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Antioxidants
Special Issues
Antioxidant and Cytotoxic Effects of Phytochemicals
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Antioxidant and Cytotoxic Effects of Phytochemicals

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 5653

Special Issue Editors

Dr. José Miguel P. Ferreira de Oliveira

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Guest Editor
LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
Interests: phytochemicals; oxidative stress; cancer; genotoxicity; in vitro toxicology; cancer cell death; nanotoxicology
Special Issues, Collections and Topics in MDPI journals
Dr. Daniela Ribeiro

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Guest Editor
Institute of Agricultural and Environmental Research and Technology (IITAA), University of the Azores, Angra do Heroísmo, Portugal
Interests: biological chemistry; antioxidants; anti-inflammatories; bioactive compounds; polyphenols
Special Issues, Collections and Topics in MDPI journals
Dr. Helena Oliveira

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Guest Editor
Department of Biology, CESAM—Centre for Environmental and Marine Studies, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: cytotoxicity; genotoxicity; nanoparticles for biological applications; nanotoxicity; drug delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Verónica Bastos

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Guest Editor
Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: in vitro cell culture; cytotoxicity; genotoxicity; cancer therapy; nanobiomedicine; nanotoxicology; human health; environmental toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Phytochemicals are plant metabolites with diverse functions, including protection against biotic and abiotic stress. Oxidative stress and reactive species (RS) accumulation are pathological features that are intrinsically related to the development of cancer-related diseases. The antioxidant properties of phytochemicals have been linked to their ability to scavenge RS and prevent cellular damage caused by oxidative stress. Additionally, many phytochemicals have been shown to exhibit cytotoxic effects against cancer cells, including proapoptotic effects, making them attractive therapeutic agents.

This Special Issue welcomes original research and reviews on the antioxidant and cytotoxic effects of phytochemicals. Articles pertaining to the physicochemical properties, bioactivity, and cell delivery of phytochemicals, and their potential use as therapeutic agents for cancer and other diseases, are welcome. This research covers both in vitro and in vivo studies related to any of the following topics: phytochemicals’ structure–function relationship; reactive species scavenging or the modulation of their production; the role of phytochemicals in antioxidant defense systems and pathways; inflammation; mitochondrial disfunction; DNA damage; cancer cell death; and optimal drug delivery.

We look forward to receiving your contributions.

Dr. José Miguel P. Ferreira de Oliveira
Dr. Daniela Ribeiro
Dr. Helena Oliveira
Dr. Verónica Bastos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phenolic compounds
  • Nrf2
  • reactive species
  • phytochemistry
  • plant natural products
  • redox signaling
  • oxidative stress
  • antioxidant systems
  • cellular damage
  • cell death pathways
  • drug delivery

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Published Papers (2 papers)

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Research

18 pages, 5524 KiB  
Article
Gossypetin Is a Novel Modulator of Inflammatory Cytokine Production and a Suppressor of Osteosarcoma Cell Growth
by Carina Proença, Ana Teresa Rufino, Isabela Santos, Hélio M. T. Albuquerque, Artur M. S. Silva, Eduarda Fernandes and José Miguel P. Ferreira de Oliveira
Antioxidants 2023, 12(9), 1744; https://doi.org/10.3390/antiox12091744 - 10 Sep 2023
Cited by 6 | Viewed by 1697
Abstract
Osteosarcoma (OS) is a common childhood sarcoma, and its treatment is hindered by adverse effects, chemoresistance, and recurrence. Interleukin (IL)-6 production by tumors plays a significant role in inflammation, carcinogenesis, and metastasis. This study aimed to investigate the antiproliferative potential of luteolin derivatives [...] Read more.
Osteosarcoma (OS) is a common childhood sarcoma, and its treatment is hindered by adverse effects, chemoresistance, and recurrence. Interleukin (IL)-6 production by tumors plays a significant role in inflammation, carcinogenesis, and metastasis. This study aimed to investigate the antiproliferative potential of luteolin derivatives in OS and to evaluate interleukin production. MG-63, Saos-2, HOS, and 143B human OS cell lines were incubated with luteolin and eight derivatives containing hydroxy, chlorine, or alkyl substitutions. The cell viability and growth were evaluated in the presence of these compounds. Apoptosis was also examined through the analysis of the Bax expression and caspase-3 activity. Finally, the gossypetin effects were measured regarding the production of proinflammatory cytokines interleukin (IL)-6, IL-1β, and IL-12p70. Our findings show that gossypetin was the most potent compound, with proliferation-suppressing activities that induced a series of critical events, including the inhibition of the cell viability and growth. Apoptosis was associated with enhanced caspase-3 activity and increased Bax expression, indicating the involvement of the intrinsic pathway of apoptosis. Moreover, pre-/co-treatment with gossypetin significantly reduced the autocrine production of proinflammatory cytokines. Further investigation is required; nevertheless, considering the link between inflammation, carcinogenesis, and metastasis in OS, our findings suggest that gossypetin exhibits anti-proliferative and anti-inflammatory properties that are potentially relevant in the clinical context. Full article
(This article belongs to the Special Issue Antioxidant and Cytotoxic Effects of Phytochemicals)
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14 pages, 5358 KiB  
Communication
Antioxidant and Cytotoxic Potential of Carlina vulgaris Extract and Bioactivity-Guided Isolation of Cytotoxic Components
by Ireneusz Sowa, Roman Paduch, Jarosław Mołdoch, Dariusz Szczepanek, Jacek Szkutnik, Paweł Sowa, Katarzyna Tyszczuk-Rotko, Tomasz Blicharski and Magdalena Wójciak
Antioxidants 2023, 12(9), 1704; https://doi.org/10.3390/antiox12091704 - 1 Sep 2023
Cited by 3 | Viewed by 3260
Abstract
Carlina vulgaris is a poorly understood plant in the context of biological activity, despite its widespread application in ethnomedicine in numerous European countries. The aim of this study was to assess the cytotoxic potential of the plant against human colorectal adenocarcinoma (HT29) and [...] Read more.
Carlina vulgaris is a poorly understood plant in the context of biological activity, despite its widespread application in ethnomedicine in numerous European countries. The aim of this study was to assess the cytotoxic potential of the plant against human colorectal adenocarcinoma (HT29) and to isolate the plant components linked to this effect. Ultra-high performance liquid chromatography with a high-resolution/quadrupole time-of-flight mass spectrometer (UHPLC–HR/QTOF/MS–PDA) was used for the phytochemical characterization of the extract. Liquid–liquid extraction and preparative chromatography were employed for fractionation purposes. Our investigation demonstrated that the ethyl acetate fraction from C. vulgaris showed significant cytotoxicity, and a bioactivity-guided approach led to the isolation of oxylipins, including traumatic acid, pinellic acid, and 9,10-dihydroxy-8-oxsooctadec-12-enic acid. The structures of the compounds were confirmed by nuclear magnetic resonance spectroscopy. Among these compounds, the last one exhibited significant cytotoxicity, though without selectivity, and traumatic acid was characterized by mild cytotoxicity. The cytotoxicity was linked to intracellular reactive oxygen species generation. Full article
(This article belongs to the Special Issue Antioxidant and Cytotoxic Effects of Phytochemicals)
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