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Biosensors
Special Issues
Advanced SERS Biosensors for Detection and Analysis
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Advanced SERS Biosensors for Detection and Analysis

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 3608

Special Issue Editors

Dr. Peini Zhao

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
Interests: biosensors; SERS paper chip sensor; 3D nanomaterials; application in environmental analysis
Prof. Dr. Lulu Qu

E-Mail Website
Guest Editor
School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, China
Interests: SERS-based sensing materials and detection methods; spectral analysis techniques for biological molecules in living cells
Dr. Min Su

E-Mail Website
Guest Editor
School of Pharmacy and Pharmaceutical Science, Xiamen Medical College, Xiamen 361023, China
Interests: biosensors; surface-enhanced Raman spectroscopy; in situ/operando Raman spectroscopy characterization; rapid Raman detection in the fields of public security and life or health

Special Issue Information

Dear Colleagues,

In recent years, the fields of health diagnosis, food and environmental monitoring, and emergency security have been the focus of extensive scientific research. With environmental pollution, the pressure of work and the pace of life, and unhealthy living habits, the incidence of cardiovascular diseases, cancer, chronic respiratory diseases, diabetes, and mental depression is proliferating year by year. As a crucial component of the human body, biomolecules are widely involved in various physiological activities of the human body and are related to a variety of diseases. Because the trace detection and analysis of biomolecules is closely related to the timely diagnosis of major diseases, food safety and environmental problems, it can be used as a reference for judgment. Therefore, the research of rapid, simple, economical, portable, and location-free sensing platforms is of great practical significance. Surface-enhanced Raman spectroscopy (SERS) detection technology has been widely employed in biological imaging, analytical chemistry, disease diagnosis, food safety and other fields due to its ultra-high sensitivity, rapid spectral acquisition speed, real-time and on-site detection. Accordingly, this Special Issue is dedicated to collecting articles addressing significant advances in innovative research on advanced SERS biosensors for detection and analysis.

Dr. Peini Zhao
Prof. Dr. Lulu Qu
Dr. Min Su
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • SERS
  • biosensor
  • rapid Raman detection
  • SERS-based sensing materials
  • point-of-care testing
  • biochemical analysis

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Published Papers (3 papers)

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Research

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14 pages, 2952 KiB  
Article
Highly Sensitive and Wide-Range Detection of Thiabendazole via Surface-Enhanced Raman Scattering Using Bimetallic Nanoparticle-Functionalized Nanopillars
by Hyunjun Park, Gayoung Kim, Woochang Kim, Eugene Park, Joohyung Park and Jinsung Park
Biosensors 2024, 14(3), 133; https://doi.org/10.3390/bios14030133 - 4 Mar 2024
Viewed by 1965
Abstract
Thiabendazole (TBZ) is a benzimidazole; owing to its potent antimicrobial properties, TBZ is extensively employed in agriculture as a fungicide and pesticide. However, TBZ poses environmental risks, and excessive exposure to TBZ through various leakage pathways can cause adverse effects in humans. Therefore, [...] Read more.
Thiabendazole (TBZ) is a benzimidazole; owing to its potent antimicrobial properties, TBZ is extensively employed in agriculture as a fungicide and pesticide. However, TBZ poses environmental risks, and excessive exposure to TBZ through various leakage pathways can cause adverse effects in humans. Therefore, a method must be developed for early and sensitive detection of TBZ over a range of concentrations, considering both human and environmental perspectives. In this study, we used silver nanopillar structures (SNPis) and Au@Ag bimetallic nanoparticles (BNPs) to fabricate a BNP@SNPi substrate. This substrate exhibited a broad reaction surface with significantly enhanced surface-enhanced Raman scattering hotspots, demonstrating excellent Raman performance, along with high reproducibility, sensitivity, and selectivity for TBZ detection. Ultimately, the BNP@SNPi substrate successfully detected TBZ across a wide concentration range in samples of tap water, drinking water, juice, and human serum, with respective limits of detection of 146.5, 245.5, 195.6, and 219.4 pM. This study highlights BNP@SNPi as a promising sensor platform for TBZ detection in diverse environments and contributes to environmental monitoring and bioanalytical studies. Full article
(This article belongs to the Special Issue Advanced SERS Biosensors for Detection and Analysis)
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Review

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25 pages, 1274 KiB  
Review
SERS Sensors with Bio-Derived Substrates Under the Way to Agricultural Monitoring of Pesticide Residues
by Kseniya V. Serebrennikova, Nadezhda S. Komova, Anatoly V. Zherdev and Boris B. Dzantiev
Biosensors 2024, 14(12), 573; https://doi.org/10.3390/bios14120573 (registering DOI) - 26 Nov 2024
Abstract
Uncontrolled use of pesticides in agriculture leads to negative consequences for the environment, as well as for human and animal health. Therefore, timely detection of pesticides will allow application of measures to eliminate the excess of maximum residue limits and reduce possible negative [...] Read more.
Uncontrolled use of pesticides in agriculture leads to negative consequences for the environment, as well as for human and animal health. Therefore, timely detection of pesticides will allow application of measures to eliminate the excess of maximum residue limits and reduce possible negative consequences in advance. Common methods of pesticide analysis suffer from high costs, and are time consuming, and labor intensive. Currently, more attention is being paid to the development of surface-enhanced Raman scattering (SERS) sensors as a non-destructive and highly sensitive tool for detecting various chemicals in agricultural applications. This review focuses on the current developments of biocompatible SERS substrates based on natural materials with unique micro/nanostructures, flexible SERS substrates based on biopolymers, as well as functionalized SERS substrates, which are close to the current needs and requirements of agricultural product quality control and environmental safety assessment. The impact of herbicides on the process of photosynthesis is considered and the prospects for the application of Raman spectroscopy and SERS for the detection of herbicides are discussed. Full article
(This article belongs to the Special Issue Advanced SERS Biosensors for Detection and Analysis)
42 pages, 14006 KiB  
Review
Black Silicon Surface-Enhanced Raman Spectroscopy Biosensors: Current Advances and Prospects
by Yaraslau Padrez and Lena Golubewa
Biosensors 2024, 14(10), 453; https://doi.org/10.3390/bios14100453 - 24 Sep 2024
Viewed by 996
Abstract
Black silicon was discovered by accident and considered an undesirable by-product of the silicon industry. A highly modified surface, consisting of pyramids, needles, holes, pillars, etc., provides high light absorption from the UV to the NIR range and gives black silicon its color—matte [...] Read more.
Black silicon was discovered by accident and considered an undesirable by-product of the silicon industry. A highly modified surface, consisting of pyramids, needles, holes, pillars, etc., provides high light absorption from the UV to the NIR range and gives black silicon its color—matte black. Although black silicon has already attracted some interest as a promising material for sensitive sensors, the potential of this material has not yet been fully exploited. Over the past three decades, black silicon has been actively introduced as a substrate for surface-enhanced Raman spectroscopy (SERS)—a molecule-specific vibrational spectroscopy technique—and successful proof-of-concept experiments have been conducted. This review focuses on the current progress in black silicon SERS biosensor fabrication, the recent advances in the design of the surface morphology and an analysis of the relation of surface micro-structuring and SERS efficiency and sensitivity. Much attention is paid to problems of non-invasiveness of the technique and biocompatibility of black silicon, its advantages over other SERS biosensors, cost-effectiveness and reproducibility, as well as the expansion of black silicon applications. The question of existing limitations and ways to overcome them is also addressed. Full article
(This article belongs to the Special Issue Advanced SERS Biosensors for Detection and Analysis)
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