Viral Hemorrhagic Disease

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1044

Special Issue Editors


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Guest Editor
Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
Interests: host–pathogen interaction; virology; immunology; pathogenesis

E-Mail Website
Guest Editor
Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
Interests: qRT-PCR; virology; vaccines; DNA vaccine; molecular virology; antivirals; ticks; molecular cloning

Special Issue Information

Dear Colleagues,

Haemorrhagic fever viruses (HFVs) constitute a broad group of unrelated pathogens that include family members of the Arenaviridae, Filoviridae, Flaviviridae, Hantaviridae, Nairoviridae, and Phenuiviridae, among others. HFVs can spread to humans by rodent and insect vectors, or by direct human-to-human transmission. These viruses produce a spectrum of human illnesses ranging from mild, marginally symptomatic to life-threatening and catastrophic. Viral and host factors influencing such diametrically opposed outcomes are not well understood. Furthermore, more evidence suggests that several HFVs can persistently infect their host and re-emerge months or years after the primary infection. Such recrudescence has resulted in sexual transmission to uninfected humans. This Special Issue, entitled "Viral Hemorrhagic Disease", seeks to present state-of-the-art research on these key aspects of HFVs and serve as a reference point that increases our understanding of the HFV host–pathogen relationship and identifies intervention strategies that prevent severe outcomes. Key topics for this Special Issue include, but are not limited to, the following:

  • Host factors contributing to severe disease;
  • Immune correlates of protection;
  • Animal models;
  • Persistent infections;
  • Surveillance of hemorrhagic fever viruses;
  • Prophylactic and therapeutic development against hemorrhagic fever viruses.

Reviews, original research, and communications are all welcome.

Dr. Joseph W. Golden
Dr. Aura R. Garrison
Guest Editors

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Keywords

  • host factors contributing to severe disease
  • immune correlates of protection
  • animal models
  • persistent infections
  • surveillance of hemorrhagic fever viruses
  • prophylactic and therapeutic development against hemorrhagic fever viruses

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Published Papers (1 paper)

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Research

14 pages, 1761 KiB  
Article
Serological Evidence of Hantavirus in Bats from the Brazilian Atlantic Forest: An Investigation of Seroreactivity and Cross-Reactivity of Neotropical Bat Samples Using Nucleoproteins of Rodent- and Bat-Borne Hantaviruses
by Caroline Lacorte Rangel, Silvia da Silva Fontes, Marcus Vinicius de Mattos Silva, Jorlan Fernandes, Janaina Figueira Mansur, Emmanuel Messias Vilar, Sócrates Fraga da Costa-Neto, Roberto Leonan Morim Novaes, Pedro Cordeiro-Estrela, Ricardo Moratelli, Elba Regina Sampaio de Lemos, Ronaldo Mohana Borges, Rodrigo Nunes Rodrigues-da-Silva and Renata Carvalho de Oliveira
Viruses 2024, 16(12), 1857; https://doi.org/10.3390/v16121857 - 29 Nov 2024
Viewed by 720
Abstract
Hantaviruses are zoonotic pathogens associated with severe human diseases such as hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Despite the extensive study of rodent-borne hantaviruses, research on bat-associated hantaviruses remains limited. This study aimed to investigate the seroprevalence and cross-reactivity of [...] Read more.
Hantaviruses are zoonotic pathogens associated with severe human diseases such as hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Despite the extensive study of rodent-borne hantaviruses, research on bat-associated hantaviruses remains limited. This study aimed to investigate the seroprevalence and cross-reactivity of neotropical bat samples with rodent- and bat-associated recombinant hantavirus nucleoproteins (rNPs) to improve hantavirus surveillance in the Brazilian Atlantic Forest. The studied bat population consisted of 336 blood samples collected over nearly a decade in five Brazilian states (Bahia, Rio de Janeiro, Santa Catarina, Paraná, and Minas Gerais). Antibodies were detected using IgG ELISA assays with rNPs from bat-borne Mobatvirus xuansonense (XSV) and Loanvirus brunaense (BRNV) and the rodent-borne hantaviruses Orthohantavirus andesense (ANDV) and Orthohantavirus seoulense (SEOV). Results indicated a higher seroprevalence for the BRNV rNP (36.6%) compared to ANDV (7.4%), SEOV (5.7%), and XSV (0.6%). The high sensitivity of the BRNV rNP and the cross-reactivity observed with the ANDV rNP, the main protein used for serological tests in the Americas, indicates that BRNV rNP is a better antigen for the accurate detection of antibodies against hantaviruses in Brazilian bats. These findings underscore the presence of unknown hantaviruses antigenically similar to BRNV in Brazilian bat populations and highlight the urgent need for identifying better antigens for comprehensive hantavirus monitoring in bats. Full article
(This article belongs to the Special Issue Viral Hemorrhagic Disease)
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