Synaptic Plasticity in Brain and Nerves: New Vistas in Health and Diseases (2nd Edition)

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2110

Special Issue Editor


E-Mail Website
Guest Editor
UMR-S 1075 INSERM/Unicaen (COMETE), Campus Jules Horowitz, Boulevard Henri Becquerel, CEDEX 5, 14032 Caen, France
Interests: electrophysiology; long-term potentiation; glutamate; brain diseases; aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The efficiency of brain-dependent functions is closely related to optimal communication within neuronal networks, which is finely regulated by a myriad of adaptative processes involving interactions between the nerve and glial cell elements of the synaptic cleft. The capacity of brain plasticity that manages the network adaptation to environmental changes ranges from short-term modifications of cell morphology and functionality to long-term homeostatic responses. This new edition of Special Issue aims to showcase original articles and reviews that will improve our current knowledge on the cellular and molecular mechanisms underlying Hebbian and homeostatic forms of synaptic plasticity. The exact nature of cellular interactions and the associated signaling pathways that contribute to the modulation of synaptic strength in cerebral networks, as well as an assessment of whether these processes are ubiquitous or show region specificity in the healthy brain, remain a current topic of major interest. In addition, we welcome all articles that consider if specific alterations of synaptic adaptative processes are indicative of selective brain-related disorders that could help to initiate new preventive strategies.

Dr. Jean-Marie Billard
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cellular networks
  • synaptic strength
  • Hebbian plasticity
  • homeostatic plasticity
  • neuron–glia interactions
  • brain disorders
  • cognitive functions

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Related Special Issue

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

17 pages, 3558 KiB  
Article
Treadmill Exercise Facilitates Synaptic Plasticity in APP/PS1 Mice by Regulating Hippocampal AMPAR Activity
by Laikang Yu, Yan Li, Yuanyuan Lv, Boya Gu, Jiajia Cai, Qing-Song Liu and Li Zhao
Cells 2024, 13(19), 1608; https://doi.org/10.3390/cells13191608 - 25 Sep 2024
Cited by 1 | Viewed by 1145
Abstract
Accumulating evidence underscores exercise as a straightforward and cost-effective lifestyle intervention capable of mitigating the risk and slowing the emergence and progression of Alzheimer’s disease (AD). However, the intricate cellular and molecular mechanisms mediating these exercise-induced benefits in AD remain elusive. The present [...] Read more.
Accumulating evidence underscores exercise as a straightforward and cost-effective lifestyle intervention capable of mitigating the risk and slowing the emergence and progression of Alzheimer’s disease (AD). However, the intricate cellular and molecular mechanisms mediating these exercise-induced benefits in AD remain elusive. The present study delved into the impact of treadmill exercise on memory retrieval performance, hippocampal synaptic plasticity, synaptic morphology, and the expression and activity of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptors (AMPARs) in 6-month-old APP/PS1 mice. APP/PS1 mice (4-month-old males) were randomly assigned to either a treadmill exercise group or a sedentary group, with C57BL/6J mice (4-month-old males) as the control group (both exercise and sedentary). The exercise regimen spanned 8 weeks. Our findings revealed that 8-week treadmill exercise reversed memory retrieval impairment in step-down fear conditioning in 6-month-old APP/PS1 mice. Additionally, treadmill exercise enhanced basic synaptic strength, short-term potentiation (STP), and long-term potentiation (LTP) of the hippocampus in these mice. Moreover, treadmill exercise correlated with an augmentation in synapse numbers, refinement of synaptic structures, and heightened expression and activity of AMPARs. Our findings suggest that treadmill exercise improves behavioral performance and facilitates synaptic transmission by increasing structural synaptic plasticity and the activity of AMPARs in the hippocampus of 6-month-old APP/PS1 mice, which is involved in pre- and postsynaptic processes. Full article
Show Figures

Figure 1

Review

Jump to: Research

38 pages, 4043 KiB  
Review
Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus
by Pavel P. Tregub, Yulia K. Komleva, Maria V. Kukla, Anton S. Averchuk, Anna S. Vetchinova, Natalia A. Rozanova, Sergey N. Illarioshkin and Alla B. Salmina
Cells 2025, 14(2), 143; https://doi.org/10.3390/cells14020143 - 19 Jan 2025
Viewed by 686
Abstract
Brain plasticity is at the basis of many cognitive functions, including learning and memory. It includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the formation and elimination of synapses. The plasticity of synaptic transmission involves the expression of immediate early genes [...] Read more.
Brain plasticity is at the basis of many cognitive functions, including learning and memory. It includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the formation and elimination of synapses. The plasticity of synaptic transmission involves the expression of immediate early genes (IEGs) that regulate neuronal activity, thereby supporting learning and memory. In addition, IEGs are involved in the regulation of brain cells’ metabolism, proliferation, and survival, in the establishment of multicellular ensembles, and, presumably, in cell competition in the tissue. In this review, we analyze the current understanding of the role of IEGs (c-Fos, c-Myc, Arg3.1/Arc) in controlling brain plasticity in physiological and pathological conditions, including brain aging and neurodegeneration. This work might inspire new gene therapy strategies targeting IEGs to regulate synaptic plasticity, and potentially prevent or mitigate neurodegenerative diseases. Full article
Show Figures

Graphical abstract

Back to TopTop