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Biosensors
Special Issues
Advanced Nanomaterials for Electrochemical Biosensing Application
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Advanced Nanomaterials for Electrochemical Biosensing Application

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 9235

Special Issue Editor

Prof. Dr. Sungbo Cho

E-Mail Website
Guest Editor
Department of Electronic Engineering, Gachon University, Seongnam 13120, Gyeonggi-Do, Republic of Korea
Interests: electrochemical biosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sustainable and multifunctional nanostructured advanced materials have been significantly growing in importance due to their unique physio-chemical properties. Thus, attention has been drawn towards their use in fabricating electrochemical sensors, which have persistently evolved in the fields of food management, environmental monitoring, disease diagnosis, and miniaturized devices. Utilizing state-of-the-art technology for synthesizing a multifunctional nanostructured material has opened up a new pathway which can allow the simultaneous detection of various biomolecules’ signals. Electrochemical detection methods have shown great benefits such as high sensitivity, high selectivity, rapid response, and affordability compared to other counterparts. Sustainable and multifunctional nanostructured materials coupled with electrochemical, liquid-gated, back-gated, dual-gated, and impedimetric methods have been showing promise as a technique for the detection of biomolecule signals. In this Special Issue we welcome original research articles, short communications, and review articles from researchers which focus on the following topics that are significantly related to sustainable nanostructured materials for biomolecule detection.

  • A new strategy for sustainable nanostructured materials synthesis for electrochemical and impedimetric detection.
  • A new strategy for the design and development of electrode fabrication techniques based on new advanced materials for biomolecule detection.

Design and development of paper-based electrochemical coupled-gated devices for biomolecule detection.

Prof. Dr. Sungbo Cho
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced nanostructured materials
  • foods
  • drug delivery
  • environment
  • disease
  • biosensing
  • DNA nanotechnology
  • real-time monitoring
  • smart electrochemical devices
  • miniaturized devices
  • paper-based electrochemical sensors

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Published Papers (4 papers)

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Research

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13 pages, 1579 KiB  
Article
Colorimetric and Electrochemical Dual-Mode Detection of Thioredoxin 1 Based on the Efficient Peroxidase-Mimicking and Electrocatalytic Property of Prussian Blue Nanoparticles
by Jeong Un Kim, Jee Min Kim, Annadurai Thamilselvan, Ki-Hwan Nam and Moon Il Kim
Biosensors 2024, 14(4), 185; https://doi.org/10.3390/bios14040185 - 10 Apr 2024
Cited by 3 | Viewed by 1721
Abstract
As a potent detection method for cancer biomarkers in physiological fluid, a colorimetric and electrochemical dual-mode sensing platform for breast cancer biomarker thioredoxin 1 (TRX1) was developed based on the excellent peroxidase-mimicking and electrocatalytic property of Prussian blue nanoparticles (PBNPs). PBNPs were hydrothermally [...] Read more.
As a potent detection method for cancer biomarkers in physiological fluid, a colorimetric and electrochemical dual-mode sensing platform for breast cancer biomarker thioredoxin 1 (TRX1) was developed based on the excellent peroxidase-mimicking and electrocatalytic property of Prussian blue nanoparticles (PBNPs). PBNPs were hydrothermally synthesized using K3[Fe(CN)6] as a precursor and polyvinylpyrrolidone (PVP) as a capping agent. The synthesized spherical PBNPs showed a significant peroxidase-like activity, having approximately 20 and 60% lower Km values for 3,3′,5,5′-tetramethylbenzidine (TMB) and H2O2, respectively, compared to those of horseradish peroxidase (HRP). The PBNPs also enhanced the electron transfer on the electrode surface. Based on the beneficial features, PBNPs were used to detect target TRX1 via sandwich-type immunoassay procedures. Using the strategies, TRX1 was selectively and sensitively detected, yielding limit of detection (LOD) values as low as 9.0 and 6.5 ng mL−1 via colorimetric and electrochemical approaches, respectively, with a linear range of 10–50 ng mL−1 in both strategies. The PBNP-based TRX1 immunoassays also exhibited a high degree of precision when applied to real human serum samples, demonstrating significant potentials to replace conventional HRP-based immunoassay systems into rapid, robust, reliable, and convenient dual-mode assay systems which can be widely utilized for the identification of important target molecules including cancer biomarkers. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Electrochemical Biosensing Application)
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Review

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33 pages, 4792 KiB  
Review
Bimetallic Coordination Polymers: Synthesis and Applications in Biosensing and Biomedicine
by Yanping Sun, Jianxin Ma, Faisal Ahmad, Yelan Xiao, Jingyang Guan, Tong Shu and Xueji Zhang
Biosensors 2024, 14(3), 117; https://doi.org/10.3390/bios14030117 - 22 Feb 2024
Cited by 3 | Viewed by 2781
Abstract
Bimetallic coordination polymers (CPs) have two different metal ions as connecting nodes in their polymer structure. The synthesis methods of bimetallic CPs are mainly categorized into the one-pot method and post-synthesis modifications according to various needs. Compared with monometallic CPs, bimetallic CPs have [...] Read more.
Bimetallic coordination polymers (CPs) have two different metal ions as connecting nodes in their polymer structure. The synthesis methods of bimetallic CPs are mainly categorized into the one-pot method and post-synthesis modifications according to various needs. Compared with monometallic CPs, bimetallic CPs have synergistic effects and excellent properties, such as higher gas adsorption rate, more efficient catalytic properties, stronger luminescent properties, and more stable loading platforms, which have been widely applied in the fields of gas adsorption, catalysis, energy storage as well as conversion, and biosensing. In recent years, the study of bimetallic CPs synergized with cancer drugs and functional nanomaterials for the therapy of cancer has increasingly attracted the attention of scientists. This review presents the research progress of bimetallic CPs in biosensing and biomedicine in the last five years and provides a perspective for their future development. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Electrochemical Biosensing Application)
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23 pages, 8588 KiB  
Review
A Review of Electroactive Nanomaterials in the Detection of Nitrogen-Containing Organic Compounds and Future Applications
by Mohanraj Jagannathan, Durgalakshmi Dhinasekaran, Ajay Rakkesh Rajendran and Sungbo Cho
Biosensors 2023, 13(11), 989; https://doi.org/10.3390/bios13110989 - 18 Nov 2023
Cited by 3 | Viewed by 2083
Abstract
Electrochemical and impedimetric detection of nitrogen-containing organic compounds (NOCs) in blood, urine, sweat, and saliva is widely used in clinical diagnosis. NOC detection is used to identify illnesses such as chronic kidney disease (CKD), end-stage renal disease (ESRD), cardiovascular complications, diabetes, cancer, and [...] Read more.
Electrochemical and impedimetric detection of nitrogen-containing organic compounds (NOCs) in blood, urine, sweat, and saliva is widely used in clinical diagnosis. NOC detection is used to identify illnesses such as chronic kidney disease (CKD), end-stage renal disease (ESRD), cardiovascular complications, diabetes, cancer, and others. In recent years, nanomaterials have shown significant potential in the detection of NOCs using electrochemical and impedimetric sensors. This potential is due to the higher surface area, porous nature, and functional groups of nanomaterials, which can aid in improving the sensing performance with inexpensive, direct, and quick-time processing methods. In this review, we discuss nanomaterials, such as metal oxides, graphene nanostructures, and their nanocomposites, for the detection of NOCs. Notably, researchers have considered nanocomposite-based devices, such as a field effect transistor (FET) and printed electrodes, for the detection of NOCs. In this review, we emphasize the significant importance of electrochemical and impedimetric methods in the detection of NOCs, which typically show higher sensitivity and selectivity. So, these methods will open a new way to make embeddable electrodes for point-of-detection (POD) devices. These devices could be used in the next generation of non-invasive analysis for biomedical and clinical applications. This review also summarizes recent state-of-the-art technology for the development of sensors for on-site monitoring and disease diagnosis at an earlier stage. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Electrochemical Biosensing Application)
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17 pages, 4257 KiB  
Review
A Brief Review of In Situ and Operando Electrochemical Analysis of Bacteria by Scanning Probes
by Tzu-En Lin and Sorour Darvishi
Biosensors 2023, 13(7), 695; https://doi.org/10.3390/bios13070695 - 30 Jun 2023
Cited by 1 | Viewed by 2022
Abstract
Bacteria are similar to social organisms that engage in critical interactions with one another, forming spatially structured communities. Despite extensive research on the composition, structure, and communication of bacteria, the mechanisms behind their interactions and biofilm formation are not yet fully understood. To [...] Read more.
Bacteria are similar to social organisms that engage in critical interactions with one another, forming spatially structured communities. Despite extensive research on the composition, structure, and communication of bacteria, the mechanisms behind their interactions and biofilm formation are not yet fully understood. To address this issue, scanning probe techniques such as atomic force microscopy (AFM), scanning electrochemical microscopy (SECM), scanning electrochemical cell microscopy (SECCM), and scanning ion-conductance microscopy (SICM) have been utilized to analyze bacteria. This review article focuses on summarizing the use of electrochemical scanning probes for investigating bacteria, including analysis of electroactive metabolites, enzymes, oxygen consumption, ion concentrations, pH values, biofilms, and quorum sensing molecules to provide a better understanding of bacterial interactions and communication. SECM has been combined with other techniques, such as AFM, inverted optical microscopy, SICM, and fluorescence microscopy. This allows a comprehensive study of the surfaces of bacteria while also providing more information on their metabolic activity. In general, the use of scanning probes for the detection of bacteria has shown great promise and has the potential to provide a powerful tool for the study of bacterial physiology and the detection of bacterial infections. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Electrochemical Biosensing Application)
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