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Biosensors
Special Issues
Application of Biosensors in Cell or Tissue Analysis
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Application of Biosensors in Cell or Tissue Analysis

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 5530

Special Issue Editors

Dr. Vasa Radonic

E-Mail Website
Guest Editor
Biosense Institute, University of Novi Sad, Novi Sad, Serbia
Interests: biosensors; microfluidics; lab-on-a-chip devices; micro and nano fabrication technologies; electrochemical sensor; electronic read-out
Dr. Ivana Gadjanski

E-Mail Website
Guest Editor
BioSense Institute, University of Novi Sad, Novi Sad 21000, Serbia
Interests: biosensors; microfluidics; cultured meat; cellular agriculture; pathogens
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues

Nowadays, tissue engineering, which deals with the growth and development of cells, scaffold materials, organs and engineered tissues in distinctive culturing conditions, has found applications in regenerative medicine, in vitro and in vivo testing, and alternative protein production via cellular agriculture, particularly concerning cultured meat fabrication.

Biosensors are a powerful tool that allow for the monitoring of different physicochemical processes during cell cultivation, including cellular activities, the consumption of nutrients, and the releasing of metabolites or hormones.

Authors are invited to submit manuscripts that are within the scope of this Special Issue, including, but not limited to, topics related to different biosensing principles; sensor fabrication and integration; novel applications of biomaterials and nanomaterials in biosensors; the development of enzyme, aptamer, antibody or nucleic acid-based biosensors; and sensor integration with microfluidic devices or the development of organ-on-chip systems for the measurement or monitoring of different parameters in cell/tissue culture processes and different tissue engineering approaches.

Dr. Vasa Radonic
Dr. Ivana Gadjanski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • monitoring of cell culture processes
  • tissue/organ-based biosensors
  • tissue analysis
  • metabolite biosensors
  • nutrient biosensors
  • nanomaterials biosensors
  • label-free biosensors
  • cell-based biosensors
  • microsystems and single-cell analysis
  • alternative protein and cultivated meat

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

13 pages, 5847 KiB  
Article
Highly Sensitive Detection of Hydrogen Peroxide in Cancer Tissue Based on 3D Reduced Graphene Oxide–MXene–Multi-Walled Carbon Nanotubes Electrode
by Shuai-Qun Yu, Pan Li, Hao-Jie Li, Ling-Jun Shang, Rui Guo, Xu-Ming Sun and Qiong-Qiong Ren
Biosensors 2024, 14(6), 261; https://doi.org/10.3390/bios14060261 - 21 May 2024
Cited by 1 | Viewed by 1541
Abstract
Hydrogen peroxide (H2O2) is a signaling molecule that has the capacity to control a variety of biological processes in organisms. Cancer cells release more H2O2 during abnormal tumor growth. There has been a considerable amount of [...] Read more.
Hydrogen peroxide (H2O2) is a signaling molecule that has the capacity to control a variety of biological processes in organisms. Cancer cells release more H2O2 during abnormal tumor growth. There has been a considerable amount of interest in utilizing H2O2 as a biomarker for the diagnosis of cancer tissue. In this study, an electrochemical sensor for H2O2 was constructed based on 3D reduced graphene oxide (rGO), MXene (Ti3C2), and multi-walled carbon nanotubes (MWCNTs) composite. Three-dimensional (3D) rGO–Ti3C2–MWCNTs sensor showed good linearity for H2O2 in the ranges of 1–60 μM and 60 μM–9.77 mM at a working potential of −0.25 V, with sensitivities of 235.2 µA mM−1 cm−2 and 103.8 µA mM−1 cm−2, respectively, and a detection limit of 0.3 µM (S/N = 3). The sensor exhibited long-term stability, good repeatability, and outstanding immunity to interference. In addition, the modified electrode was employed to detect real-time H2O2 release from cancer cells and cancer tissue ex vivo. Full article
(This article belongs to the Special Issue Application of Biosensors in Cell or Tissue Analysis)
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12 pages, 3982 KiB  
Article
Development of a Flexible Sensor-Integrated Tissue Patch to Monitor Early Organ Rejection Processes Using Impedance Spectroscopy
by Peter Ertl, Tibor Wladimir, Drago Sticker, Patrick Schuller, Mario Rothbauer, Georg Wieselthaler and Martin Frauenlob
Biosensors 2024, 14(5), 253; https://doi.org/10.3390/bios14050253 - 17 May 2024
Viewed by 1709
Abstract
Heart failure represents a primary cause of hospitalization and mortality in both developed and developing countries, often necessitating heart transplantation as the only viable recovery path. Despite advances in transplantation medicine, organ rejection remains a significant post-operative challenge, traditionally monitored through invasive endomyocardial [...] Read more.
Heart failure represents a primary cause of hospitalization and mortality in both developed and developing countries, often necessitating heart transplantation as the only viable recovery path. Despite advances in transplantation medicine, organ rejection remains a significant post-operative challenge, traditionally monitored through invasive endomyocardial biopsies (EMB). This study introduces a rapid prototyping approach to organ rejection monitoring via a sensor-integrated flexible patch, employing electrical impedance spectroscopy (EIS) for the non-invasive, continuous assessment of resistive and capacitive changes indicative of tissue rejection processes. Utilizing titanium-dioxide-coated electrodes for contactless impedance sensing, this method aims to mitigate the limitations associated with EMB, including procedural risks and the psychological burden on patients. The biosensor’s design features, including electrode passivation and three-dimensional microelectrode protrusions, facilitate effective monitoring of cardiac rejection by aligning with the heart’s curvature and responding to muscle contractions. Evaluation of sensor performance utilized SPICE simulations, scanning electron microscopy, and cyclic voltammetry, alongside experimental validation using chicken heart tissue to simulate healthy and rejected states. The study highlights the potential of EIS in reducing the need for invasive biopsy procedures and offering a promising avenue for early detection and monitoring of organ rejection, with implications for patient care and healthcare resource utilization. Full article
(This article belongs to the Special Issue Application of Biosensors in Cell or Tissue Analysis)
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Graphical abstract

14 pages, 3422 KiB  
Communication
Towards the Application of a Label-Free Approach for Anti-CD47/PD-L1 Bispecific Antibody Discovery
by Artem S. Grevtsev, Alexandra D. Azarian, Alexey K. Misorin, Daria O. Chernyshova, Pavel A. Iakovlev and Mikhail S. Karbyshev
Biosensors 2023, 13(12), 1022; https://doi.org/10.3390/bios13121022 - 9 Dec 2023
Cited by 1 | Viewed by 1921
Abstract
The engineering of bispecific antibodies that exhibit optimal affinity and functional activity presents a significant scientific challenge. To tackle this, investigators employ an assortment of protein assay techniques, such as label-free interaction methodologies, which offer rapidity and convenience for the evaluation of extensive [...] Read more.
The engineering of bispecific antibodies that exhibit optimal affinity and functional activity presents a significant scientific challenge. To tackle this, investigators employ an assortment of protein assay techniques, such as label-free interaction methodologies, which offer rapidity and convenience for the evaluation of extensive sample sets. These assays yield intricate data pertaining to the affinity towards target antigens and Fc-receptors, instrumental in predicting cellular test outcomes. Nevertheless, the fine-tuning of affinity is of paramount importance to mitigate potential adverse effects while maintaining efficient obstruction of ligand–receptor interactions. In this research, biolayer interferometry (BLI) was utilized to probe the functional characteristics of bispecific antibodies targeting cluster of differentiation 47 (CD47) and programmed death-ligand 1 (PD-L1) antigens, encompassing affinity, concurrent binding to two disparate antigens, and the inhibition of ligand–receptor interactions. The findings derived from BLI were juxtaposed with data from in vitro signal regulatory protein-α (SIRP-α)/CD47 blockade reporter bioassays for two leading bispecific antibody candidates, each demonstrating distinct affinity to CD47. Full article
(This article belongs to the Special Issue Application of Biosensors in Cell or Tissue Analysis)
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