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Biosensors
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Recent Advances in Hydrogels-Based Biosensors for Point-of-Care Testing
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Recent Advances in Hydrogels-Based Biosensors for Point-of-Care Testing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 7685

Special Issue Editors

Dr. Tao Hu

E-Mail Website
Guest Editor
Jiangsu Key Laboratory for Design and Manufacture of Micro–Nano Biomedical Instruments, School of Mechanical Engineering, Southeast University, Nanjing, China
Interests: biosensors
Dr. Zhaozhu Zheng

E-Mail Website
Guest Editor
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China
Interests: silk-fibroin-based biological (medical) materials; biological 3D printing; wearable devices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hydrogel formed by cross-linking covalent or non-covalent bonds is a kind of flexible polymer material with a three-dimensional spatial network structure. At present, hydrogels, which are hydrophilic and moisturizing, soft and flexible, non-toxic, and biocompatible, have been widely used in the biomedical (antibacterial hemostasis, controlled drug release, tissue regeneration, etc.) and flexible electronics (sensing, energy storage, actuation, etc.) fields. Herein, smart hydrogels possess the ability to respond to various external stimuli (temperature, light, electric field, pH, etc.), which can be applied to disease detection, environmental monitoring, field monitoring, etc. Moreover, the functional enhancement of hydrogels should be obtained with methods such as conductive functionalization, mechanical enhancement, and self-repair function. Hence, the integration of engineering technology and biological systems can be realized on the basis of the biocompatibility and mechanical flexibility of hydrogels, promoting the development of the field of flexible bioelectronics.

Dr. Tao Hu
Dr. Zhaozhu Zheng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors (temperature, pH/specific antigen/uric acid, strain/stress, humidity)
  • self-powered biosensors
  • wearable biosensors
  • flexible biosensors
  • implantable biosensors
  • biosensors for drug delivery
  • biological scaffolds

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Published Papers (4 papers)

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Research

14 pages, 3205 KiB  
Article
High-Performance Flexible PLA/BTO-Based Pressure Sensor for Motion Monitoring and Human–Computer Interaction
by Xuguang Sui, Qingmiao Mu, Jia Li, Bo Zhao, Hongxi Gu, Han Yu, Juan Du, Lijun Ren and Dengwei Hu
Biosensors 2024, 14(10), 508; https://doi.org/10.3390/bios14100508 - 17 Oct 2024
Viewed by 967
Abstract
Flexible electronics show wide application prospects in electronic skin, health monitoring, and human–machine interfacing. As an essential part of flexible electronics, flexible pressure sensors have become a compelling subject of academic research. There is an urgent need to develop piezoelectric sensors with high [...] Read more.
Flexible electronics show wide application prospects in electronic skin, health monitoring, and human–machine interfacing. As an essential part of flexible electronics, flexible pressure sensors have become a compelling subject of academic research. There is an urgent need to develop piezoelectric sensors with high sensitivity and stability. In this work, the high flexibility of polylactic acid (PLA) film and the excellent ferroelectric properties and high dielectric constant of tetragonal barium titanate (BTO) led to their use as filling materials to fabricate flexible piezoelectric composite films by spinning coating. PLA is used to produce flexible binding substrates, and BTO is added to the composite to enhance its electrical output by improving its piezoelectric performance. The peak output voltage of the PLA/BTO tetragonal piezoelectric film is 22.57 V, and the maximum short-circuit current was 3041 nA. Durability tests showed that during 40,000 s of continuous operation, in the range of 15~120 kPa, the linear relationship between pressure and the film was excellent, the sensitivity for the output voltage is 0.176 V/kPa, and the output current is 27.77 nA/kPa. The piezoelectric pressure sensor (PPS) also enables accurate motion detection, and the extensive capabilities of the PENG highlight its potential in advancing motion sensing and human–computer interactions. Full article
(This article belongs to the Special Issue Recent Advances in Hydrogels-Based Biosensors for Point-of-Care Testing)
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12 pages, 2818 KiB  
Article
A Nanoparticle-Coated Cellulose Acetate Membrane for Highly Efficient, Low-Cost Circulating Tumor Cell Detection
by Yize Zhao, Yaqi Pan, Hao Sun, Pengfei Huo, Guangtong Wang and Shaoqin Liu
Biosensors 2024, 14(10), 472; https://doi.org/10.3390/bios14100472 - 1 Oct 2024
Viewed by 933
Abstract
Detecting circulating tumor cells has exhibited great significance in treating cancers since its concentration is an index strongly associated with the development and transfer of the tumor. However, the present commercial method for CTC detection is still expensive, because special antibodies and complicated [...] Read more.
Detecting circulating tumor cells has exhibited great significance in treating cancers since its concentration is an index strongly associated with the development and transfer of the tumor. However, the present commercial method for CTC detection is still expensive, because special antibodies and complicated devices must be used for cell separation and imaging. Hence, it is quite necessary to apply alternative materials and methods to decrease the cost of CTC detection. In this article, we coated a cellulose acetate membrane with nanoparticles formed by the polymerization of melamine and furfural, creating a surface with nanoscale roughness for the highly efficient capture of the sparse CTCs in a blood sample. Subsequently, the CTCs on the surface can be quantitatively detected by colorimetry with the aid of a COF-based nanozyme. The detection limit (LOD) can be as low as 3 cells/mL, which is the lowest LOD among the colorimetric methods to our knowledge. Considering the low cost of fabricating the membrane for CTC capture and the robustness of nanozymes compared with natural enzymes, this CTC detection approach displays great potential to decrease the financial burden of commercial CTC detection. Full article
(This article belongs to the Special Issue Recent Advances in Hydrogels-Based Biosensors for Point-of-Care Testing)
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14 pages, 9835 KiB  
Article
Controllable Fabrication of Sub-10 nm Graphene Nanopores via Helium Ion Microscopy and DNA Detection
by Zhishan Yuan, Yanbang Lin, Jieming Hu and Chengyong Wang
Biosensors 2024, 14(4), 158; https://doi.org/10.3390/bios14040158 - 27 Mar 2024
Cited by 1 | Viewed by 3081
Abstract
Solid-state nanopores have become a prominent tool in the field of single-molecule detection. Conventional solid-state nanopores are thick, which affects the spatial resolution of the detection results. Graphene is the thinnest 2D material and has the highest spatial detection resolution. In this study, [...] Read more.
Solid-state nanopores have become a prominent tool in the field of single-molecule detection. Conventional solid-state nanopores are thick, which affects the spatial resolution of the detection results. Graphene is the thinnest 2D material and has the highest spatial detection resolution. In this study, a graphene membrane chip was fabricated by combining a MEMS process with a 2D material wet transfer process. Raman spectroscopy was used to assess the quality of graphene after the transfer. The mechanism behind the influence of the processing dose and residence time of the helium ion beam on the processed pore size was investigated. Subsequently, graphene nanopores with diameters less than 10 nm were fabricated via helium ion microscopy. DNA was detected using a 5.8 nm graphene nanopore chip, and the appearance of double-peak signals on the surface of 20 mer DNA was successfully detected. These results serve as a valuable reference for nanopore fabrication using 2D material for DNA analysis. Full article
(This article belongs to the Special Issue Recent Advances in Hydrogels-Based Biosensors for Point-of-Care Testing)
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12 pages, 1913 KiB  
Article
ZIF-67 Anchored on MoS2/rGO Heterostructure for Non-Enzymatic and Visible-Light-Sensitive Photoelectrochemical Biosensing
by Qiaolin Fan, Xiao Li, Hui Dong, Zhonghua Ni and Tao Hu
Biosensors 2024, 14(1), 38; https://doi.org/10.3390/bios14010038 - 12 Jan 2024
Cited by 3 | Viewed by 2122
Abstract
Graphene and graphene-like two-dimensional layered nanomaterials-based photoelectrochemical (PEC) biosensors have recently grown rapidly in popularity thanks to their advantages of high sensitivity and low background signal, which have attracted tremendous attention in ultrahigh sensitive small molecule detection. This work proposes a non-enzymatic and [...] Read more.
Graphene and graphene-like two-dimensional layered nanomaterials-based photoelectrochemical (PEC) biosensors have recently grown rapidly in popularity thanks to their advantages of high sensitivity and low background signal, which have attracted tremendous attention in ultrahigh sensitive small molecule detection. This work proposes a non-enzymatic and visible-light-sensitive PEC biosensing platform based on ZIF-67@MoS2/rGO composite which is synthesized through a facile and one-step microwave-assisted hydrothermal method. The combination of MoS2 and rGO could construct van der Waals heterostructures, which not only act as visible-light-active nanomaterials, but facilitate charge carriers transfer between the photoelectrode and glassy carbon electrode (GCE). ZIF-67 anchored on MoS2/rGO heterostructures provides large specific surface areas and a high proportion of catalytic sites, which cooperate with MoS2 nanosheets, realizing rapid and efficient enzyme-free electrocatalytic oxidation of glucose. The ZIF-67@MoS2/rGO-modified GCE can realize the rapid and sensitive detection of glucose at low detection voltage, which exhibits a high sensitivity of 12.62 μAmM−1cm−2. Finally, the ZIF-67@MoS2/rGO PEC biosensor is developed by integrating the ZIF-67@MoS2/rGO with a screen-printed electrode (SPE), which exhibits a high sensitivity of 3.479 μAmM−1cm−2 and a low detection limit of 1.39 μM. The biosensor’s selectivity, stability, and repeatability are systematically investigated, and its practicability is evaluated by detecting clinical serum samples. Full article
(This article belongs to the Special Issue Recent Advances in Hydrogels-Based Biosensors for Point-of-Care Testing)
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