Virus Assembly and Genome Packaging

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 2858

Special Issue Editor


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Guest Editor
1. Research Center for Health Sciences and Biomedicine (CICSaB), Universidad Autónoma de San Luis Potosí (UASLP), Av. Sierra Leona 550 Lomas 2da Seccion, San Luis Potosi 72810, Mexico
2. Department of Sciences, Universidad Autónoma de San Luis Potosí (UASLP), Av. Chapultepec 1570, Privadas del Pedregal, San Luis Potosi 78295, Mexico
Interests: VLP-based vaccines; RNA viruses; coronaviruses; viral assembly; arboviviruses
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Special Issue Information

Dear Colleagues,

Virus assembly is a key step of the infectious cycle and is the consequence of a series of well-orchestrated steps that must occur between the viral structural proteins and genome at the right time and in the right place. Furthermore, there are viruses in which assembly and packaging also depend on the interaction between viral and host proteins. This process depends on several aspects, such as the type of host cell and the organelle(s) where assembly occurs, the nature of the genome (ss vs. ds), and the viral genomic replication mechanism. Unfortunately, the molecular mechanism of virion assembly and genome packaging for most viruses is still not fully understood. Interestingly, this mechanism for virion assembly and/or genome packaging could be conserved between different viral species of the same family, and thus, the understanding of these processes could lead not only to understanding the molecular and physical mechanisms that control them but also to the development of novel antiviral therapies that could disrupt the infectious cycle.

Prof. Dr. Mauricio Comas-Garcia
Guest Editor

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Keywords

  • viral assembly
  • genome packaging
  • viral structural proteins
  • host protein
  • viral–host interactions
  • antiviral therapies

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Published Papers (1 paper)

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Research

18 pages, 4926 KiB  
Article
Comparative Atlas of SARS-CoV-2 Substitution Mutations: A Focus on Iranian Strains Amidst Global Trends
by Mohammad Hadi Abbasian, Karim Rahimian, Mohammadamin Mahmanzar, Saleha Bayat, Donna Lee Kuehu, Mahsa Mollapour Sisakht, Bahman Moradi and Youping Deng
Viruses 2024, 16(8), 1331; https://doi.org/10.3390/v16081331 - 20 Aug 2024
Viewed by 1885
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new emerging coronavirus that caused coronavirus disease 2019 (COVID-19). Whole-genome tracking of SARS-CoV-2 enhanced our understanding of the mechanism of the disease, control, and prevention of COVID-19. Methods: we analyzed 3368 SARS-CoV-2 protein [...] Read more.
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new emerging coronavirus that caused coronavirus disease 2019 (COVID-19). Whole-genome tracking of SARS-CoV-2 enhanced our understanding of the mechanism of the disease, control, and prevention of COVID-19. Methods: we analyzed 3368 SARS-CoV-2 protein sequences from Iran and compared them with 15.6 million global sequences in the GISAID database, using the Wuhan-Hu-1 strain as a reference. Results: Our investigation revealed that NSP12-P323L, ORF9c-G50N, NSP14-I42V, membrane-A63T, Q19E, and NSP3-G489S were found to be the most frequent mutations among Iranian SARS-CoV-2 sequences. Furthermore, it was observed that more than 94% of the SARS-CoV-2 genome, including NSP7, NSP8, NSP9, NSP10, NSP11, and ORF8, had no mutations when compared to the Wuhan-Hu-1 strain. Finally, our data indicated that the ORF3a-T24I, NSP3-G489S, NSP5-P132H, NSP14-I42V, envelope-T9I, nucleocapsid-D3L, membrane-Q19E, and membrane-A63T mutations might be responsible factors for the surge in the SARS-CoV-2 Omicron variant wave in Iran. Conclusions: real-time genomic surveillance is crucial for detecting new SARS-CoV-2 variants, updating diagnostic tools, designing vaccines, and understanding adaptation to new environments. Full article
(This article belongs to the Special Issue Virus Assembly and Genome Packaging)
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