Recent Advances in Nanomaterial-Based Biosensing and Diagnosis

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 2447

Special Issue Editors

School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
Interests: biosensing based on functional nanomaterials; microfluidic paper-based devices; fabricating and controlling solid–liquid interface; non-invasive diagnosis
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Guest Editor
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
Interests: ordered nanostructured arrays for nanodevices such as biosensors and gas sensors; interfacial analysis of inorganic–organic interfaces at the micro/nanoscale

Special Issue Information

Dear Colleagues,

Nanomaterials, including carbon nanomaterials, metal nanomaterials, silica nanoparticles, quantum dots, polymeric-based materials, and other functionalized nanoparticles, have attracted the extensive attention of scientists in view of their unique chemical, physical and size properties. They have provided great contributions to the development of biosensors and diagnosis over the past few decades. The ability to tailor the structure and therefore the properties of nanomaterials enables for desirable surface properties, crystallographic orientations, and biological activities, and this allows for the fabrication of novel application platforms for biosensing and diagnosis by improving performance. So far, various nanomaterial-based techniques on account of electrochemistry, chemiluminescence, electrochemiluminescence, fluorescence, surface plasmon resonance, and colorimetric analysis have been developed. Nevertheless, fully satisfying the continued growing demand for application platforms that have the advantages of high sensitivity, low cost, and convenient operation is still a challenge, especially for industry requirements with high-performance fabrication technology. It is believed that multidisciplinary collaborations will remain the focus for the future development of biosensing and diagnosis applications, which will further stimulate research interest from academia and industry. Accordingly, this Special Issue is devoted to a collection of significant advances on innovative research in the fabrication of different types of nanomaterial-based biosensors and diagnosis applications.

Dr. Kang Cui
Dr. Yizhong Huang
Guest Editors

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Keywords

  • nanomaterials
  • biosensors
  • biosensing
  • health biomarker
  • point-of-care testing
  • bioimaging
  • diagnosis

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Published Papers (2 papers)

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Research

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13 pages, 1638 KiB  
Article
Gold Nanoprobes for Detection of a Crucial EGFR Deletion for Early Diagnosis of Non-Small-Cell Lung Cancer
by Maria Enea, Anupong Nuekaew, Ricardo Franco and Eulália Pereira
Biosensors 2024, 14(4), 162; https://doi.org/10.3390/bios14040162 - 29 Mar 2024
Viewed by 2067
Abstract
Gold nanoparticles (AuNPs) exhibit improved optical and spectral properties compared to bulk materials, making them suitable for the detection of DNA, RNA, antigens, and antibodies. Here, we describe a simple, selective, and rapid non-cross linking detection assay, using approx. 35 nm spherical Au [...] Read more.
Gold nanoparticles (AuNPs) exhibit improved optical and spectral properties compared to bulk materials, making them suitable for the detection of DNA, RNA, antigens, and antibodies. Here, we describe a simple, selective, and rapid non-cross linking detection assay, using approx. 35 nm spherical Au nanoprobes, for a common mutation occurring in exon 19 of the epidermal growth factor receptor (EGFR), associated with non-small-cell lung cancer cells. AuNPs were synthesized based on the seed-mediated growth method and functionalized with a specific 16 bp thiolated oligonucleotide using a pH-assisted method. Both AuNPs and Au nanoprobes proved to be highly stable and monodisperse through ultraviolet-visible spectrophotometry, dynamic light scattering (DLS), and electrophoretic light scattering (ELS). Our results indicate a detection limit of 1.5 µg mL−1 using a 0.15 nmol dm−3 Au nanoprobe concentration. In conclusion, this work presents an effective possibility for a straightforward, fast, and inexpensive alternative for the detection of DNA sequences related to lung cancer, leading to a potential platform for early diagnosis of lung cancer patients. Full article
(This article belongs to the Special Issue Recent Advances in Nanomaterial-Based Biosensing and Diagnosis)
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Review

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18 pages, 4901 KiB  
Review
A Review of Current Developments in Functionalized Mesoporous Silica Nanoparticles: From Synthesis to Biosensing Applications
by Jiaojiao Zhou, Chen Liu, Yujun Zhong, Zhihui Luo and Long Wu
Biosensors 2024, 14(12), 575; https://doi.org/10.3390/bios14120575 - 27 Nov 2024
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Abstract
Functionalized mesoporous silica nanoparticles (MSNs) have been widely investigated in the fields of nanotechnology and material science, owing to their high surface area, diverse structure, controllable cavity, high biocompatibility, and ease of surface modification. In the past few years, great efforts have been [...] Read more.
Functionalized mesoporous silica nanoparticles (MSNs) have been widely investigated in the fields of nanotechnology and material science, owing to their high surface area, diverse structure, controllable cavity, high biocompatibility, and ease of surface modification. In the past few years, great efforts have been devoted to preparing functionalized MSNs for biosensing applications with satisfactory performance. The functional structure and composition in the synthesis of MSNs play important roles in high biosensing performance. With the development of material science, diverse functional units have been rationally incorporated into mesoporous structures, which endow MSNs with design flexibility and multifunctionality. Here, an overview of the recent developments of MSNs as nanocarriers is provided, including the methodologies for the preparation of MSNs and the nanostructures and physicochemical properties of MSNs, as well as the latest trends of MSNs and their use in biosensing. Finally, the prospects and challenges of MSNs are presented. Full article
(This article belongs to the Special Issue Recent Advances in Nanomaterial-Based Biosensing and Diagnosis)
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