existence of genetically diverse animal homologs of human HAV within the genus HepV. Full article
(This article belongs to the Special Issue Human Hepatitis Viruses and Their Animal Homologues)
Show Figures

Figure 1

Back to TopTop