Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.3
2.5
Journals
Applied Sciences
Special Issues
Recent Advances in Bioreactor System: Design, Operation and Application
applsci-logo
Submit to Applied Sciences Review for Applied Sciences Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Recent Advances in Bioreactor System: Design, Operation and Application

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 July 2024) | Viewed by 9928

Special Issue Editor

Prof. Dr. Łukasz Kuźma

E-Mail Website
Guest Editor
Department of Biology and Pharmaceutical Botany, Chair of Biology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
Interests: phytochemical analysis; secondary metabolites isolation; chromatographical methods; medicinal plant biotechnology, bioreactors for medicinal plant cultivation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioreactors are a vital tool in bioprocessing, providing a controlled environment for the growth of living cells of microorganisms, plants and fungi, thus enabling efficient and precise bioprocessing. The utilization of bioreactors leads to the establishment of effective control parameters for cell growth and valuable secondary metabolite biosynthesis. Utilizing culture in a bioreactor may also be a crucial step in the production of biomass and valuable natural compounds, from a laboratory to a semi-industrial and even industrial-scale process. Therefore, this Special Issue aims to present new data and experimental results both in the field of new bioreactor systems/prototypes, as well as known constructions used for novel, scientifically unexplored species of microorganisms, fungi and plants; this is particularly with regard to the production of high-efficiency biomass and the biosynthesis of valuable natural compounds . This Special Issue will publish high-quality, original scientific papers that provide new data on bioreactor cultures with a focus on novel, more efficient scalable bioprocessing systems.

Prof. Dr. Łukasz Kuźma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural compounds
  • bioreactor cultures
  • quantitative determination of the natural products
  • biotechnological investigations

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

10 pages, 3184 KiB  
Article
Biomass and Phenolic Acid Accumulation in Salvia austriaca Hairy Roots Grown in Temporary Immersion and Mist-Trickling Bioreactors
by Łukasz Kuźma, Anna Karolina Kiss, Ireneusz Pieszyński, Dymitr Mojsiejew, Justyna Pękala and Jadwiga Nowak
Appl. Sci. 2024, 14(21), 9827; https://doi.org/10.3390/app14219827 - 28 Oct 2024
Viewed by 615
Abstract
Transformed roots of Salvia austriaca were cultivated for 45 days in various systems, including Erlenmeyer flasks, a temporary immersion system (TIS) bioreactor, and a mist-trickling bioreactor, under controlled light conditions. The mist-trickling bioreactor yielded the highest biomass, with fresh and dry weights of [...] Read more.
Transformed roots of Salvia austriaca were cultivated for 45 days in various systems, including Erlenmeyer flasks, a temporary immersion system (TIS) bioreactor, and a mist-trickling bioreactor, under controlled light conditions. The mist-trickling bioreactor yielded the highest biomass, with fresh and dry weights of 155.4 g/L and 10.2 g/L, respectively. Quantitative UHPLC analysis of hydromethanolic extracts revealed the biosynthesis of significant phenolic acids: caffeic acid, rosmarinic acid, and salvianolic acid A. Among these, rosmarinic acid was the most abundant, with its concentration varying based on the cultivation system. The highest total phenolic acid content, 165 mg/L, was obtained in the mist-trickling bioreactor, demonstrating its superiority in both biomass production and phenolic acid biosynthesis. This study highlights the potential of mist-trickling bioreactors for optimizing growth and metabolite production in S. austriaca transformed root cultures. Full article
(This article belongs to the Special Issue Recent Advances in Bioreactor System: Design, Operation and Application)
►▼ Show Figures

Figure 1

20 pages, 2961 KiB  
Article
Mathematical Evaluation of Direct and Inverse Problem Applied in Breakthrough Models of Metal Adsorption
by Wilhamis Fonseca Soeiro, Carlos Henrique Rodrigues Moura, Camila Santana Dias, Emerson Cardoso Rodrigues, Deibson Silva Da Costa, Bruno Marques Viegas and Diego Cardoso Estumano
Appl. Sci. 2024, 14(12), 5035; https://doi.org/10.3390/app14125035 - 10 Jun 2024
Cited by 2 | Viewed by 1100
Abstract
The treatment of industrial effluents has great environmental and human health importance. The purification of water from polluting components, such as metals and organic compounds, can be considered one of the main applications in this field, with adsorption being one of the main [...] Read more.
The treatment of industrial effluents has great environmental and human health importance. The purification of water from polluting components, such as metals and organic compounds, can be considered one of the main applications in this field, with adsorption being one of the main treatment methods. Therefore, with the objective of describing the dynamics of the process in an adsorption column and estimating the parameters involved, in this work, an algorithm for the Method of Lines (MOL) was used in order to numerically solve the model formed by the mass balance in liquid phase, the linear driving force equation (LDF), and the Langmuir isotherm for equilibrium. In addition, a sensitivity analysis of the phenomenon was carried out in relation to the parameters and a subsequent estimation of these was made through the Monte Carlo technique via the Markov chain (MCMC). The validation algorithm was created using data from actual breakthrough curves found in the literature. The experimental data were obtained from the literature for the adsorption of Cadmium (Cd), Copper (Cu), Nickel (Ni), Zinc (Zn), and Chrome (Cr) ions. Among all the estimates, the one that had the lowest adjustment to the data was that related to zinc metal, which had an R2 equal to 0.8984. For the other metals, the correlation coefficient had a value closer to unity. This demonstrates that, in general, the estimates were good enough to represent the dynamics of adsorption. Full article
(This article belongs to the Special Issue Recent Advances in Bioreactor System: Design, Operation and Application)
►▼ Show Figures

Figure 1

18 pages, 7925 KiB  
Communication
GreenTray®, a TIS Bioreactor for Plant Micropropagation and Abiotic or Biotic Stress Bioassays
by Ramon Dolcet-Sanjuan, Maria Casanovas, Sandra Franquesa, Eva Alsina, Francisca Carrasco-Cuello, Estanis Torres, Josep Rufat, Cristina Solsona and Neus Teixido
Appl. Sci. 2024, 14(10), 4051; https://doi.org/10.3390/app14104051 - 10 May 2024
Viewed by 986
Abstract
The temporary immersion system bioreactor named GreenTray® presents advantages over the existing ones. Firstly, there is no need to use forceps to move the shoots or plantlets in or out of the recipient, nor is the use of a scalpel necessary to [...] Read more.
The temporary immersion system bioreactor named GreenTray® presents advantages over the existing ones. Firstly, there is no need to use forceps to move the shoots or plantlets in or out of the recipient, nor is the use of a scalpel necessary to divide them. Secondly, the basis of the shoot can remain in the GreenTray® and can sprout again over several cycles of growth. These two characteristics reduce the costs in the process of micropropagation. In addition, shoot or plantlet development is enhanced by the aeration of the recipient, thus enriching the recipient’s atmospheric CO2. This article describes and provides images and values of interest in (1) the micropropagation process of some commercial Prunus or Pyrus rootstocks; (2) the plantlet growth under autotrophic conditions; and (3) the inoculation of plants with pathogens that reproduce in vitro the symptoms observed in vivo, using the GreenTray® bioreactor. Full article
(This article belongs to the Special Issue Recent Advances in Bioreactor System: Design, Operation and Application)
►▼ Show Figures

Figure 1

14 pages, 1118 KiB  
Article
Use of Bayesian Methods in the Process of Uranium Bioleaching by Acidithiobacillus ferrooxidans
by Altair Costa Cardoso, Camila Santana Dias, Carlos Henrique Rodrigues de Moura, Josiel Lobato Ferreira, Emerson Cardoso Rodrigues, Emanuel Negrão Macêdo, Diego Cardoso Estumano and Bruno Marques Viegas
Appl. Sci. 2024, 14(1), 109; https://doi.org/10.3390/app14010109 - 22 Dec 2023
Cited by 3 | Viewed by 1137
Abstract
This research is focused on investigating the utilization of Bayesian methodologies, specifically the Markov Chain Monte Carlo method, as well as filter sampling by importance and sequential resampling. The objective is to estimate kinetic parameters and state variables associated with the uranium bioleaching [...] Read more.
This research is focused on investigating the utilization of Bayesian methodologies, specifically the Markov Chain Monte Carlo method, as well as filter sampling by importance and sequential resampling. The objective is to estimate kinetic parameters and state variables associated with the uranium bioleaching process by Acidithiobacillus ferrooxidans. Experimental data of cell concentration, uranium concentration, and concentrations of ferrous and ferric ions, obtained from literature, were employed. These measurements were evaluated using a mathematical model expressed by a system of ordinary differential equations. Three different mathematical models were evaluated, considering different uncertainties in experimental measurements and mathematical models (1% and 5%). The estimation results presented a good fit to the experimental data, with coefficients of determination in the range of 0.95 to 0.99. The validation of the mathematical models was obtained by reproducing the experimental measurements and the Bayesian techniques proved to be suitable for application in the bioleaching process. Full article
(This article belongs to the Special Issue Recent Advances in Bioreactor System: Design, Operation and Application)
►▼ Show Figures

Figure 1

Review

Jump to: Research

24 pages, 2436 KiB  
Review
Bioreactors: Applications and Innovations for a Sustainable and Healthy Future—A Critical Review
by Fernanda Palladino, Paulo Ricardo Franco Marcelino, Andersen Escobar Schlogl, Álvaro Henrique Mello José, Rita de Cássia Lacerda Brambilla Rodrigues, Daniela Leite Fabrino, Igor José Boggione Santos and Carlos Augusto Rosa
Appl. Sci. 2024, 14(20), 9346; https://doi.org/10.3390/app14209346 - 14 Oct 2024
Viewed by 3226
Abstract
Biotechnological processes are essential for developing economies that aim to stand out in future markets. The use of bioreactors is one of the most important unit operations of biotechnological processes, and real-time monitoring of bioreactors is essential to ensure precise bioprocess control. This [...] Read more.
Biotechnological processes are essential for developing economies that aim to stand out in future markets. The use of bioreactors is one of the most important unit operations of biotechnological processes, and real-time monitoring of bioreactors is essential to ensure precise bioprocess control. This review presents different types of bioreactors, sensors, and applications in other sectors. Bioreactors, controlled systems for cultivating microorganisms and cells, are essential tools in various fields, from scientific research to industrial production. The use of a variety of sensors is critical for accurate, real-time monitoring, early problem detection, reproducibility, cost reduction, and increased efficiency. These benefits are being realized in numerous applications, including biofuel production, bioremediation and leaching processes, tissue engineering, and drug manufacturing. Innovations in bioreactor technology are expanding opportunities for a more sustainable and healthier future. By developing new types of bioreactors, integrating advanced sensors, and exploring promising applications, bioreactors are playing a key role in addressing global challenges and sustainably advancing science and technology. Full article
(This article belongs to the Special Issue Recent Advances in Bioreactor System: Design, Operation and Application)
►▼ Show Figures

Figure 1

22 pages, 633 KiB  
Review
Exploring Key Parameters in Adsorption for Effective Fluoride Removal: A Comprehensive Review and Engineering Implications
by Letícia Reggiane de Carvalho Costa, Ivone Vanessa Jurado-Davila, Júlia Toffoli De Oliveira, Keila Guerra Pacheco Nunes, Diego Cardoso Estumano, Robson Alves de Oliveira, Elvis Carissimi and Liliana Amaral Féris
Appl. Sci. 2024, 14(5), 2161; https://doi.org/10.3390/app14052161 - 5 Mar 2024
Cited by 9 | Viewed by 2257
Abstract
Water pollution, particularly from elevated fluoride ion (F−) concentrations, is a significant challenge in many developing countries, particularly those relying on groundwater. The stable form of fluoride, F−, poses health risks, leading to concerns about various diseases and harmful [...] Read more.
Water pollution, particularly from elevated fluoride ion (F−) concentrations, is a significant challenge in many developing countries, particularly those relying on groundwater. The stable form of fluoride, F−, poses health risks, leading to concerns about various diseases and harmful effects. Despite global efforts, high F− concentrations (>1.5 mg L−1) persist in numerous countries, requiring effective and sustainable removal methods. Adsorption, known for its simplicity, cost-effectiveness, and efficiency, stands out as a promising technique for F− removal from drinking water. Successful commercial implementation necessitates the optimization of separation conditions. This systematic literature review focuses on the adsorption process for F− removal, exploring parameters such as temperature, adsorbent particle size, pH, adsorbent mass, and co-existing ions for efficient removal. Observations indicate that, despite the utilization of a diverse range of adsorbents, several limitations persist. These include low adsorption capacity, a sluggish adsorption rate, a restricted pH range, and high associated costs. The mechanistic understanding of adsorption and the ongoing development of novel adsorbents remain focal points for future research. Additionally, there is a need to explore alternative kinetic models grounded in statistical factors and give due consideration to thermodynamic studies. Full article
(This article belongs to the Special Issue Recent Advances in Bioreactor System: Design, Operation and Application)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop