Bacteriophage Lytic Proteins
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Bacterial Viruses".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 3393
Special Issue Editor
Interests: mechanisms of bacteriophage-induced lysis; mycobacteriophages; activity of lytic proteins; bacteriophage engineering; development of bacteriophage-based products for therapeutic purposes
Special Issue Information
Dear Colleagues,
The global problem of bacterial resistance to antibiotics has increased the focus on bacteriophage research, particularly due to the potential of these viruses to lyse bacterial pathogens. Phage-induced lysis results from the synthesis of lytic proteins that compromise each barrier of the bacterial cell envelope. These proteins are designed to target bacteriophages’ specific hosts, being structurally diverse and having different activities. Knowledge of their characteristics and understanding their modes of action are important contributions to the development of new tools to kill bacteria and fight multidrug resistance.
This Special Issue, entitled “Bacteriophage Lytic Proteins”, aims to present recent research on any aspect of lysis protein activity, such as holins, endolysins, spanins, and the specific proteins of actinobacteriophages targeting the mycolil layers. Some of its focal points include, but are not limited to, the following:
- Delivery of phage lytic proteins to their targets;
- Understanding endolysin activation and contribution of their functional domains to lysis;
- Mechanisms of phage-induced lysis;
- Bioengineering and applications of phage-derived lytic proteins.
Dr. Madalena Pimentel
Guest Editor
Manuscript Submission Information
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Keywords
- bacteriophage
- phage lysis
- holins
- endolysins
- spanins
- mycolil esterases
- antimicrobials
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