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Biomedicines
Special Issues
Bioactive Compounds in Chronic Diseases—2nd Edition
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Bioactive Compounds in Chronic Diseases—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2328

Special Issue Editor

Prof. Dr. Vasso Apostolopoulos

E-Mail Website
Guest Editor
Institute for Health and Sport, Victoria University, Melbourne, VIC 3011, Australia
Interests: immunology; protein crystallography; medicinal chemistry; cellular and molecular biology; extensive translational research; clinical trials; vaccines; drugs; healthy ageing; chronic diseases; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive compounds can be derived from natural products, animal products, and plants, and can be synthetically produced. They have gained widespread attention in recent years as they have shown to be effective in a number of chronic and infectious diseases, such as cancer, cardiovascular disease, diabetes, autoimmune disorders, and infectious diseases. In addition, their use can promote better health. As such, vitamins, minerals, herbal, polyphenols, pre- and pro-biotics, natural products, nutritional therapies, and cannabis therapies have been shown to boost the immune system, consequently helping to manage and treat disease. This Special Issue will focus on natural and bioactive treatments used to overcome or manage chronic and infectious diseases, including in vitro, animal in vivo, and human clinical studies.

Prof. Dr. Vasso Apostolopoulos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alkaloids
  • anthocyanidin
  • apigenin
  • bioactives
  • caffeine
  • carotenoids
  • carnosine
  • cereals
  • choline
  • coenzyme Q
  • creatine
  • curcumin
  • dietary fiber
  • fatty acids
  • fermented milk
  • gallic acid
  • glucosinolates
  • glycomacropeptide
  • grains
  • flavan
  • flavanone
  • flavones
  • isoflavones
  • lactoferrin
  • lutein
  • lignan
  • linoleic acid
  • lycopene
  • milk
  • minerals
  • natural products
  • omega-3 fatty acids
  • omega-6 fatty acids
  • polyphenol
  • phenolic acid
  • phenols
  • phytosterols
  • prebiotics
  • probiotics
  • quercetin
  • resveratrol
  • saponin
  • sprouts
  • tannin
  • tea
  • terpenes
  • terpenoids
  • tocopherols
  • polysaccharides
  • phytochemistry
  • phytoestrogens
  • proanthocyanidin
  • procyanidin
  • rutin
  • vitamin B
  • vitamin C
  • vitamin D
  • vitamin E
  • zeanxanthin

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Related Special Issue

Published Papers (2 papers)

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Research

19 pages, 1996 KiB  
Article
Ethanolic Extract of Salvia officinalis Leaves Affects Viability, Survival, Migration, and the Formation and Growth of 3D Cultures of the Tumourigenic Murine HPV-16+-Related Cancer Cell Line
by Alejandra E. Hernández-Rangel, Ariana Cabrera-Licona, Gustavo A. Hernandez-Fuentes, Oscar F. Beas-Guzmán, Francisco J. Martínez-Martínez, Mario A. Alcalá-Pérez, Daniel A. Montes-Galindo, Iram P. Rodriguez-Sanchez, Margarita L. Martinez-Fierro, Juan C. Casarez-Price, Luis De-Leon-Zaragoza, Idalia Garza-Veloz and Iván Delgado-Enciso
Biomedicines 2024, 12(8), 1804; https://doi.org/10.3390/biomedicines12081804 - 8 Aug 2024
Viewed by 1078
Abstract
Salvia officinalis (SO) is one of the most widely used plants in traditional medicine worldwide. In the present study, the effect of an ethanolic extract of S. officinalis leaves on hallmarks of cancer of HPV-16-positive cancer tumorigenic cells, TC-1, was analyzed in vitro. [...] Read more.
Salvia officinalis (SO) is one of the most widely used plants in traditional medicine worldwide. In the present study, the effect of an ethanolic extract of S. officinalis leaves on hallmarks of cancer of HPV-16-positive cancer tumorigenic cells, TC-1, was analyzed in vitro. Phytochemical and spectroscopic analysis were performed. Additionally, the extract’s flavonoid content, reducing iron, and antioxidant capacity were determined. In regard to the in vitro tests, the cytotoxic activity and its effect on the replicative capacity and on the cell migration of TC-1 cells were analyzed by viability and clonogenic, survival, and wound healing assays. The effect of a pre-treatment or treatment on 3D culture formation, growth, and reversion capacity was also examined. The results of the phytochemical analysis allowed the detection of tannins, saponins, steroids, and flavonoids. The flavonoids content was found to be 153.40 ± 10.68 µg/mg of extract. Additionally, the extract exhibited an antioxidant capacity and a ferric-reducing capacity of around 40% compared to the ascorbic acid. Thin layer chromatographic (TLC) analysis and spectroscopic tests showed the presence of compounds similar to quercetin and catechin flavonoids in the extract. In the in vitro assays, the SO extract induced in a concentration-dependent way changes in cell morphology, the decrease of cell viability, survival, and migration. At a concentration of 125 µg/mL, the extract inhibited spheroid formation, reduced their growth, and affected their reversion to 2D. Ethanolic extract of S. officinalis leaves had inhibitory effects on hallmarks of the cancer line HPV-16+. This suggests that the phytochemicals present in it may be a source of chemotherapeutics against cervical cancer. Full article
(This article belongs to the Special Issue Bioactive Compounds in Chronic Diseases—2nd Edition)
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15 pages, 3251 KiB  
Article
Eugenol: A Potential Modulator of Human Platelet Activation and Mouse Mesenteric Vascular Thrombosis via an Innovative cPLA2-NF-κB Signaling Axis
by Yi Chang, Chih-Wei Hsia, Kuan-Rau Chiou, Ting-Lin Yen, Thanasekaran Jayakumar, Joen-Rong Sheu and Wei-Chieh Huang
Biomedicines 2024, 12(8), 1689; https://doi.org/10.3390/biomedicines12081689 - 29 Jul 2024
Viewed by 825
Abstract
Background: Platelets, a type of anucleated cell, play a crucial role in cardiovascular diseases (CVDs). Therefore, targeting platelet activation is essential for mitigating CVDs. Endogenous agonists, such as collagen, activate platelets by initiating signal transduction through specific platelet receptors, leading to platelet aggregation. [...] Read more.
Background: Platelets, a type of anucleated cell, play a crucial role in cardiovascular diseases (CVDs). Therefore, targeting platelet activation is essential for mitigating CVDs. Endogenous agonists, such as collagen, activate platelets by initiating signal transduction through specific platelet receptors, leading to platelet aggregation. Eugenol, primarily sourced from clove oil, is known for its antibacterial, anticancer, and anti-inflammatory properties, making it a valuable medicinal agent. In our previous study, eugenol was shown to inhibit platelet aggregation induced by collagen and arachidonic acid. We concluded that eugenol exerts a potent inhibitory effect on platelet activation by targeting the PLCγ2–PKC and cPLA2-TxA2 pathways, thereby suppressing platelet aggregation. In our current study, we found that eugenol significantly inhibits NF-κB activation. This led us to investigate the relationship between the NF-κB and cPLA2 pathways to elucidate how eugenol suppresses platelet activation. Methods: In this study, we prepared platelet suspensions from the blood of healthy human donors to evaluate the inhibitory mechanisms of eugenol on platelet activation. We utilized immunoblotting and confocal microscopy to analyze these mechanisms in detail. Additionally, we assessed the anti-thrombotic effect of eugenol by observing fluorescein-induced platelet plug formation in the mesenteric microvessels of mice. Results: For immunoblotting and confocal microscopy studies, eugenol significantly inhibited NF-κB-mediated signaling events stimulated by collagen in human platelets. Specifically, it reduced the phosphorylation of IKK and p65 and prevented the degradation of IκBα. Additionally, CAY10502, a cPLA2 inhibitor, significantly reduced NF-κB-mediated signaling events. In contrast, BAY11-7082, an IKK inhibitor, did not affect collagen-stimulated cPLA2 phosphorylation. These findings suggest that cPLA2 acts as an upstream regulator of NF-κB activation during platelet activation. Furthermore, both BAY11-7082 and CAY10502 significantly reduced the collagen-induced rise in intracellular calcium levels. In the animal study, eugenol demonstrated potential as an anti-thrombotic agent by significantly reducing platelet plug formation in fluorescein-irradiated mouse mesenteric microvessels. Conclusion: Our study uncovered a novel pathway in platelet activation involving the cPLA2-NF-κB axis, which plays a key role in the antiplatelet effects of eugenol. These findings suggest that eugenol could serve as a valuable and potent prophylactic or therapeutic option for arterial thrombosis. Full article
(This article belongs to the Special Issue Bioactive Compounds in Chronic Diseases—2nd Edition)
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