Ovary and Brain—Series II

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Reproductive Cells and Development".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 816

Special Issue Editor


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Guest Editor
Department of Biomedical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA
Interests: cell death; ovarian cancer; cancer stem cells; cell programmed necrosis (necroptosis); chemoresistance
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Special Issue Information

Dear Colleagues,

The brain and the ovaries are in a state of continuous communication. This ovary–brain connection is essential for regulating physiological functions. Recent advancements in genetic and cell biology have illuminated shared pathways supporting this connection within different development phases   of female reproductive health.

Following the success of our inaugural edition, titled "Ovary and Brain," which featured seven insightful articles, we are thrilled to announce the second edition of our Special Issue. This edition will delve deeper into the fascinating intersection of reciprocity between ovary and brain, aiming to enhance our understanding of the common pathways and mechanisms that underlie the development of various pathological conditions.

Topics of Interest:

We enthusiastically welcome contributions on various physiological facets of the interplay between the ovary and the brain during various phases of life, encompassing but not limited to puberty, reproduction, menopause, and aging in health and disease. We also welcome contributions that focus on the reciprocity of the ovary–brain interactions in pathological conditions such as cancer, rare genetic disorders, and neurodegenerative disorders. Finally, we are also interested in contributions that explore ovarian function in addiction and drug abuse.

  • shared signaling pathways;
  • metabolism;
  • genetic and epigenetic modification;
  • organelle and their function;
  • stem cells;
  • therapeutic strategies targeting common pathways;
  • microtubule dynamics;
  • mitochondrial function.

We extend an invitation to researchers and experts in the fields of reproductive sciences and brain studies to share their valuable insights in this special edition. Together, let us propel our understanding of these intricate fields and chart new avenues for therapeutic interventions.

We cordially invite you to contribute original articles, reviews, and communications. Your participation will undoubtedly enrich the discourse of this Special Issue. We are looking forward to your contributions to this Special Issue.

Dr. Ilana I. Chefetz
Guest Editor

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Keywords

  • ovary 
  • ovary-brain communication 
  • cancer 
  • neurodegenerative diseases 
  • mitochondrial dysfunction 
  • cancer therapy 
  • neurodegeneration mechanisms 
  • therapeutic interventions 
  • signaling pathways 
  • molecular targets 
  • precision medicine 
  • biomarkers 
  • cellular dynamics 
  • translational research 
  • addiction 
  • reproductive health

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Related Special Issue

Published Papers (1 paper)

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Review

21 pages, 2483 KiB  
Review
Similarities in Mechanisms of Ovarian Cancer Metastasis and Brain Glioblastoma Multiforme Invasion Suggest Common Therapeutic Targets
by Gia A. Jackson and David Cory Adamson
Cells 2025, 14(3), 171; https://doi.org/10.3390/cells14030171 - 23 Jan 2025
Viewed by 463
Abstract
Epithelial-to-mesenchymal transition (EMT) is a critical process in malignant ovarian cancer metastasis. EMT involves the conversion of epithelial cells to mesenchymal cells, conferring enhanced migratory and invasive capabilities. Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor and exhibits an aggressive [...] Read more.
Epithelial-to-mesenchymal transition (EMT) is a critical process in malignant ovarian cancer metastasis. EMT involves the conversion of epithelial cells to mesenchymal cells, conferring enhanced migratory and invasive capabilities. Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor and exhibits an aggressive invasive phenotype that mimics some steps of EMT but does not undergo true metastasis, i.e., the invasion of other organ systems. This study conducts a comparative genomic analysis of EMT in ovarian cancer and invasion in GBM—two malignancies characterized by poor prognosis and limited therapies. Investigating the molecular biology in ovarian cancer and GBM demonstrates shared mechanisms of tumor progression, such as similar genetic and molecular pathways influencing cell plasticity, invasion, and resistance to therapy. The comparative analysis reveals commonalities and differences in the regulatory networks and gene expression profiles associated with EMT and invasion in these cancers. Key findings include the identification of core EMT regulators, such as TWIST1, SNAIL, and ZEB1, which are upregulated in both ovarian cancer and GBM, promoting mesenchymal phenotypes and metastasis. Additionally, the analysis uncovers EMT-related pathways, such as the PI3K/AKT and TGF-β signaling, which are critical in both cancers but exhibit distinct regulatory dynamics. Understanding the intricacies of EMT in ovarian cancer and invasion in GBM provides valuable insights into their aggressive behavior and identifies potential common therapeutic targets. The findings stress the importance of targeting EMT/invasion transitions to develop effective treatments to halt progression and improve patient outcomes in these malignancies. Full article
(This article belongs to the Special Issue Ovary and Brain—Series II)
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