Progress in the Field of Aldehyde Dehydrogenase (ALDH) Researches
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 6694
Special Issue Editors
Interests: NAD homeostasis; dehydrogenases; target validation; enzymology; structural biology; protein-protein interaction; drug discovery; ALDHs
Special Issue Information
Dear Colleagues,
Research on the role of aldehyde dehydrogenases (ALDHs) is constantly evolving and continues to provide our scientific community with numerous interesting results regrading both their physiological and pathological roles. ALDHs comprise a superfamily of NAD(P+)-dependent isoforms characterized by distinctive subcellular localization and playing a crucial role in a wide spectrum of biological functions. Besides catalyzing the irreversible oxidation of both aliphatic and aromatic aldehydes, thus exerting a detoxifying role, ALDHs are in charge of the synthesis of retinoic acid, a key mediator for cell proliferation and differentiation, and affect vitality, self-renewing, and expansion of embryonal tissues and cells, showing a stem-like phenotype. The clinical importance of the ALDHs is evidenced from human phenotypes directly linked to mutations in ALDH genes, leading to the absence, deficiency or inactivation of ALDH proteins. In addition, multiple disease states are associated with ALDH dysfunction, including many cancers, metabolic diseases and neurological abnormalities. They also have structural roles in the eye, as crystallins, and serve as binding molecules to endobiotics and xenobiotics, including androgens, cholesterol, and thyroid hormone. Alterations in ALDHs expression and functioning are at the molecular basis of several pathological conditions. Actually, experimental evidence at the genetic, transcriptomic and protein levels suggests the involvement of these enzymes in carcinogenesis and neurodegeneration, including Parkinson´s and Alzheimer´s diseases. The significant physio-pathological role of the ALDHs superfamily, stimulating lively and evolving investigational studies, justifies this Special Issue, which is thought of as a forum to bring together a collection of original research articles, reviews, and communications, covering any topics related to this wide and multi-faceted class of enzymes.
Prof. Dr. Silvia Garavaglia
Prof. Dr. Concettina La Motta
Guest Editors
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Keywords
- aldehyde dehydrogenase
- aldehyde dehydrogenase superfamily
- aldehydes
- detoxification
- retinoic acid
- stem cells
- cancer stem cells
- carcinogenesis
- neurodegeneration
- all-trans-retinaldehyde
- ALDHs target validation
- alcohol metabolism
- aldehyde metabolism
- aldehyde detoxification function
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