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Applied Sciences
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Advances in Gastrointestinal Cancer Research: A Molecular and Biological Perspective
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Advances in Gastrointestinal Cancer Research: A Molecular and Biological Perspective

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 1213

Special Issue Editors

Dr. Zsolt Kovacs

E-Mail Website
Guest Editor
Department of Biochemistry and Environmental Chemistry, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139 Târgu Mureș, Romania
Interests: GI cancer molecular biology; translational research; ASRB in cancer
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Simona Gurzu

E-Mail Website1 Website2
Guest Editor
George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 310377 Targu-Mures, Romania
Interests: cancer biology; GI cancer; molecular biology of cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, titled "Advances in Gastrointestinal Cancer Research: A Molecular and Biological Perspective”, aims to assemble a comprehensive collection of research articles that showcase groundbreaking advancements in the detection, understanding, and treatment of gastrointestinal (GI) cancers. Through a lens that deeply focuses on molecular biology and its interplay with clinical practices, this Special Issue offers insights into the complex biological mechanisms driving GI cancers, innovative diagnostic techniques, and novel therapeutic strategies. A portion of this Special Issue will be dedicated towards outlining the latest in diagnostic advancements. Here, contributors would explore noninvasive biomarkers, cutting-edge imaging techniques, and the integration of artificial intelligence to enhance the early detection and accurate staging of GI cancers. The significance of liquid biopsies in capturing the heterogeneity of tumors and monitoring treatment responses is also highlighted, marking a shift towards more personalized and less invasive monitoring approaches. This Special Issue also aims to delve into the critical role that the tumor microenvironment plays, as well as the biological interfaces that influence cancer progression and response to treatment. Investigations into the interactions between cancer cells and their microenvironment pave the way for therapies that disrupt these interactions or modify the microenvironment to inhibit cancer growth.

This Special Issue will serve as a testament to the vibrant and rapidly evolving field of GI cancer research, offering valuable insights and promising directions for scientists, clinicians, and patients alike.

Dr. Zsolt Kovacs
Prof. Dr. Simona Gurzu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • GI cancer
  • AI in GI cancer research
  • novel biomarkers in GI cancers
  • personalized treatment in GI cancer
  • tumor microenvironment

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Published Papers (1 paper)

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Research

10 pages, 2539 KiB  
Article
Synergistic Impact of ARSB, TP53, and Maspin Gene Expressions on Survival Outcomes in Colorectal Cancer: A Comprehensive Clinicopathological Analysis
by Zsolt Kovacs, Laura Banias, Eva Osvath and Simona Gurzu
Appl. Sci. 2024, 14(13), 5721; https://doi.org/10.3390/app14135721 - 30 Jun 2024
Cited by 1 | Viewed by 834
Abstract
(1) Background: Colorectal cancer (CRC) remains a significant cause of morbidity and mortality worldwide, with its prognosis influenced by genetic and clinicopathological factors. This study investigates the associations between the gene expressions of Arylsulfatase B (ARSB), TP53, and Maspin, alongside traditional clinicopathological features, [...] Read more.
(1) Background: Colorectal cancer (CRC) remains a significant cause of morbidity and mortality worldwide, with its prognosis influenced by genetic and clinicopathological factors. This study investigates the associations between the gene expressions of Arylsulfatase B (ARSB), TP53, and Maspin, alongside traditional clinicopathological features, and their impact on CRC survival outcomes. (2) Methods: 70 consecutive CRC cases were analyzed for ARSB, TP53, and Maspin gene expression using RT-qPCR, and their protein levels were assessed through immunohistochemistry. Clinicopathological parameters—age, gender, tumor localization, macroscopic and microscopic aspects, lymph node ratio, pT stage, and tumor budding—were evaluated for their prognostic significance. Kaplan–Meier survival analysis with Cox proportional hazards regression was used to determine their impact on overall survival. (3) Results: No significant survival differences were observed based on age, gender, tumor localization, and macroscopic aspect. The microscopic aspect and pT stage showed significant associations with survival, with poorer outcomes in G3 and pT3/pT4 stages, respectively. Immunohistochemical positivity for ARSB and Maspin indicated a longer survival, while TP53 protein expression alone did not significantly impact the prognosis. Dual high gene expression (ARSB + TP53, TP53 + Maspin) and triple high gene expression (ARSB + TP53 + Maspin) were significantly associated with better survival outcomes. (4) Conclusions: The combined gene expression profile of ARSB, TP53, and Maspin presents a novel prognostic marker in CRC, offering insights into the molecular dynamics of cancer cells and potential therapeutic targets. These findings emphasize the importance of integrating molecular markers with traditional clinicopathological factors for a more accurate prognostication and personalized treatment approach in CRC. Full article
(This article belongs to the Special Issue Advances in Gastrointestinal Cancer Research: A Molecular and Biological Perspective)
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