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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Iron Metabolism Rewiring and Ferroptosis to Trigger Drug Resistance in Human Cancers

edited by Anna Martina Battaglia

submission deadline 31 May 2025 | 1 articles | Viewed by 1622 | Submission Open

Keywords: ferroptosis; iron metabolism; reactive oxygen species; resistance mechanisms; iron compound; ferroptosis inducer

(This special issue belongs to the Section Molecular and Translational Medicine)

New Insights in Gastric, Colorectal, and Pancreatic Cancer

edited by

John K. Triantafillidis

submission deadline 31 May 2025 | 1 articles | Viewed by 1188 | Submission Open

Keywords: gastric cancer ; colorectal cancer ; pancreatic cancer; immunotherapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Lipogenesis and Lipolysis: Insights from Molecular Perspectives

edited by

Miran Jang

submission deadline 31 May 2025 | 1 articles | Viewed by 1011 | Submission Open

Keywords: lipogenesis; lipolysis; fat metabolism

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Upper Respiratory Infection: From Pathology to Novel Therapeutic Approaches

edited by Puya Dehgani-Mobaraki

submission deadline 31 May 2025 | 1 articles | Viewed by 722 | Submission Open

Keywords: upper respiratory infections (URIs); rhinology; biological therapies; nasal polyposis; chronic rhinosinusitis; allergic rhinitis; endoscopic sinus surgery; monoclonal antibodies; pharmacological innovations

(This special issue belongs to the Section Molecular and Translational Medicine)

Current Trends in Regenerative Medicine

edited by

Leonidas Kandilogiannakis

and

Eirini Filidou

submission deadline 31 May 2025 | Viewed by 443 | Submission Open

Keywords: regenerative medicine; stem cells; organoids; tissue engineering; gene therapy; cell therapy; biomaterials; personalized medicine

(This special issue belongs to the Section Gene and Cell Therapy)

Recent Therapeutic Advances in Parkinson’s Disease

edited by

Chieh-Sen Chuang

submission deadline 31 May 2025 | Viewed by 434 | Submission Open

Keywords: Parkinson's disease; disease-modifying therapy; continuous dopaminergic stimulation; non-dopaminergic drugs; deep brain stimulation; drug repurposing; immunotherapies; gene therapies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Neonatal Disease: From Pathophysiology to Current and Emerging Therapeutic Approaches (2nd Edition)

edited by

Fumihiko Namba

submission deadline 31 May 2025 | Viewed by 345 | Submission Open

Keywords: fetal therapy; neonatal diseases; pathophysiology; innovative therapeutic approaches

(This special issue belongs to the Section Cell Biology and Pathology)

Colorectal Cancer: Diagnostic, Pathophysiology and Therapeutic Approaches

edited by

Antonio Biondi

and

Marco Vacante

submission deadline 31 May 2025 | Viewed by 306 | Submission Open

Keywords: colorectal cancer; biomarkers; chemotherapy; immunotherapy; liquid biopsy; endoscopy; surgery; microbiota; screening

(This special issue belongs to the Section Cancer Biology and Oncology)

CDK Inhibitors: A New Wave of Therapeutic Agents for Human Diseases

edited by Mengqian Chen

submission deadline 31 May 2025 | Viewed by 266 | Submission Open

Keywords: cyclin-dependent kinases (CDKs); cell-cycle CDKs; transcriptional CDKs; CDK inhibitors; CDK degraders; cancer therapeutics; inflammatory diseases; neurodegenerative disorders; pharmacology; clinical trials

(This special issue belongs to the Section Cancer Biology and Oncology)

The Interplay between miRNA and Mitochondrial Dysfunction in Neurodegenerative Diseases

edited by

Mariano Catanesi

submission deadline 31 May 2025 | Viewed by 200 | Submission Open

Keywords: miRNA; neurodegenerative diseases; mitochondrial dysfunction; aging; gene expression

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Neglected Infectious Diseases: From Pathophysiology to Therapy

edited by Raimunda Nonata Ribeiro Sampaio

submission deadline 31 May 2025 | Viewed by 185 | Submission Open

Keywords: pathophysiology; host– parasite infection interactions; diagnostic tools; therapeutic intervention; novel biomarkers

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Liver Disease: Etiology, Pathology, and Treatment

edited by Ivana Mikolašević

submission deadline 31 May 2025 | Viewed by 136 | Submission Open

Keywords: chronic liver disease; metabolic-associated fatty liver disease; liver fibrosis; liver injury; etiology; pathology; molecular and cellular mechanisms; biomarkers and therapeutic targets; immunotherapy; prevention and treatment

(This special issue belongs to the Section Cell Biology and Pathology)

State-of-the-Art Endocrinology and Metabolism Research in Spain

edited by Zaida Abad-Jiménez and

Teresa Vezza

submission deadline 31 May 2025 | Viewed by 100 | Submission Open

Keywords: endocrinology; metabolism; hormonal regulation; metabolic disorders; biomarkers; therapeutic targets

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Prostate Cancer: From Pathology to Novel Therapeutic Approaches (2nd Edition)

edited by

Gvantsa Kharaishvili

submission deadline 31 May 2025 | Viewed by 87 | Submission Open

Keywords: prostate cancer; castration-resistant prostate cancer; metastatic disease; biomarker; tumor microenvironment; treatment; immunotherapy; drug resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Retinal Diseases: Pathogenetic, Diagnostic and Therapeutic Perspectives

edited by

Irini P. Chatziralli

and Konstantinos Pappelis

submission deadline 31 May 2025 | Viewed by 72 | Submission Open

Keywords: age-related macular degeneration; central serous chorioretinopathy; pachychoroid spectrum; choroidal neovascularization; diabetic retinopathy; retinal vein occlusion; retinal artery occlusion; sickle cell retinopathy; optical coherence tomography; OCT angiography; widefield imaging; anti-VEGF agents

(This special issue belongs to the Section Molecular and Translational Medicine)

Progress in Nanotechnology-Based Therapeutic Strategies

edited by Ambra Del Grosso and Mariacristina Gagliardi

submission deadline 31 May 2025 | Viewed by 69 | Submission Open

Keywords: Nanotechnology-based therapies; Targeted drug delivery; Nanoparticles; Nanostructures; Cancer treatment; Cardiovascular diseases; Neurodegenerative diseases; Infectious diseases; Lysosomal storage disorders; Regenerative medicine; Tissue engineering; Gene therapy; Biochemical diagnostics; Omics approaches; Biological barriers

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Advances in Neurological Diseases: Pathogenesis, Diagnosis and Therapeutic Strategies

edited by

Foteini Christidi

and

Dimitrios Tsiptsios

submission deadline 31 May 2025 | Viewed by 68 | Submission Open

Keywords: neurological diseases; neurodegenerative diseases; stroke; multiple sclerosis; epilepsy; neuromuscular disorders; demyelinating diseases; traumatic brain injury; clinical neurophysiology; neuroimaging; genetics; neuropsychological tests; molecular and cellular mechanisms; biomarkers; diagnosis and therapeutics; prognosis; neurorehabilitation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Hypertension and Chronic Renal Failure

edited by Caterina Carollo

submission deadline 31 May 2025 | Viewed by 61 | Submission Open

Keywords: hypertension; chronic renal failure; NephroCardiology

(This special issue belongs to the Section Molecular and Translational Medicine)

Infectious Diseases: Prevention, Diagnosis, and Treatment Under Antimicrobial Resistance Global Urgency

edited by

Célia F. Rodrigues

submission deadline 31 May 2025 | Viewed by 60 | Submission Open

Keywords: AMR; infectious diseases; bacteria; fungi; alternative treatment

(This special issue belongs to the Section Microbiology in Human Health and Disease)

New Imaging Strategies for Organoids

edited by

Wolfgang J. Weninger

and

Stefan H. Geyer

submission deadline 31 May 2025 | Viewed by 53 | Submission Open

Keywords: imaging; organoids; 3D imaging; volumetry; characterisation

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in Epilepsy Research

edited by Duyu A. Nie

submission deadline 31 May 2025 | Viewed by 41 | Submission Open

Keywords: disease mechanisms; genetics; biomarkers; epilepsy surgery; electroencephalogram; animal models; artificial intelligence

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Pathogenesis, Diagnostics and Therapeutics in Obsterics and Gynaecology

edited by

Nikolaos Machairiotis

submission deadline 31 May 2025 | Viewed by 41 | Submission Open

Keywords: gynaecology; obstetrics; diagnosis; pathogenesis; treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Feature Reviews in Gastrointestinal Diseases

edited by

Fu-Chen Huang

submission deadline 31 May 2025 | Viewed by 38 | Submission Open

Keywords: precision medicine; artificial intelligence; eosinophilic gastrointestinal diseases; inflammatory bowel disease; irritable bowel syndrome; gastroesophageal reflux disease; gastrointestinal cancers; drug-resistant infections

(This special issue belongs to the Section Molecular and Translational Medicine)

Neurovascular Dysfunction: Mechanisms and Therapeutic Strategies

edited by

Deepti Diwan

submission deadline 31 May 2025 | Viewed by 33 | Submission Open

Keywords: neurovascular; blood vessels; nervous system; neurological diseases

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Parkinson’s Disease: Where Are We and Where Are We Going To

edited by Carmen Borrué

submission deadline 31 May 2025 | Viewed by 25 | Submission Open

Keywords: Parkinson’ s disease; gait disorders; biomarkers; neurodegenerative disease; AI

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Medicinal Chemistry in Drug Design and Discovery, 2nd Edition

edited by

Małgorzata Jarończyk

submission deadline 31 May 2025 | Viewed by 23 | Submission Open

Keywords: design and synthesis of medicinal compounds; identification and characteristics of targets; mechanism of action; profiles of safety; structure– activity relationship; ligand– target interactions; drugs repurposing

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advanced Research on Genitourinary Cancer

edited by Jue Wang

submission deadline 31 May 2025 | Viewed by 23 | Submission Open

Keywords: genitourinary (GU) cancer; prostate; bladder; kidney; and testicular cancer; diagnosis; treatment; pathogenesis; precision medicine; biomarker discovery; genomic profiling

(This special issue belongs to the Section Molecular and Translational Medicine)

From Pathophysiology to Novel Therapeutic Approaches in Alzheimer’s Disease

edited by

Lorenzo Falsetti

submission deadline 31 May 2025 | Viewed by 20 | Submission Open

Keywords: Alzheimer's disease; neurodegeneration; cognitive deterioration; dementia

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances of Autophagy in Human Cancers and Tumors

edited by Po-Hsiang Liao

submission deadline 31 May 2025 | Viewed by 12 | Submission Open

Keywords: autophagy; chemoresistance; chaperone-mediated autophagy (CMA); clockophagy; ferritinophagy

(This special issue belongs to the Section Cancer Biology and Oncology)

Novel Biomarker and Treatments for Diabetic Neuropathy

edited by Arun V. Krishnan and Tushar Issar

submission deadline 31 May 2025 | Viewed by 8 | Submission Open

Keywords: diabetic peripheral neuropathy; type 1 diabetes; type 2 diabetes; glucagon-like peptide-1 receptor agonists; metabolic syndrome; in vivo corneal confocal microscopy; nerve ultrasonography; obesity; exercise

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Clinical, Radiological, and Molecular Insights into Craniopharyngioma

edited by Ernest Jan Bobeff and

Bartosz Szmyd

submission deadline 31 May 2025 | Viewed by 6 | Submission Open

Keywords: neuro-oncology; brain tumors; skull base; craniopharyngioma; stalk

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Recent Advances in Targeted Drug Delivery Systems

edited by

Santosh Bashyal

submission deadline 31 May 2025 | Viewed by 4 | Submission Open

Keywords: targeted drug delivery systems; nanocarriers (lipid or polymeric); stimuli-responsive carriers; exosomes or exosome-mimetic vesicles; disease targeting; tumor targeting; theranostics

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Feature Reviews in Cancer Genetics and Epigenetics

edited by

Zheng-Yuan Su

submission deadline 31 May 2025 | Submission Open

Keywords: cancer genetics; epigenetics; DNA methylation; histone modifications; non-coding RNAs; tumor heterogeneity; drug resistance; biomarkers; precision oncology; personalized therapy

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Ophthalmic Genetics: Unraveling the Genomics of Eye Disorders

edited by Raffaella Cascella

submission deadline 31 May 2025 | Submission Open

Keywords: ophthalmic genetics; inherited retinal disease; genomics; molecular biology; gene therapy; artificial intelligence; bioinformatics; biostatistical analysis

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

New Advances in Insulin—100 Years Since Its Discovery: 2nd Edition

edited by

Tomislav Bulum

submission deadline 31 May 2025 | Submission Open

Keywords: insulin action; insulin analogs; type 1 diabetes; type 2 diabetes; complications; glucose homeostasis

(This special issue belongs to the Section Cell Biology and Pathology)

Advancements in Cardiac Imaging: Diagnostics, Prognostics, and Therapeutics

edited by Ilaria Dentamaro

submission deadline 31 May 2025 | Submission Open

Keywords: cardiac imaging; echocardiography; cardiovascular magnetic resonance imaging; cardio CT; nuclear cardiology

(This special issue belongs to the Section Molecular and Translational Medicine)

Brain Injury: New Insights into Mechanisms and Future Promising Treatments—Second Edition

edited by

Kristina Pilipović

and

Petra Dolenec

submission deadline 31 May 2025 | Submission Open

Keywords: acquired brain injury; nanomedicine; nanotechnology; neuroregenerative therapy; neurorepair; new and emerging treatments; pharmacotherapy; stroke; tissue engineering; traumatic brain injury

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Spinal Muscular Atrophy: Pathogenesis, Diagnosis, Therapeutics and Future Directions

edited by

Dinko Vitezić

Andrej Belančić

and Valentino Rački

submission deadline 1 Jun 2025 | Viewed by 50 | Submission Open

Keywords: genetic diseases; neuromuscular disorders; rare diseases; spinal muscular atrophy; survival motor neuron protein

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Peptides and Amino Acids in Drug Development: Here and Now

edited by

Siva Panda

submission deadline 6 Jun 2025 | 3 articles | Viewed by 5707 | Submission Open

Keywords: peptide chemistry; amino acids; drug conjugates; drug development; drug delivery; coupling reagents; peptidomimetics; cyclic peptides; peptide ligation

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Antioxidant and Antimicrobial Potencies of Biomolecule

edited by

Vinit Raj

submission deadline 11 Jun 2025 | 3 articles | Viewed by 7369 | Submission Open

Keywords: biomolecules; metabolomics; oxidative stress levels; polymer; microorganisms; nanotechnology

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Neurodegenerative Diseases: Recent Advances and Future Perspectives—Volume II

edited by

Inés López-Cuenca

and

Rosa De Hoz

submission deadline 25 Jun 2025 | Viewed by 202 | Submission Open

Keywords: neurodegeneration; neuroprotection; dementia; Parkinson’ s disease

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Emerging Insights into HIV

edited by Konstantinos Protopapas, Antonios Papadopoulos and

Charalampos D. Moschopoulos

submission deadline 30 Jun 2025 | 5 articles | Viewed by 7222 | Submission Open

Keywords: HIV/AIDS; antiretroviral treatment; comorbidities; co-infection; neuroHIV

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Emerging Trends in Dental Caries: Insights into Etiology, Risk Factors, and Treatment Strategies

edited by

Hee-Eun Kim

submission deadline 30 Jun 2025 | 5 articles | Viewed by 5098 | Submission Open

Keywords: antimicrobial effect; demineralization; dental caries; dental plaque; oral biofilm; oral disease; oral management; pathogenicity; prevention; remineralization

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Mechanisms of Cell Death in Cancer Cells: A New Therapeutic Opportunity—2nd Edition

edited by

Adrian-Bogdan Țigu

submission deadline 30 Jun 2025 | 3 articles | Viewed by 4307 | Submission Open

Keywords: cell death; drug repositioning; translational research; oncology; cancer therapy; apoptosis

(This special issue belongs to the Section Cell Biology and Pathology)

Progress in Antiretroviral Research

edited by Massimiliano Lanzafame

submission deadline 30 Jun 2025 | 1 articles | Viewed by 602 | Submission Open

Keywords: antiretroviral therapy; short cycle therapy; HIV infection; long-acting agents

(This special issue belongs to the Section Cell Biology and Pathology)

Antioxidant Materials with Additional Biological Properties

edited by

Nurettin Sahiner

submission deadline 30 Jun 2025 | Viewed by 259 | Submission Open

Keywords: natural antioxidants; flavonoids; and polyphenols; biocompatible and blood compatible; hydrogel; microgels; nanogel; and particles; polymeric particles; carbon quantum dots; and g-C3N4; stimuli-responsive materials; drug delivery systems; controlled release; and targeted delivery/therapies; antibacterial; antifungal; antiviral; anticancer; and biocidal; ROS-scavenging activity; proteins; enzyme; peptides; and amino acids; activate-able materials and photodynamic therapy

(This special issue belongs to the Section Biomedical Engineering and Materials)

Progress in Protein Therapeutics

edited by Iman Tavassoly

submission deadline 30 Jun 2025 | Viewed by 206 | Submission Open

Keywords: biologics; monoclonal antibodies; recombinant proteins; therapeutic peptides; protein engineering; protein therapeutics

(This special issue belongs to the Section Gene and Cell Therapy)

Exploring Breakthroughs in Intestinal Mucosal Repair and Regeneration

edited by

Lixia He

submission deadline 30 Jun 2025 | Viewed by 200 | Submission Open

Keywords: intestinal mucosal repair; inflammatory bowel disease (IBD); stem cell regeneration; gut microbiota and healing; tissue engineering in gastroenterology; nutritional therapy for mucosal health; biomarkers of mucosal damage; novel therapeutic interventions; mucosal immunology; epithelial barrier function

(This special issue belongs to the Section Immunology and Immunotherapy)

Mechanisms and Therapeutic Strategies of Brain and Spinal Cord Injury

edited by

Hatice Kumru

and Xabier Urra

submission deadline 30 Jun 2025 | Viewed by 157 | Submission Open

Keywords: brain injury; spinal cord injury; stem cells; gene therapy; neuromodulation techniques

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Current Aspects on the Therapeutics of Aging, Cellular Senescence and Neurodegenerative Diseases

edited by

Ashok Iyaswamy

submission deadline 30 Jun 2025 | Viewed by 144 | Submission Open

Keywords: therapeutics; neurodegenerative diseases; aging; cellular senescence; Alzheimer’ s disease; Parkinson’ s disease

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

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