Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathophysiology of Fatty Acid Metabolism submission deadline 30 Apr 2025 | Viewed by 181 | Submission Open
Keywords: fatty acids; signalling molecules; gene expression; metabolic disorders
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Biomarkers for Neurodegenerative Disorders: From Bench to Bedside
edited by George P. Paraskevas
submission deadline 30 Apr 2025 | Viewed by 167 | Submission Open
Keywords: dementia; Alzheimer’ s disease; frontotemporal dementia; dementia with Lewy bodies; parkinsonism; tau protein; TDP-43; α -synuclein; Tau-PET; amyloid-PET
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Mechanomedicine: Exploring Mechanobiology at the Intersection of Engineering and Biology
edited by
submission deadline 30 Apr 2025 | Viewed by 162 | Submission Open
Keywords: mechanomedicine; mechanobiology; microphysiological systems; bioengineering; forces
(This special issue belongs to the Section Biomedical Engineering and Materials)
Diabetes: Comorbidities, Therapeutics and Insights (2nd Edition)
edited by
submission deadline 30 Apr 2025 | Viewed by 159 | Submission Open
Keywords: diabetes; complications; diabetic retinopathy; diabetic neuropathy; diabetic nephropathy; biomarkers
(This special issue belongs to the Section Molecular and Translational Medicine)
Acute and Chronic Heart Failure: Pathophysiology and New Therapeutic Developments, 2nd Edition
edited by and Valentina Mercurio
submission deadline 30 Apr 2025 | Viewed by 145 | Submission Open
Keywords: heart failure with reduced ejection fraction; heart failure with preserved ejection fraction; pathophysiological novelties; treatment advances; pulmonary arterial hypertension; at-home follow-up of patients with heart failure
(This special issue belongs to the Section Molecular and Translational Medicine)
Novel Approaches for Diagnosis and Treatment of Pancreatic Cancer submission deadline 30 Apr 2025 | Viewed by 143 | Submission Open
Keywords: pancreatic cancer; small molecules; monoclonal antibodies; antibody-drug conjugated; personalized therapy; immunotherapy; natural compounds; exosomes; nanoparticles; biomarkers
(This special issue belongs to the Section Cancer Biology and Oncology)
Molecular Mechanisms of Normal and Malignant Hematopoiesis: 2nd Edition
edited by
submission deadline 30 Apr 2025 | Viewed by 132 | Submission Open
Keywords: hematopoietic stem cells; self-renewal; differentiation; hematological malignancies; molecular mechanisms; genetic factors; epigenetic factors; transcriptional regulation; HSC niche; targeted therapy
(This special issue belongs to the Section Molecular and Translational Medicine)
Pathogenesis, Diagnosis and Treatment of Hematologic Malignancies
edited by
submission deadline 30 Apr 2025 | Viewed by 129 | Submission Open
Keywords: hematologic malignancies; pathogenesis; diagnosis; treatment; targeted therapy; molecular research
(This special issue belongs to the Section Molecular and Translational Medicine)
MicroRNA and Its Role in Human Health, 2nd Edition
edited by
submission deadline 30 Apr 2025 | Viewed by 112 | Submission Open
Keywords: microRNA; disease models; disease associations; molecular mechanism; molecular diagnosis; molecular therapy
(This special issue belongs to the Section Cell Biology and Pathology)
New Advances in Cardiovascular Drugs: In Memory of Professor Akira Endo
edited by
submission deadline 30 Apr 2025 | Viewed by 99 | Submission Open
Keywords: cardiovascular drugs; statins; metformin; SGLT2i; laboratory; drug targets; translational research; targeted therapy
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Feature Reviews in Drug Design and Drug Development
edited by
submission deadline 30 Apr 2025 | Viewed by 87 | Submission Open
Keywords: antimicrobial resistance; drug design; cancer therapeutics vaccine development; biomaterials computational modeling; machine learning; therapeutic targets; pharmacokinetics and toxicity
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Epigenetic Regulation and Its Impact for Medicine (2nd Edition)
edited by
submission deadline 30 Apr 2025 | Viewed by 81 | Submission Open
Keywords: gene expression; DNA methylation; histone modifications; non-coding RNAs; biomarkers
(This special issue belongs to the Section Molecular and Translational Medicine)
Role of Stem Cells in Cardiovascular Diseases
edited by Jyotsna Joshi, Junjie Yang and Mallikarjun Patil
submission deadline 30 Apr 2025 | Viewed by 73 | Submission Open
Keywords: stem cells; iPSCs; cardiovascular cells; cell communication; exosomes; miRNAs; cardiac diseases; stem cells therapy; regenerative medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Mechanisms and Novel Treatment Options for Non-Small-Cell Lung Cancer
edited by Catríona M. Dowling
submission deadline 30 Apr 2025 | Viewed by 69 | Submission Open
Keywords: NSCLC; tumor microenvironment; novel therapeutic; biomarkers; resistance; advances in technology; in vitro and ex vivo models
(This special issue belongs to the Section Cancer Biology and Oncology)
Advances in Depression Research: Neurobiology, Models, Biomarkers and Therapies submission deadline 30 Apr 2025 | Viewed by 68 | Submission Open
Keywords: depression; neurobiology; biomarkers; experimental models; antidepressant therapies; personalized medicine; treatment resistance; pharmacology; psychiatric disorders
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Advances in Novel Drug Discovery, Synthesis, and Evaluation
edited by
submission deadline 30 Apr 2025 | Viewed by 64 | Submission Open
Keywords: drug synthesis; novel therapies; disease targets; medicinal chemistry; computational methods; screening techniques; pharmaceutical development; target identification
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Sex Hormones and Cardiovascular Diseases: From Pathophysiology to Novel Therapeutic Approaches submission deadline 30 Apr 2025 | Viewed by 54 | Submission Open
Keywords: endogenous sex hormones; aging; sexual dimorphism; hormone replacement therapy; CVDs; hypertension; myocardial infarction; atherosclerosis
(This special issue belongs to the Section Molecular and Translational Medicine)
Revolutionizing Cancer Treatment: Advances in CAR T and CAR NK Cell Therapies submission deadline 30 Apr 2025 | Viewed by 49 | Submission Open
Keywords: cancer treatment; CAR T-cell therapy; CAR NK-cell therapy
(This special issue belongs to the Section Cell Biology and Pathology)
Obesity and Cardiovascular Disease
edited by Timothy P. Fitzgibbons
submission deadline 30 Apr 2025 | Viewed by 49 | Submission Open
Keywords: GLP-1 agonists; immunometabolism; diabetes; perivascular fat; epicardial fat; heart failure; atherosclerosis; genetics
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in Combination Therapy for Chronic Diseases: Bridging Conventional and Natural Products for Enhanced Outcomes
edited by
submission deadline 30 Apr 2025 | Viewed by 49 | Submission Open
Keywords: combination therapy; interaction; chronic diseases; synergy; molecular pathways; mathematical methods; minimizing side effects
(This special issue belongs to the Section Molecular and Translational Medicine)
Alternative Methods of Treating Bacterial Infections
edited by Agata Pruss, Helena Masiuk and
submission deadline 30 Apr 2025 | Viewed by 45 | Submission Open
Keywords: alternative treatments; bacterial resistance; drug discovery; new methods of treatment of infections
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Past, Present and Further Looking for Therapeutic Management of Pancreatic Ductal Adenocarcinoma (2nd Edition) submission deadline 30 Apr 2025 | Viewed by 41 | Submission Open
Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; treatment pancreatic cancer; chemotherapy pancreatic cancer; radiotherapy pancreatic cancer; pancreatic cancer biology; PDAC preclinical model; biomolecular markers; theragnostic molecules; target therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Poly-Pharmacological Effects and Mechanisms of Phytochemicals
edited by
submission deadline 30 Apr 2025 | Viewed by 37 | Submission Open
Keywords: phytochemicals; natural products; poly-pharmacology; novel application; research updates on phytochemicals
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Hepatocellular Carcinoma: From Pathophysiology to Therapeutic Approaches Treatment
edited by
submission deadline 30 Apr 2025 | Viewed by 35 | Submission Open
Keywords: hepatocellular carcinoma; pathophysiology; therapeutic interventions
(This special issue belongs to the Section Cancer Biology and Oncology)
Advances in Brain Tumor Diagnosis: Innovations and Emerging Technologies submission deadline 30 Apr 2025 | Viewed by 34 | Submission Open
Keywords: brain tumor diagnosis; artificial intelligence in oncology; deep learning in medical imaging; machine learning models; predictive analytics in healthcare; digital pathology; glioma detection; multi-modal data integration; neuro-oncology; precision medicine
The Role of HOX Genes in Particular Cancers
edited by
submission deadline 30 Apr 2025 | Viewed by 33 | Submission Open
Keywords: HOX genes; anti-cancer drugs; cell memory program; Epigenetic regulation
(This special issue belongs to the Section Cancer Biology and Oncology)
Exploring Human Diseases through Genomic and Genetic Analyses
edited by Fernando Regateiro and
submission deadline 30 Apr 2025 | Viewed by 31 | Submission Open
Keywords: genomic and genetic analyses; genomic medicine; personalized medicine; technologies and testing methods; complex diseases; monogenic diseases; pharmacogenomics
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
The Role of Iron in Human Diseases
edited by Margherita Correnti
submission deadline 30 Apr 2025 | Viewed by 31 | Submission Open
Keywords: iron metabolism; iron dysregulation; diseases; iron deficiency; iron overload
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Organoids for Disease Studies and Drug Development
edited by Shijie He
submission deadline 30 Apr 2025 | Viewed by 31 | Submission Open
Keywords: organoid; disease model; disease development; drug development
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances of Magnesium and Zinc in Health and Diseases
edited by Mihai Nechifor
submission deadline 30 Apr 2025 | Viewed by 29 | Submission Open
Keywords: magnesium; zinc; metabolic disorders; neurodegenerative diseases; mood disorders; immune system; microbiota; cardiovascular diseases; reproduction; physical performance
(This special issue belongs to the Section Molecular and Translational Medicine)
Navigating the Tumor Microenvironment: The Role of Reactive Oxygen Species in Cancer Progression and Therapy
edited by
submission deadline 30 Apr 2025 | Viewed by 27 | Submission Open
Keywords: tumor microenvironment; reactive oxygen species; oxidative stress; antioxidants; tumor-infiltrated immune cells
(This special issue belongs to the Section Cancer Biology and Oncology)
Molecular Insights and Translational Approaches in Musculoskeletal Disorders
edited by Priyanka Kushwaha
submission deadline 30 Apr 2025 | Viewed by 24 | Submission Open
Keywords: musculoskeletal disorders; osteoarthritis; rheumatoid arthritis
(This special issue belongs to the Section Molecular and Translational Medicine)
Chemoprevention to Dwindle Tumor Development
edited by
submission deadline 30 Apr 2025 | Viewed by 24 | Submission Open
Keywords: tumor; carcinogenesis; dysplasia; neoplasm; chemoprevention
(This special issue belongs to the Section Cancer Biology and Oncology)
The Molecular Mechanisms of Hearing, Balance and Deafness submission deadline 30 Apr 2025 | Viewed by 16 | Submission Open
Keywords: hearing; balance; deafness; molecular mechanisms; genetics; transcriptomics
(This special issue belongs to the Section Molecular and Translational Medicine)
Molecular Mechanisms and Therapeutic Strategies of Metabolic Dysfunction-Associated Diseases submission deadline 20 May 2025 | Viewed by 39 | Submission Open
Keywords: metabolic dysfunction; metabolic syndrome; therapeutic strategies; obesity; diabetes; cardiovascular diseases; non-alcoholic fatty liver disease; genetic regulation; cellular metabolism; pharmacological interventions
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Extracellular Vesicles and Exosomes as Therapeutic Agents submission deadline 31 May 2025 | 7 articles | Viewed by 16373 | Submission Open
Keywords: extracellular vesicles; exosomes; therapeutics; drug delivery; bioengineering
(This special issue belongs to the Section Cell Biology and Pathology)
Thyroid Disease: From Mechanism to Therapeutic Approaches
edited by
submission deadline 31 May 2025 | 7 articles | Viewed by 13708 | Submission Open
Keywords: pathogenesis and molecular mechanism of thyroid diseases; genetic disorders of the thyroid biomarkers for thyroid dysfunctions; diagnostic challenges; new thyroid’ s therapies; immunotherapy; nuclear medicine; minimal invasive treatment
(This special issue belongs to the Section Molecular and Translational Medicine)
Urothelial Carcinoma: Role of Biomarkers in Diagnosis, Prognosis and Treatment
edited by Ioannis Zachos and
submission deadline 31 May 2025 | 8 articles | Viewed by 12992 | Submission Open
Keywords: urothelial carcinoma; biomarker; diagnosis; treatment; prognosis
(This special issue belongs to the Section Molecular and Translational Medicine)
Human Stem Cells in Disease Modelling and Treatment
edited by Sofia M. Calado and
submission deadline 31 May 2025 | 4 articles | Viewed by 5152 | Submission Open
Keywords: induced pluripotent stem cells (iPSCs); embryonic stem cells (ESCs); disease models; cell therapies; cell therapy medicinal products (CTMPs); regenerative medicine
(This special issue belongs to the Section Biomedical Engineering and Materials)
Leishmaniasis: Pathophysiology, Diagnostics and Current and Emerging Therapeutic Approaches
edited by Raimunda Nonata Ribeiro Sampaio
submission deadline 31 May 2025 | 3 articles | Viewed by 4961 | Submission Open
Keywords: leishmaniasis; pathophysiology
(This special issue belongs to the Section Molecular and Translational Medicine)
Histone Deacetylase and Its Inhibitors: Drug Discovery, Molecular Mechanism, and Clinical Implications
edited by
submission deadline 31 May 2025 | 2 articles | Viewed by 3023 | Submission Open
Keywords: HDACs inhibitors; molecular mechanism; molecular dynamics; virtual screening
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Cellular Senescence in Age-Related Diseases: Pathophysiology and Therapeutic Approaches submission deadline 31 May 2025 | 2 articles | Viewed by 2547 | Submission Open
Keywords: cellular senescence; senescence-associated secretory phenotype; aging; senolytics; senomorphics; senoreverters; therapeutics
(This special issue belongs to the Section Cell Biology and Pathology)
Advanced Research in Neuroprotection
edited by Evangelia Kesidou, Iliana Michailidou and
submission deadline 31 May 2025 | 2 articles | Viewed by 2264 | Submission Open
Keywords: neuroprotection; neurodegeneration; neuroinflammation; axonal loss; neuropharmacology; traumatic brain injury; blood– brain barrier
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Glaucoma: New Diagnostic and Therapeutic Approaches, 2nd Edition
edited by
submission deadline 31 May 2025 | 3 articles | Viewed by 2118 | Submission Open
Keywords: glaucoma; ocular pharmacology; ocular disease
(This special issue belongs to the Section Molecular and Translational Medicine)
Antibody–Drug Conjugates and Cancer Immunotherapy
edited by Sofia Genta
submission deadline 31 May 2025 | 1 articles | Viewed by 2053 | Submission Open
Keywords: ADC; immunotherapy; cancer; drug resistance; tumor microenvironment
(This special issue belongs to the Section Cancer Biology and Oncology)
Periodontal Disease: From Pathophysiology to Novel Therapeutic Approaches
edited by
submission deadline 31 May 2025 | 3 articles | Viewed by 1848 | Submission Open
Keywords: periodontal disease; oral microbiome; dysbiosis; artificial intelligence (AI); personalized therapeutic interventions
(This special issue belongs to the Section Molecular and Translational Medicine)
Genomic Insights and Translational Opportunities for Human Cancers submission deadline 31 May 2025 | 1 articles | Viewed by 1798 | Submission Open
Keywords: genomics; cancer genomics; biomarkers; machine learning; bioinformatics; liquid biopsies; cell-free DNA; cell-free RNA
(This special issue belongs to the Section Cancer Biology and Oncology)
Extracellular Vesicles for Diagnosis and Treatment of Human Diseases
edited by
submission deadline 31 May 2025 | 2 articles | Viewed by 1756 | Submission Open
Keywords: human diseases; extracellular vesicles; biomarkers; diagnosis; prognosis; therapeutic targets; therapeutic applications; EV engineering; physiology; pathology
(This special issue belongs to the Section Molecular and Translational Medicine)
New Advances in the Role of Regulatory T Cells in Immunity
edited by Mehdi Benamar
submission deadline 31 May 2025 | 1 articles | Viewed by 1690 | Submission Open
Keywords: regulatory T cells; immune regulation; autoimmune diseases; tolerance; Foxp3; immunomodulatory therapies
(This special issue belongs to the Section Immunology and Immunotherapy)
Neuroinflammation and Neuroprotection
edited by
submission deadline 31 May 2025 | 2 articles | Viewed by 1687 | Submission Open
Keywords: neuroinflammation; neurodegeneration; mechanisms; disease progression; ER stress; oxidative stress; mitochondrial dysfunction
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
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