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Antioxidants
Special Issues
Plant Antioxidants, Inflammation, and Chronic Disease
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Plant Antioxidants, Inflammation, and Chronic Disease

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 25 November 2024 | Viewed by 2706

Special Issue Editors

Prof. Dr. Hae-Jeung Lee

E-Mail Website
Guest Editor
1. Department of Food and Nutrition, College of Bio-Nano Technology, Gachon University, Seongnam-si 13120, Republic of Korea
2. Gachon Advanced Institute for Health Science and Technology (GAIHST), Gachon University, Incheon 21999, Republic of Korea
3. Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, Republic of Korea
Interests: bioactive compounds; phytochemicals; antioxidants; inflammation; brown cell; chronic diseases; in vitro mechanism
Special Issues, Collections and Topics in MDPI journals
Dr. Jin Ah Cho

E-Mail Website
Guest Editor
Department of Food and Nutrition, Chungnam National University, Daejeon 34134, Republic of Korea
Interests: human nutrition; antioxidants; plant extracts; human health; inflammation; brain–gut axis; mucosal immunology

Special Issue Information

Dear Colleagues,

Plant antioxidants are abundantly present in various plant-based foods, such as fruits, vegetables, nuts, seeds, and whole grains. These antioxidants include vitamins such as vitamin C and vitamin E, minerals such as selenium, phytochemicals such as carotenoids, and polyphenols.

Plant antioxidants play a crucial role in the natural defense mechanism by neutralizing free radicals, reducing oxidative stress, supporting immune function and skin/eye health, improving cognitive function, and delaying aging, thus preventing the onset of chronic conditions.

This Special Issue highlights the importance of a diet rich in plant-based antioxidants to bolster immune function, thereby lowering the risk of chronic disease development and improving long-term health outcomes.

Prof. Dr. Hae-Jeung Lee
Dr. Jin Ah Cho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant antioxidants
  • free radicals
  • oxidative stress
  • polyphenol
  • carotenoids
  • vitamin C
  • vitamin E
  • selenium
  • inflammation
  • chronic disease
  • cardiovascular diseases
  • diabetes
  • cancer, neurodegenerative disorders
  • immune function

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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17 pages, 2847 KiB  
Article
Bioactivities of Quinic Acids from Vitex rotundifolia Obtained by Supercritical Fluid Extraction
by Duc Dat Le, Young Su Jang, Vinhquang Truong, Soojung Yu, Thientam Dinh and Mina Lee
Antioxidants 2024, 13(10), 1235; https://doi.org/10.3390/antiox13101235 - 14 Oct 2024
Viewed by 661
Abstract
Acyl-quinic acids (AQAs), present in various plants with many health benefits, are regarded as therapeutic agents in the prevention and treatment of chronic and cardiovascular diseases. The molecular network-guided identification of ten AQA compounds, two new (5 and 7) and eight [...] Read more.
Acyl-quinic acids (AQAs), present in various plants with many health benefits, are regarded as therapeutic agents in the prevention and treatment of chronic and cardiovascular diseases. The molecular network-guided identification of ten AQA compounds, two new (5 and 7) and eight known compounds, were isolated from V. rotundifolia L. f. by using a newly applied extraction method. Their structures were determined through spectroscopic means, reaction mixtures, and modified Mosher and PGME techniques. These compounds were assessed for their anti-inflammatory and antioxidant capabilities. Notably, compounds 1, 3, 4, 6, 8, and 9 exhibited notable DPPH radical scavenging activity. In LPS-induced HT-29 cells, compounds 2–7 significantly inhibited IL-8 production. Furthermore, compounds 3–5 and 7 markedly suppressed NO production, while compounds 1–10 effectively inhibited IL-6 production in LPS-induced RAW264.7 cells. Western blot analyses revealed that compounds 3–5, and 7 reduced iNOS and COX-2 expression, and compounds 2–5, 7, and 8 also diminished the expression levels of p38 MAPK phosphorylation. Docking studies demonstrated the active compounds’ binding affinity with the IL-8, iNOS, COX-2, and p38 MAPK proteins through interactions with essential amino acids within the binding pockets of complexes. The findings suggest that compounds 1, 3, 4, 6, 8, and 9, and compounds 3–5, and 7, hold promise as potential therapeutic agents for treating antioxidative and inflammatory diseases, respectively. Full article
(This article belongs to the Special Issue Plant Antioxidants, Inflammation, and Chronic Disease)
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16 pages, 2591 KiB  
Article
Chemical Composition Analysis and Assessment of Antioxidant and Anti-Inflammatory Activities of Crude Extract of Flueggea leucopyrus on Carrageenan-Induced Paw Edema in Wistar Albino Rats
by Vijayakumar Mayakrishnan, Anand Thirupathi, Kavitha Ramamoorthy, Kaliappan Annadurai, Radha Prakasam, Yaodong Gu, Choon Young Kim, Mahadevi Ramasamy, Habeebmon Karimpanchola, Priya Kannappan, Natesan Vijayakumar, Bhuvaneshwari Venkatesan Kumari and Anand Singaravelu
Antioxidants 2024, 13(8), 976; https://doi.org/10.3390/antiox13080976 - 12 Aug 2024
Viewed by 1057
Abstract
A member of the Phyllanthaceae family, Flueggea leucopyrus is a well-known plant in the tribal areas of Sri Lanka, India’s Shaurastra region, Australia, and Malaysia. This study provides information about Flueggea leucopyrus, a plant with a wide range of therapeutic uses in [...] Read more.
A member of the Phyllanthaceae family, Flueggea leucopyrus is a well-known plant in the tribal areas of Sri Lanka, India’s Shaurastra region, Australia, and Malaysia. This study provides information about Flueggea leucopyrus, a plant with a wide range of therapeutic uses in India. Different extracts from the leaves and roots of Flueggea leucopyrus were evaluated for their physical and chemical properties, preliminary phytochemical parameters, and pharmacological activities in the current study, followed by their fourier transform infrared spectroscopy (FTIR), gas chromatography-mass spectrometry (GC–MS), antioxidant, and anti-inflammatory properties. The aqueous extract of Flueggea leucopyrus leaves and roots have more different phytochemical elements than other solvent extracts, according to physico-chemical tests and phytochemical screening. As a result, the FT-IR, GC–MS, antioxidant, and anti-inflammatory activities of an aqueous extract were tested. Studies on hind paw edemas caused by carrageenan in albino rats examined the mean increase in paw volume and the percentage inhibition in paw volume at various time points following the injection of carrageenan (1% w/v). In comparison to the norm, these inhibitions were statistically significant (p < 0.001). The aqueous extract of Flueggea leucopyrus leaves and roots have both antioxidative and anti-inflammatory activities, indicating that it has the potential to be used in the formulation of antioxidant and anti-inflammatory medications in the future. Full article
(This article belongs to the Special Issue Plant Antioxidants, Inflammation, and Chronic Disease)
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Review

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38 pages, 3234 KiB  
Review
A Review on the Protecting Effects and Molecular Mechanisms of Berries Against a Silent Public Health Concern: Non-Alcoholic Fatty Liver Disease
by Anshul Sharma and Hae-Jeung Lee
Antioxidants 2024, 13(11), 1389; https://doi.org/10.3390/antiox13111389 - 14 Nov 2024
Viewed by 552
Abstract
Non-alcoholic fatty liver disease (NAFLD) poses a silent threat to human health, with prevalence rising at an alarming rate. The treatment and prevention of NAFLD depend on novel approaches as no effective treatment options are currently available. Berries are unique sources of phenolic [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) poses a silent threat to human health, with prevalence rising at an alarming rate. The treatment and prevention of NAFLD depend on novel approaches as no effective treatment options are currently available. Berries are unique sources of phenolic compounds that have proven roles in disease prevention and health promotion. However, a comprehensive review of the effects of different berries on NAFLD and related pathologies is lacking. Thus, the present review aims to summarize the effects of berry extracts, plant parts, and bioactive compounds from twenty-one different berries on NAFLD. The molecular mechanisms involved include the regulation of lipid homeostasis, modulation of oxidative stress and inflammation markers, and activation of different signaling pathways in different in vitro and in vivo NAFLD models. Furthermore, their modulatory effects on the gut microbiota have also been highlighted. Clinical intervention research on the benefits of berries in NAFLD is limited; nonetheless, this paper discusses clinical studies demonstrating the effects of different berries in people with NAFLD. Future research should focus on long-term clinical studies to compare the therapeutic potentials of different berries against NAFLD. Full article
(This article belongs to the Special Issue Plant Antioxidants, Inflammation, and Chronic Disease)
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