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Viruses
Special Issues
Enteric Viruses, Bacteria, and the Virome in Health and Disease
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Enteric Viruses, Bacteria, and the Virome in Health and Disease

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 1696

Special Issue Editor

Dr. Melissa K. Jones

E-Mail Website
Guest Editor
Microbiology and Cell Science Department, University of Florida, Gainesville, FL, USA
Interests: enteric viral infection; virus-bacterial interactions; bacterial extracellular vesicles; noroviruses; OMVs; innate immune responses; commensal bacteria

Special Issue Information

Dear Colleagues,

Acute and chronic intestinal diseases are a leading cause of illness worldwide. While pathogenic bacteria and viruses are linked to many of these diseases, it is now appreciated that commensal microbes can also modulate host responses and influence disease outcomes. The interaction between viruses and bacteria in the lung has been extensively studied; however, parallel interactions between bacteria and viruses in the intestinal tract remain under-explored. Moreover, the role of the virome in regulating gut homeostasis and influencing acute and chronic diseases in the gut is also under-studied. This Special Issue of Viruses is dedicated to exploring the cross-kingdom interactions that occur between viruses and bacteria in the gut and how these interactions influence health and disease. We hope to assemble a collection of research papers and reviews that will offer a comprehensive view on this emerging field, summarize our current understanding, and identify open research questions to stimulate future interdisciplinary collaborations. Topics may include (but are not limited to) the interplay between enteric viruses and the microbiota, the results of these interactions on the host immune response and cellular physiology in the intestine, structure–function studies of these interactions along the intestinal tract, the role of the virome in modulating host health and disease, and therapeutic strategies involving commensal bacteria and/or viruses to treat intestinal disease.

Dr. Melissa Jones
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • interplay between viruses, bacteria and the host
  • intestinal immune response to viruses
  • intestinal immune modulation by microbiota/viruses
  • intestinal physiology in response to pathogenic and commensal viruses
  • modulation of intestinal physiology by microbiota/bacteria/viruses
  • structure of virus–bacteria interactions
  • models of intestinal infections
  • therapeutic interventions.

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Published Papers (1 paper)

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Research

25 pages, 20112 KiB  
Article
Multiomics Analysis Reveals Gut Virome–Bacteria–Metabolite Interactions and Their Associations with Symptoms in Patients with IBS-D
by Peiwei Xie, Mei Luo, Jiahui Fan and Lishou Xiong
Viruses 2024, 16(7), 1054; https://doi.org/10.3390/v16071054 - 29 Jun 2024
Viewed by 1458
Abstract
The gut microbiota is involved in the pathogenesis of diarrhea-predominant irritable bowel syndrome (IBS-D), but few studies have focused on the role of the gut virome in IBS-D. We aimed to explore the characteristics of the gut virome in patients with IBS-D, its [...] Read more.
The gut microbiota is involved in the pathogenesis of diarrhea-predominant irritable bowel syndrome (IBS-D), but few studies have focused on the role of the gut virome in IBS-D. We aimed to explore the characteristics of the gut virome in patients with IBS-D, its interactions with bacteria and metabolites, and the associations between gut multiomics profiles and symptoms. This study enrolled twelve patients with IBS-D and eight healthy controls (HCs). The stool samples were subjected to metavirome sequencing, 16S rRNA gene sequencing, and untargeted metabolomic analysis. The participants completed relevant scales to assess the severity of their gastrointestinal symptoms, depression, and anxiety. The results revealed unique DNA and RNA virome profiles in patients with IBS-D with significant alterations in the abundance of contigs from Siphoviridae, Podoviridae, Microviridae, Picobirnaviridae, and Tombusviridae. Single-omics co-occurrence network analyses demonstrated distinct differences in the gut virus, bacteria, and metabolite network patterns between patients with IBS-D and HCs. Multiomics networks revealed that short-chain fatty acid-producing bacteria occupied more core positions in IBS-D networks, but had fewer links to viruses. Amino acids and their derivatives exhibit unique connectivity patterns and centrality features within the IBS-D network. The gastrointestinal and psychological symptom factors of patients with IBS-D were highly clustered in the symptom–multiomics network compared with those of HCs. Machine learning models based on multiomics data can distinguish IBS-D patients from HCs and predict the scores of gastrointestinal and psychological symptoms. This study provides insights into the interactions among gut viruses, bacteria, metabolites, and clinical symptoms in patients with IBS-D, indicating further classification and personalized treatment for IBS-D. Full article
(This article belongs to the Special Issue Enteric Viruses, Bacteria, and the Virome in Health and Disease)
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