Pathology and Treatment of Vascular Complications during Pregnancy
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1812
Special Issue Editor
Interests: pancreatic disorders; polymorphism; genotype; VEGFR-2; vitamin C; Ascorbic acid; Diabetes mellitus; periodontal disease; antigens; Monoclonal Antibody; NLRP3; Citokines; Pro-angiogenic factors; chronic periodontitis; case-control; matrix metalloproteinase; periodontal pa-rameters
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Special Issue Information
Dear Colleagues,
Human pregnancy is a complex process. The development of the placenta, for example, is influenced by the molecules secreted by placental trophoblastic cells, as well as by the cells of the immune system in the decidua of the maternal endometrium.
Successful placentation is characterized by an expansion of angiogenesis, essential for improving placental circulation and blood flow with the formation of new vascular beds to allow the growth and vascular development of the placenta.
Placental factors, especially pro-angiogenic and anti-angiogenic proteins, are responsible for placental growth, as well as the vascularization and maintenance of vessel health.
In recent years, evidence has suggested that chronic inflammation, inadequate trophoblast invasion, poor angiogenesis, and the failure of immunological tolerance are co-influential factors in various placental-initiated disorders.
Trophoblast invasion, angiogenesis, and placentation are regulated by the secretion of angiogenesis-regulating molecules, chemokines, and cytokines by phenotypically activated NK cells, T cell subsets, and macrophages.
In this Special Issue, we aim to collect recent knowledge on the study of abnormalities in placental vascular development, and the study of the immunological harmony between mother and fetus, which can lead to various syndromes, such as preeclampsia, premature birth, and intrauterine growth restriction. We will also consider studies addressing the interrelationships between angiogenesis, inflammation, and oxidative stress in pregnancy. Original research articles and reviews are both welcome.
Dr. Mihail Virgil Boldeanu
Guest Editor
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Keywords
- maternal–fetal interface
- placenta
- immune tolerance
- implantation
- decidualization
- angiogenesis
- inflammation
- oxidative stress
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