Oxidative Stress and Eye Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2492

Special Issue Editors


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Guest Editor
Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L'Aquila, Italy
Interests: retina; neurodegeneration; neuroprotection; retinal pigment epithelium; retinal function; age related macular degeneration; nanoparticles
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E-Mail Website
Guest Editor
Department of Biotechnological and Applied Clinical Sciences, Università degli Studi dell'Aquila, 67100 L'Aquila, Italy
Interests: retinal degeneration; neuroscience; age-related macular degeneration; electrophysiology; neurobiochemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The oxidative stress plays a major role in the pathogenesis of multiple ocular diseases, either in the anterior or in the posterior segment of the eye, and is at the base of a vicious cycle in which oxidative stress burden progressively accumulates. The impairment of the endogenous anti-oxidant defenses with aging also contributes to dysfunction and oxidative stress burden in such diseases. In this context, natural compounds, and nanotechnological and molecular approaches targeting the oxidative stress or prompting the rescue of anti-oxidant defenses represent challenging strategies for the development of therapies to delay/limit the progression of multiple diseases.

In this Special Issue we invite researchers to provide original research articles, clinical reports, and review articles that relate to oxidative stress and corneal (i.e., keratoconus), lens (i.e., cataract) and retinal (i.e., age-related macular degeneration) diseases. Additionally, studies on anti-oxidant therapeutic strategies may be submitted for evaluation.

Dr. Maccarone Rita
Dr. Annamaria Tisi
Guest Editors

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Keywords

  • oxidative stress
  • reactive oxygen species
  • ocular diseases
  • eye
  • retina
  • cornea
  • lens
  • antioxidant therapies
  • antioxidant compounds
  • antioxidant signalling

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Published Papers (1 paper)

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Review

12 pages, 1244 KiB  
Review
Protecting the Eye Lens from Oxidative Stress through Oxygen Regulation
by Witold Karol Subczynski, Marta Pasenkiewicz-Gierula and Justyna Widomska
Antioxidants 2023, 12(9), 1783; https://doi.org/10.3390/antiox12091783 - 20 Sep 2023
Cited by 2 | Viewed by 1879
Abstract
Molecular oxygen is a primary oxidant that is involved in the formation of active oxygen species and in the oxidation of lipids and proteins. Thus, controlling oxygen partial pressure (concentration) in the human organism, tissues, and organs can be the first step in [...] Read more.
Molecular oxygen is a primary oxidant that is involved in the formation of active oxygen species and in the oxidation of lipids and proteins. Thus, controlling oxygen partial pressure (concentration) in the human organism, tissues, and organs can be the first step in protecting them against oxidative stress. However, it is not an easy task because oxygen is necessary for ATP synthesis by mitochondria and in many biochemical reactions taking place in all cells in the human body. Moreover, the blood circulatory system delivers oxygen to all parts of the body. The eye lens seems to be the only organ that is protected from the oxidative stress through the regulation of oxygen partial pressure. The basic mechanism that developed during evolution to protect the eye lens against oxidative damage is based on the maintenance of a very low concentration of oxygen within the lens. This antioxidant mechanism is supported by the resistance of both the lipid components of the lens membrane and cytosolic proteins to oxidation. Any disturbance, continuous or acute, in the working of this mechanism increases the oxygen concentration, in effect causing cataract development. Here, we describe the biophysical basis of the mechanism and its correlation with lens transparency. Full article
(This article belongs to the Special Issue Oxidative Stress and Eye Diseases)
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