The Use of Antioxidant-Rich Foods and Supplements in Disease Prevention

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 5900

Special Issue Editors


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Guest Editor
Biomedical Sciences Institute, Autonomous University of Ciudad Juarez, Ciudad Juarez, Chihuahua, Mexico
Interests: phenolic compounds; nutrients; nutrition physiology; public health; nutritional status; nutrition; anthropometry; physical activity; metabolic syndrome; cardiovascular; antioxidants; food chemistry; community nutrition
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Baja California, Mexico
Interests: biophysics and biochemistry of macromolecules; nutraceuticals; functional foods; nutrition & dietetics; clinical nutrition; food science & technology

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Guest Editor
Centro de Investigacion en Alimentacion y Desarrollo, Sonora, Mexico
Interests: food science & technology of functional foods and nutraceuticals; plant antioxidants; QSAR modelling; pre/post-harvest technologies

Special Issue Information

Dear Colleagues,

Most of the chronic diseases (communicable/non-communicable) that plague our times have a close relationship with the body's redox status. Thus, traditional dietary patterns (e.g., Mediterranean) and personalized dietary regimens (e.g., based on foods' radical scavengers) have demonstrated, at both the epidemiological/clinical levels, their effectiveness in preventing and controlling many diseases associated with a plethora of oxidative stress markers. Concurrently, several food-derived nutraceuticals with antioxidant capacity have been isolated, chemically characterized, tested for their effectiveness (in in vitro, in vivo, and ex vivo models), and launched on the market, for either primary health promotion and/or as adjuvant therapeutic agents.

In this Special Issue of Antioxidants, we aim to address the state of the art of this topic, welcoming original research articles, narrative/systematic reviews, and communications focused on the preventive/therapeutic roles and molecular mechanisms associated with food-derived antioxidants and/or nutraceutical formulations based on them.

Dr. Abraham Wall Medrano
Dr. Escobar-Puentes Alberto A.
Dr. Gustavo Adolfo González-Águilar
Guest Editors

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Keywords

  • dietary antioxidants
  • bioactivity
  • metabolomics
  • human diet
  • xenobiotics
  • polyphenols
  • vitamins
  • health promotion

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Published Papers (1 paper)

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Research

20 pages, 2715 KiB  
Article
Characterization of Extractable and Non-Extractable Phenols and Betalains in Berrycactus (Myrtillocactus geometrizans) and Its Chemoprotective Effect in Early Stage of Colon Cancer In Vivo
by Rosa Iris Godínez-Santillán, Aarón Kuri-García, Iza Fernanda Ramírez-Pérez, María Guadalupe Herrera-Hernández, Santiaga Marisela Ahumada-Solórzano, Salvador Horacio Guzmán-Maldonado and Haydé Azeneth Vergara-Castañeda
Antioxidants 2024, 13(9), 1112; https://doi.org/10.3390/antiox13091112 - 14 Sep 2024
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Abstract
This research identified the bioactive compounds and antioxidant capacity of the extractable (EP) and non-extractable (NEP) polyphenol fractions of berrycactus (BC). Additionally, the effects of BC and its residue (BCR) on preventing AOM/DSS-induced early colon carcinogenesis were evaluated in vivo. Male Sprague Dawley [...] Read more.
This research identified the bioactive compounds and antioxidant capacity of the extractable (EP) and non-extractable (NEP) polyphenol fractions of berrycactus (BC). Additionally, the effects of BC and its residue (BCR) on preventing AOM/DSS-induced early colon carcinogenesis were evaluated in vivo. Male Sprague Dawley rats were randomly assigned to six groups (n = 12/group): healthy control (C), AOM/DSS, BC, BCR, BC+AOM/DSS, and BCR+AOM/DSS. NEP was obtained through acid hydrolysis using H2SO4 and HCl (1 M or 4 M). The HCl-NEP fraction exhibited the highest total phenolic and flavonoid content, while condensed tannins were more abundant in the H2SO4-NEP fraction. A total of 33 polyphenols were identified by UPLC-QTOF-MSE in both EP and NEP, some of which were novel to BC. Both NEP hydrolysates demonstrated significant total antioxidant capacity (TEAC), with HCl-NEP exhibiting the highest ORAC values. The BC+AOM/DSS and BCR+AOM/DSS groups exhibited fewer aberrant crypt foci (p < 0.05), reduced colonic epithelial injury, and presented lower fecal β-glucuronidase activity, when compared to AOM/DSS group. No differences in butyric acid concentrations were observed between groups. This study presents novel bioactive compounds in EP and NEP from BC that contribute to chemopreventive effects in early colon carcinogenesis, while reducing fecal β-glucuronidase activity and preserving colonic mucosal integrity. Full article
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