Oxidative Stress and Vascular Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 1911
Special Issue Editors
Interests: coronary artery disease; cardiovascular diseases; oxidative stress; heart
Special Issue Information
Dear Colleagues,
Oxidative stress is involved in vascular diseases such as hypertension, atherosclerosis, aortic aneurysm, and aortic dissection. Oxidative stress is a state in which reactive oxygen species (ROS) are more than their antioxidant activity. ROS are produced in blood vessels mainly by the mitochondrial electron transfer system, NAD(P)H oxidase, xanthine oxidase, and uncoupling of nitric oxide synthase. ROS act on various tissues, including vascular endothelial, smooth muscle, and perivascular tissues. However, because the half-life of ROS is generally short, it is unlikely that ROS act over a wide area, and local redox balance must be considered. Furthermore, physiological amounts of ROS act as messengers in the signal transduction pathway, and redox signaling regulates gene expression, cell proliferation, migration, and cell death, making the pathogenesis complex and therapeutic intervention difficult. In fact, numerous clinical trials have been conducted to inhibit ROS with the aim of reducing oxidative stress. Still, unfortunately, no evidence of the efficacy of antioxidant therapy has been demonstrated in humans.
This Special Issue aims to stimulate discussion and highlight the latest developments in how oxidative stress acts on vascular disease. A comprehensive understanding of the effects of ROS on blood vessels will assist in developing new therapeutic strategies and drugs for vascular disease. The journal welcomes review articles and original research papers addressing all relevant basic and clinical topics in the above areas.
Prof. Dr. Takeshi Adachi
Dr. Yasunaga Shiraishi
Guest Editors
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Keywords
- oxidative stress
- antioxidant
- reactive oxygen species
- antioxidants
- vascular diseases
- endothelial dysfunction
- hypertension
- atherosclerosis
- aortic disease
- vascular hypertrophy
- NAD(P)H oxidase
- mitochondria
- nitric oxide synthase
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