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Cancers
Special Issues
Histopathology and Diagnosis of Gastrointestinal Tumors
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Histopathology and Diagnosis of Gastrointestinal Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: closed (25 October 2024) | Viewed by 1774

Special Issue Editors

Prof. Dr. Ioan Jung

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Guest Editor
Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 38 Gheorghe Marinescu Street, 540139 Targu Mures, Romania
Interests: pathology; immunohistochemistry; oncogenesis; iatrogenic pathology; soft tissue tumors; gastrointestinal cancer
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Simona Gurzu

E-Mail Website
Guest Editor
Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 38 Gheorghe Marinescu Street, 540139 Targu Mures, Romania
Interests: oncopathology; gastric cancer; colorectal cancer; hepatocellular carcinoma; epithelial–mesenchymal transition; targeted therapy of cancer; histopathology; molecular pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is focused on the diagnosis of gastrointestinal cancer. As the diagnosis is established by a transdisciplinary team, the aim of this Special Issue is to collect papers referring to all the examinations necessary for a proper diagnosis of common cancers but also of rare types of tumors. The diagnosis involves gastroenterologists, imagisticians, surgeons, pathologists, and geneticists but other specialists in the field might also be involved. We welcome papers that involve histopathological analysis but papers on serum examinations and new trends in preoperative diagnosis are also welcomed to be explored. The investigations carried out for the prediction of prognosis or to indicate an individualized therapy might also be part of the Special Issue. Any research or review-type papers that include data focused on diagnosis, from serum to tissue biomarkers and circulating tumor cells, are welcome. If some papers are mainly based on in silico analysis or examination of public gene databases, they should include an external validation on their own cohort. Your individual contribution to research on diagnosis tools might be helpful for doctors involved in the diagnosis of gastrointestinal tumors and provide new hope for oncologic patients.

Prof. Dr. Ioan Jung
Prof. Dr. Simona Gurzu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • histopathology
  • immunohistochemistry
  • microRNAs
  • PET-CT
  • MRI
  • gene profile
  • oncology
  • pathology
  • gastric cancer
  • colorectal cancer
  • esophageal cancer
  • cholangiocarcinoma
  • serum biomarkers

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Published Papers (2 papers)

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Research

18 pages, 52984 KiB  
Article
Primitive Resectable Small Bowel Cancer Clinical–Pathological Analysis: A 10-Year Retrospective Study in a General Surgery Unit
by Cosmin Vasile Obleagă, Costin Teodor Streba, Cecil Sorin Mirea, Ionică Daniel Vîlcea, Dan Nicolae Florescu, Mihai Călin Ciorbagiu, Tudor Turcu, Mirela Marinela Florescu, Mircea Sebastian Șerbănescu, Alina-Maria Mehedințeanu and Cristin Constantin Vere
Cancers 2024, 16(21), 3713; https://doi.org/10.3390/cancers16213713 - 4 Nov 2024
Viewed by 641
Abstract
Introduction: Small bowel cancer is very rare; although the incidence of adenocarcinoma and other anatomopathological forms has increased recently, the diagnosis and treatment of this disease are still debatable because of the clinical heterogeneity and the absence of studies including a large number [...] Read more.
Introduction: Small bowel cancer is very rare; although the incidence of adenocarcinoma and other anatomopathological forms has increased recently, the diagnosis and treatment of this disease are still debatable because of the clinical heterogeneity and the absence of studies including a large number of patients. Materials and Methods: We performed a retrospective study over 10 years in which we analyzed the clinical, imaging, and anatomopathological data of 46 patients hospitalized in a surgery clinic and diagnosed with small bowel cancer (duodenum, jejunum, and ileum). Results: After clinical assessment of these patients, including complications (occlusion, bleeding, and perforation), the CT scan established the diagnosis in over 90% of the cases of the complicated form of the disease. Surgery has a curative role in localized cancers; tumor location, local invasion, the presence of locoregional lymph nodes, and the number of multiple tumors influence the type of surgery. The conventional pathological exam was completed via immunohistochemical staining. Adjuvant oncological treatment was performed after surgery (according to the guidelines); in patients with exceptional histopathological forms, the therapy was personalized. Conclusions: Most small bowel cancers were diagnosed with complications (occlusion and bleeding); the tumor type, location, and presence of multiple bowel cancers significantly influenced its management. Independently of the surgical resection (R0/R1 or R2), the prognosis of the disease depends on the tumor aggressivity, location (single/multiple), and locoregional node invasion. Full article
(This article belongs to the Special Issue Histopathology and Diagnosis of Gastrointestinal Tumors)
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16 pages, 3544 KiB  
Article
Local Invasion Patterns Characterized by SARIFA and Tumor Budding Differ and Have Distinct Prognostic Significance in Esophageal Adenocarcinoma and Squamous Cell Carcinoma
by Ákos Jakab, Levente Zarándy, Ildikó Kocsmár, Tibor Várkonyi, István Kenessey, Attila Szijártó, András Kiss, Tamás Vass, Gábor Lotz and Éva Kocsmár
Cancers 2024, 16(18), 3144; https://doi.org/10.3390/cancers16183144 - 13 Sep 2024
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Abstract
Both esophageal squamous cell carcinoma (ESQCC) and adenocarcinoma (EAC) are known to have poor prognosis. We aimed to investigate the invasion front areas of 57 ESQCC and 43 EAC cases to find histological signs of metastatic progression. Tumor cell clusters with different cell [...] Read more.
Both esophageal squamous cell carcinoma (ESQCC) and adenocarcinoma (EAC) are known to have poor prognosis. We aimed to investigate the invasion front areas of 57 ESQCC and 43 EAC cases to find histological signs of metastatic progression. Tumor cell clusters with different cell counts, including tumor buds (TBs) and poorly differentiated clusters (PDCs), were assessed. The presence of the recently described Stroma AReactive Invasion Front Area (SARIFA) phenomenon, which defines a direct contact between tumor cells and adipocytes, was more frequently observed in EAC than in ESQCC (p = 0.004). In adenocarcinomas, a higher prevalence of SARIFA was observed in tumors with a higher number of small clusters (TBs and small PDCs; p < 0.001); furthermore, both the high number of TBs (p = 0.016) and the presence of SARIFA (p = 0.001) correlated with a higher pT stage. SARIFA positivity in EAC (p = 0.011) and high TB in ESQCC (p = 0.0006) were found to be independent prognostic factors for lymph node metastases. Moreover, in ESQCC, the higher absolute number of both TBs and PDCs was associated with shorter overall survival (p = 0.0269 and p = 0.0377, respectively). Our results suggest that the histological subtypes of esophageal cancer behave differently, namely, that different features of the invasion front are of prognostic significance. Full article
(This article belongs to the Special Issue Histopathology and Diagnosis of Gastrointestinal Tumors)
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