Advances in Angiogenesis, Inflammation, and Oxidative Stress in Inflammatory Bowel Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 15 January 2025 | Viewed by 2088

Special Issue Editors


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Guest Editor
Department of Immunology, University of Medicine and Pharmacy, 200349 Craiova, Romania
Interests: pancreatic disorders; polymorphism; genotype; VEGFR-2; vitamin C; ascorbic acid; diabetes mellitus; periodontal disease; antigens; monoclonal antibody; NLRP3; citokines; pro-angiogenic factors; chronic periodontitis; case-control; matrix metalloproteinase; periodontal parameters
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Guest Editor
Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Interests: inflammatory bowel diseases; digestive cancers; endoscopic imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Research over the last few decades has led to the use of biological therapy with human monoclonal antibodies, which has enabled the improved regulation of both the cellular immune response and inflammation of the intestinal mucosa, leading to clinical remission and endoscopic healing. However, there are patients in whom mucosal healing is not observed or alters the natural history of their inflammatory bowel disease.

In light of these observations, in this Special Issue, we will collect important studies (original research or review articles) regarding the evaluation of angiogenic, inflammatory, and oxidative stress in patients with IBD.

Studies investigating the hypothesis that angiogenesis and oxidative stress contribute significantly to mucosal inflammation in IBD are also welcome. Since symptoms are often subjective, and invasive procedures are often a burden for the patient, studying the interrelation between angiogenic factors, inflammatory markers, and oxidative stress factors will enable an objective measurement of disease activity.

Dr. Mihail Virgil Boldeanu
Prof. Dr. Dan Ionuț Gheonea
Guest Editors

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Keywords

  • inflammatory bowel disease
  • angiogenesis
  • inflammation
  • oxidative stress

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Published Papers (2 papers)

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Research

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12 pages, 1822 KiB  
Article
Spasmolytic Activity of 1,3-Disubstituted 3,4-Dihydroisoquinolines
by Miglena Milusheva, Mihaela Stoyanova, Vera Gledacheva, Iliyana Stefanova, Mina Todorova and Stoyanka Nikolova
Biomedicines 2024, 12(7), 1556; https://doi.org/10.3390/biomedicines12071556 - 13 Jul 2024
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Abstract
This article concerns the spasmolytic activities of some novel 1,3-disubstituted 3,4-dihydroisoquinolines. These compounds can be evaluated as potential therapeutic candidates according to Lipinski’s rule of five, showing high gastrointestinal absorption and the ability to cross the blood–brain barrier, which is a very important [...] Read more.
This article concerns the spasmolytic activities of some novel 1,3-disubstituted 3,4-dihydroisoquinolines. These compounds can be evaluated as potential therapeutic candidates according to Lipinski’s rule of five, showing high gastrointestinal absorption and the ability to cross the blood–brain barrier, which is a very important parameter in the drug discovery processes. In silico simulation predicted smooth muscle relaxant activity for all the compounds. Since smooth muscle contractile failure is a characteristic feature of many disorders, in the current paper, we concentrate on the parameters of the spontaneous contractile responses of smooth muscle (SM) cells compared to the well-known drug mebeverine. Two of the newly synthesized substances can be identified as essential modulating regulators and potentially used as therapeutic molecules. One of these molecules also showed significant DPPH antioxidant activity compared to rutin. Full article
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Review

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20 pages, 724 KiB  
Review
Nesfatin-1: A Novel Diagnostic and Prognostic Biomarker in Digestive Diseases
by Adriana-Cezara Damian-Buda, Daniela Maria Matei, Lidia Ciobanu, Dana-Zamfira Damian-Buda, Raluca Maria Pop, Anca Dana Buzoianu and Ioana Corina Bocsan
Biomedicines 2024, 12(8), 1913; https://doi.org/10.3390/biomedicines12081913 - 20 Aug 2024
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Abstract
Nesfatin-1, deriving from a precursor protein, NUCB2, is a newly discovered molecule with anti-apoptotic, anti-inflammatory, antioxidant, and anorexigenic effects. It was initially identified in the central nervous system (CNS) and received increasing interest due to its energy-regulating properties. However, research showed that nesfatin-1 [...] Read more.
Nesfatin-1, deriving from a precursor protein, NUCB2, is a newly discovered molecule with anti-apoptotic, anti-inflammatory, antioxidant, and anorexigenic effects. It was initially identified in the central nervous system (CNS) and received increasing interest due to its energy-regulating properties. However, research showed that nesfatin-1 is also expressed in peripheral tissues, including the digestive system. The aim of this review is to give a résumé of the present state of knowledge regarding its structure, immunolocalization, and potential implications in diseases with inflammatory components. The main objective was to focus on its clinical importance as a diagnostic biomarker and potential therapeutic molecule in a variety of disorders, among which digestive disorders were of particular interest. Previous studies have shown that nesfatin-1 regulates the balance between pro- and antioxidant agents, which makes nesfatin-1 a promising therapeutic agent. Further in-depth research regarding the underlying mechanisms of action is needed for a better understanding of its effects. Full article
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