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Antioxidants
Special Issues
Redox Regulation in Cardiovascular Diseases
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Redox Regulation in Cardiovascular Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 17 March 2025 | Viewed by 1552

Special Issue Editors

Dr. Yiliang Chen

E-Mail Website
Guest Editor
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
Interests: atherosclerosis; ROS; lipid signals; macrophage; single cell RNA sequencing; immunometabolism
Dr. Jacek Zielonka

E-Mail Website
Co-Guest Editor
Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Interests: antioxidants; redox chemistry; probes; probe design and synthesis; free radicals; cellular bioenergetics

Special Issue Information

Dear Colleagues,

Cardiovascular diseases (CVDs) remain the main cause of death worldwide. While numerous factors facilitate the onset of CVD, oxidative stress, caused by an imbalance between oxidants and antioxidants, is a major contributor. While oxygen gas is used in vascular cells to carry out their physiological functions, free radicals, including reactive oxygen species (ROS) and reactive nitrogen species (RNS), are generated either as side products or as important regulators themselves. These chemically highly reactive molecules, if left unrestricted, have the potential to modify proteins, lipids, and nucleic acids, which cause oxidative stress and cell damage. Therefore, oxidants reach physiological equilibrium with various antioxidant enzymes and molecules in a healthy body. However, a major challenge for vascular cells in maintaining the redox balance is that they often face a constantly changing surrounding environment (e.g., fluctuation of nutrients, hormones, mechanical forces, invading pathogens, etc.), which requires them to adapt to it in a timely manner. Recent findings suggest that maladaptation in redox status leads to oxidative stress and chronic inflammation, promoting CVD.

This Special Issue will focus on the mechanisms of redox regulation during CVD development and discuss potential strategies for the re-establishment of redox balance.

Dr. Yiliang Chen
Dr. Jacek Zielonka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • mitochondria
  • metabolism
  • chronic inflammation
  • atherosclerosis
  • CVD
  • ROS

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Published Papers (2 papers)

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Research

17 pages, 10811 KiB  
Article
Data-Driven Insights into the Association Between Oxidative Stress and Calcium-Regulating Proteins in Cardiovascular Disease
by Namuna Panday, Dibakar Sigdel, Irsyad Adam, Joseph Ramirez, Aarushi Verma, Anirudh N. Eranki, Wei Wang, Ding Wang and Peipei Ping
Antioxidants 2024, 13(11), 1420; https://doi.org/10.3390/antiox13111420 - 20 Nov 2024
Viewed by 459
Abstract
A growing body of biomedical literature suggests a bidirectional regulatory relationship between cardiac calcium (Ca2+)-regulating proteins and reactive oxygen species (ROS) that is integral to the pathogenesis of various cardiac disorders via oxidative stress (OS) signaling. To address the challenge of [...] Read more.
A growing body of biomedical literature suggests a bidirectional regulatory relationship between cardiac calcium (Ca2+)-regulating proteins and reactive oxygen species (ROS) that is integral to the pathogenesis of various cardiac disorders via oxidative stress (OS) signaling. To address the challenge of finding hidden connections within the growing volume of biomedical research, we developed a data science pipeline for efficient data extraction, transformation, and loading. Employing the CaseOLAP (Context-Aware Semantic Analytic Processing) algorithm, our pipeline quantifies interactions between 128 human cardiomyocyte Ca2+-regulating proteins and eight cardiovascular disease (CVD) categories. Our machine-learning analysis of CaseOLAP scores reveals that the molecular interfaces of Ca2+-regulating proteins uniquely associate with cardiac arrhythmias and diseases of the cardiac conduction system, distinguishing them from other CVDs. Additionally, a knowledge graph analysis identified 59 of the 128 Ca2+-regulating proteins as involved in OS-related cardiac diseases, with cardiomyopathy emerging as the predominant category. By leveraging a link prediction algorithm, our research illuminates the interactions between Ca2+-regulating proteins, OS, and CVDs. The insights gained from our study provide a deeper understanding of the molecular interplay between cardiac ROS and Ca2+-regulating proteins in the context of CVDs. Such an understanding is essential for the innovation and development of targeted therapeutic strategies. Full article
(This article belongs to the Special Issue Redox Regulation in Cardiovascular Diseases)
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11 pages, 783 KiB  
Article
Different Oxidative Stress and Inflammation Patterns of Diseased Left Anterior Descending Coronary Artery versus Internal Thoracic Artery
by Andrea Salica, Vittoria Cammisotto, Raffaele Scaffa, Giulio Folino, Ruggero De Paulis, Roberto Carnevale, Umberto Benedetto, Wael Saade, Antonino Marullo, Sebastiano Sciarretta, Gianmarco Sarto, Silvia Palmerio, Valentina Valenti, Mariangela Peruzzi, Fabio Miraldi, Francesco Giosuè Irace and Giacomo Frati
Antioxidants 2024, 13(10), 1180; https://doi.org/10.3390/antiox13101180 - 28 Sep 2024
Viewed by 652
Abstract
Background. Oxidative stress and inflammation are typically implied in atherosclerosis pathogenesis and progression, especially in coronary artery disease (CAD). Our objective was to investigate the oxidative stress and inflammation burden directly associated with atherosclerotic plaque in patients with stable coronary disease undergoing coronary [...] Read more.
Background. Oxidative stress and inflammation are typically implied in atherosclerosis pathogenesis and progression, especially in coronary artery disease (CAD). Our objective was to investigate the oxidative stress and inflammation burden directly associated with atherosclerotic plaque in patients with stable coronary disease undergoing coronary artery bypass graft (CABG) surgery. Specifically, markers of oxidative stress and inflammation were compared in blood samples obtained from the atherosclerotic left anterior descending artery (LAD) and blood samples obtained from the healthy left internal thoracic artery (LITA), used as a bypass graft, within the same patient. Methods. Twenty patients scheduled for off-pump CABG were enrolled. Blood samples were collected from the LITA below anastomosis and the LAD below the stenosis. Samples were analysed for oxidative stress (sNOXdp, H2O2, NO) and inflammation markers (TNFα, IL-6, IL-1β, IL-10). Results. The analysis showed a significant increase in oxidative stress burden in the LAD as compared to LITA, as indicated by higher sNOX2-dp and H2O2 levels and lower NO levels (p < 0.01). Also, pro-inflammatory cytokines were increased in the LAD as compared to the LITA, as indicated by higher TNFα and IL-6 amounts (p < 0.01). On the other hand, no significant differences could be seen regarding IL-1β and IL-10 levels between the two groups. Conclusions. The oxidative stress and inflammatory burden are specifically enhanced in the LAD artery of stable coronary patients compared to systemic blood from the LITA of stable coronary patients. Full article
(This article belongs to the Special Issue Redox Regulation in Cardiovascular Diseases)
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